Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors inFundulus heteroclitus

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Role of Quinones in Toxicology

2000 • 1,601 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

2000 • 978 citations

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity

1996 • 820 citations

Enhancing ecotoxicological modeling and assessment. Body Residues and Modes Of Toxic Action

1993 • 538 citations

PAHs: An Ecotoxicological Perspective

2003 • 482 citations

Urban Sprawl Leaves Its PAH Signature

2000 • 463 citations

Sensitivity of fish embryos to weathered crude oil: Part I. Low‐level exposure during incubation causes malformations, genetic damage, and mortality in larval pacific herring (Clupea pallasi)

1999 • 445 citations

Inhibitors of Cytochrome P-450s and Their Mechanism of Action

1981 • 396 citations

Technical basis for narcotic chemicals and polycyclic aromatic hydrocarbon criteria. I. Water and tissue

2000 • 380 citations

The aryl hydrocarbon receptor: A comparative perspective

1998 • 368 citations

Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation

2004 • 312 citations

Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss)

1991 • 295 citations

Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family

1997 • 276 citations

Evaluation of Fish Early Life-Stage Toxicity Models of Chronic Embryonic Exposures to Complex Polycyclic Aromatic Hydrocarbon Mixtures

2003 • 250 citations

Oxidative Inactivation of Cytochrome P-450 1A (CYP1A) Stimulated by 3,3′,4,4′-Tetrachlorobiphenyl: Production of Reactive Oxygen by Vertebrate CYP1As

1999 • 245 citations

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1990 • 240 citations

Comparative toxicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin to seven freshwater fish species during early life‐stage development

1998 • 202 citations

Toxicity of retene to early life stages of two freshwater fish species

1999 • 196 citations

Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1990 • 192 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis

2002 • 184 citations

Interaction of Methylenedioxyphenyl (1,3-Benzodioxole) Compounds with Enzymes and Their Effects on Mammals

1975 • 183 citations

Binding of polycyclic aromatic hydrocarbons (PAHs) to teleost aryl hydrocarbon receptors (AHRs)

2002 • 180 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish

2003 • 173 citations

The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor

2002 • 171 citations

Cytochrome P4501A (CYP1A) in Killifish (Fundulus heteroclitus): Heritability of Altered Expression and Relationship to Survival in Contaminated Sediments

2002 • 167 citations

Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.

2000 • 164 citations

Correlation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induction of Cytochrome P4501A in Vascular Endothelium with Toxicity in Early Life Stages of Lake Trout

1997 • 163 citations

Identification and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the TeleostFundulus heteroclitus

1999 • 161 citations

Route-Specific Cellular Expression of Cytochrome P4501A (CYP1A) in Fish (Fundulus heteroclitus) Following Exposure to Aqueous and Dietary Benzo[a]pyrene

1997 • 158 citations

Embryotoxicity of 2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD): The Embryonic Vasculature Is a Physiological Target for TCDD-Induced DNA Damage and Apoptotic Cell Death in Medaka ()

1996 • 157 citations

Induction and suppression of cytochrome P450 1A by 3,3′,4,4′,5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops)

2001 • 132 citations

Cytochrome P4501A induction potencies of polycyclic aromatic hydrocarbons in a fish hepatoma cell line: Demonstration of additive interactions

2000 • 130 citations

Oxidative Metabolism of Polycyclic Aromatic Hydrocarbons to Ultimate Carcinogens

1982 • 129 citations

Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Theembryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes)

1996 • 125 citations

Altering cytochrome P4501A activity affects polycyclic aromatic hydrocarbon metabolism and toxicity in rainbow trout (Oncorhynchus mykiss)

2002 • 123 citations

Evaluation of Chemicals as Inhibitors of Trout Cytochrome P450s

1998 • 114 citations

Cyp1a1(−/−) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria

2004 • 114 citations

In Vivo and in Vitro Inhibition of CYP1A-Dependent Activity in Fundulus heteroclitus by the Polynuclear Aromatic Hydrocarbon Fluoranthene

