Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

1998 • 553 citations

A new nomenclature for the aldo-keto reductase superfamily

1997 • 350 citations

The mechanism of dioxin toxicity: relationship to risk assessment.

1994 • 327 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Nucleic Acids and Metals

1959 • 270 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription

1996 • 245 citations

Molecular biology of the aromatic hydrocarbon (dioxin) receptor

1994 • 234 citations

Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbon trans-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase

1996 • 234 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.

1999 • 192 citations

Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene

1997 • 187 citations

The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1996 • 164 citations

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

1984 • 154 citations

Response of Human CYP1-Luciferase Plasmids to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Polycyclic Aromatic Hydrocarbons

1993 • 147 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

DNA Strand Scission by Polycyclic Aromatic Hydrocarbon o-Quinones: Role of Reactive Oxygen Species, Cu(II)/Cu(I) Redox Cycling, and o-Semiquinone Anion Radicals^,

1997 • 137 citations

Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons.

1986 • 136 citations

Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione^,

1998 • 134 citations

Synthesis and Characterization of Polycyclic Aromatic Hydrocarbon o-Quinone Depurinating N7-Guanine Adducts

1999 • 132 citations

Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

1986 • 131 citations

Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.

1988 • 122 citations

Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts

1993 • 115 citations

Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon o-quinones produced by dihydrodiol dehydrogenase

1996 • 113 citations

Cell-specific regulation of human CYP1A1 and CYP1B1 genes.

1997 • 110 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1.

1994 • 97 citations

Prolonged depletion of AH receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1998 • 93 citations

Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing.

1988 • 76 citations

Interaction of Copper(I) with Nucleic Acids

1990 • 75 citations

Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase^,

1996 • 73 citations

A critical evaluation of the use of mutagenesis, carcinogenesis, and tumor promotion data in a cancer risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 63 citations

DNA polymerase action on benzo[a]pyrene—DNA adducts

1992 • 57 citations

Synthesis of the non-K-region o-quinones and dihydrodiols of polycyclic aromatic hydrocarbons from the corresponding phenols

1980 • 55 citations

NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization.

1988 • 52 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: Gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion

1996 • 40 citations

Spectroscopic Identification of ortho-Quinones as the Products of Polycyclic Aromatic trans-Dihydrodiol Oxidation Catalyzed by Dihydrodiol Dehydrogenase

1987 • 28 citations

Metabolism of Epoxides

1982 • 18 citations

X-ray Analyses of Polycyclic Hydrocarbon Metabolite Structures

1985 • 8 citations