2001 • 112 citations

Benzo[a]pyrene-Induced Toxicity: Paradoxical Protection in Cyp1a1(−/−) Knockout Mice Having Increased Hepatic BaP–DNA Adduct Levels

2001 • 112 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of rainbow trout (Salmo Gairdneri, Richardson)

1981 • 110 citations

Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners

1999 • 96 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos

2001 • 96 citations

Protection of the Cyp1a2(−/−) Null Mouse against Uroporphyria and Hepatic Injury Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

2001 • 93 citations

Mechanism of Action of α-Naphthoflavone as an Ah Receptor Antagonist in MCF-7 Human Breast Cancer Cells

1993 • 92 citations

The mechanism of action of α-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1990 • 86 citations

Nondestructive indicator of ethoxyresorufin‐O‐deethylase activity in embryonic fish

1998 • 80 citations

Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7, 12-dimethylbenz[a] anthracene in rainbow trout embryos

1993 • 78 citations

Inhibition of CYP1A1-Dependent Activity by the Polynuclear Aromatic Hydrocarbon (PAH) Fluoranthene

1998 • 76 citations

Identification of primary aromatic amines in mutagenically active subfractions from coal liquefaction materials

1980 • 75 citations

Technical basis for polar and nonpolar narcotic chemicals and polycyclic aromatic hydrocarbon criteria. III. A polyparameter model for target lipid partitioning

2009 • 73 citations

Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists

1996 • 73 citations

Induction of hepatic cytochrome p-450 in fish and the indication of environmental induction in scup (Stenotomus chrysops)

1981 • 72 citations

Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists

1993 • 71 citations

Dietary accumulation and biochemical responses of juvenile rainbow trout (Oncorhynchus mykiss) to 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126)

2002 • 70 citations

Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

1992 • 69 citations

Biological half-lives of eight polycyclic aromatic hydrocarbons (PAHs) in rainbow trout (Salmo gairdneri)

1986 • 67 citations

Relevance of different biological assays in assessing initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency

1996 • 66 citations

Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro.

1997 • 64 citations

Genetic structure of Fundulus heteroclitus from PAH-contaminated and neighboring sites in the Elizabeth and York Rivers

2002 • 63 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproduction and oogenesis in zebrafish (Brachydanio rerio)

1992 • 62 citations

Correlation of Cardiotoxicity Mediated by Halogenated Aromatic Hydrocarbons to Aryl Hydrocarbon Receptor Activation

2001 • 61 citations

Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.

1993 • 58 citations

Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes

2003 • 56 citations

Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors

2004 • 54 citations

Relative concentrations of polyaromatic primary amines and azaarenes in mutagenically active nitrogen fractions from a coal liquid

1981 • 31 citations

Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or β-naphthoflavone

1995 • 29 citations

Aminoanthracene Is a Mechanism-Based Inactivator of CYP1A in Channel Catfish Hepatic Tissue

1995 • 27 citations

Developmental Toxicity and EROD Induction in the Japanese Medaka ( Oryzias latipes ) Treated with Dioxin Congeners

1999 • 27 citations

A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus

2005 • 21 citations

Interaction of isosafrole, β-naphthoflavone and other CYP1A inducers in liver of rainbow trout (Oncorhynchus mykiss) and eelpout (Zoarces viviparus)

1998 • 21 citations

In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by α-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct

1995 • 19 citations

Hepatic P4501A activity, plasma sex steroids, and gonadal steroidogenesis in vitro in yellow perch exposed to 3, 3′, 4, 4′, 5‐pentachlorobiphenyl

2000 • 12 citations

HEPATIC P4501A ACTIVITY, PLASMA SEX STEROIDS, AND GONADAL STEROIDOGENESIS IN VITRO IN YELLOW PERCH EXPOSED TO 3,3′,4,4′,5-PENTACHLOROBIPHENYL

2000 • 5 citations