The Nature and Identity of the Internal Excitational Transmitter of Vertebrate Phototransduction

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Responses of retinal rods to single photons.

1979 • 971 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis.

1984 • 689 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

Dark Current and Photocurrent in Retinal Rods

1970 • 555 citations

Electrical responses of single cones in the retina of the turtle

1970 • 542 citations

Changes in time scale and sensitivity in the ommatidia of Limulus

1964 • 523 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

The membrane current of single rod outer segments

1979 • 486 citations

The electrical response of turtle cones to flashes and steps of light

1974 • 471 citations

Two components of electrical dark noise in toad retinal rod outer segments.

1980 • 462 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Light‐induced binding of 48‐kDa protein to photoreceptor membranes is highly enhanced by phosphorylation of rhodopsin

1984 • 358 citations

Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores

1986 • 336 citations

Kinetics of the Photocurrent of Retinal Rods

1972 • 334 citations

Spatial spread of activation and background desensitization in toad rod outer segments

1981 • 292 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

Light-suppressible, cyclic GMP-sensitive conductance in the plasma membrane of a truncated rod outer segment

1985 • 289 citations

Calcium and cAMP as synarchic messengers

1982 • 284 citations

The ionic selectivity and calcium dependence of the light‐sensitive pathway in toad rods.

1985 • 269 citations

Electrical activity of vertebrate photoreceptors

1970 • 260 citations

Cyclic GMP-sensitive conductance in outer segment membrane of catfish cones

1985 • 260 citations

A voltage‐clamp study of the light response in solitary rods of the tiger salamander.

1979 • 241 citations

Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

1985 • 230 citations

Ionic mechanism for the photoreceptor potential of the retina of Bufo marinus

1974 • 215 citations

A light-activated GTPase in vertebrate photoreceptors: Regulation of light-activated cyclic GMP phosphodiesterase

1977 • 208 citations

A role for Ca2+ in excitation of retinal rods and cones

1974 • 205 citations

Light-induced calcium release by intact retinal rods.

1980 • 200 citations

Light-induced calcium fluxes from outer segment layer of vertebrate retinas

1980 • 190 citations

Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.

1979 • 186 citations

Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments.

1979 • 183 citations

Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation.

1983 • 171 citations

Effect of ions on the light-sensitive current in retinal rods

1981 • 169 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Electrical properties of the light‐sensitive conductance of rods of the salamander Ambystoma tigrinum.

1986 • 161 citations

Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rods.

1986 • 160 citations

Calcium modulation of cyclic GMP synthesis in rat visual cells

1982 • 153 citations

Adenyl Cyclase as a Link between Photon Capture and Changes in Membrane Permeability of Frog Photoreceptors

1971 • 152 citations

Patch‐clamp recordings of the light‐sensitive dark noise in retinal rods from the lizard and frog.

1985 • 147 citations

Mechanism of ATP quench of phosphodiesterase activation in rod disc membranes.

1983 • 144 citations

Elemental distribution in Rana pipiens retinal rods: quantitative electron probe analysis.

1985 • 143 citations

Control of the cyclic GMP phosphodiesterase of frog photoreceptor membranes.

1980 • 142 citations

Guanylate cyclase of isolated bovine retinal rod axonemes

1979 • 137 citations

Cyclic GMP injected into retinal rod outer segments increases latency and amplitude of response to illumination.

1978 • 137 citations

Calcium and cyclic nucleotide regulation in incubated mouse retinas.

1978 • 131 citations

Effects on the photoresponse of calcium buffers and cyclic GMP incorporated into the cytoplasm of retinal rods

1985 • 125 citations

Light adaption of the cyclic GMP phosphodiesterase of frog photoreceptor membranes mediated by ATP and calcium ions.

1981 • 122 citations

Location and function of voltage‐sensitive conductances in retinal rods of the salamander, Ambystoma tigrinum.

1984 • 121 citations

Cyclic Nucleotide Phosphodiesterase: High Activity in a Mammalian Photoreceptor

1972 • 115 citations

The properties of single cones isolated from the tiger salamander retina

1982 • 110 citations

GTP hydrolysis in intact rod outer segments and the transmitter cycle in visual excitation

1979 • 108 citations

Fast Ionic Flux Activated by Cyclic GMP in the Membrane of Cattle Rod Outer Segments

1983 • 107 citations

Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP

1985 • 102 citations

Light-induced decreases in cGMP concentration precede changes in membrane permeability in frog rod photoreceptors.

1984 • 96 citations

Light-initiated changes of cyclic guanosine monophosphate levels in the frog retina measured with quick-freezing techniques.

1979 • 95 citations

Kinetic studies suggest that light-activated cyclic GMP phosphodiesterase is a complex with G-protein subunits

1986 • 93 citations

Cyclic GMP and the permeability of the disks of the frog photoreceptors.

1979 • 92 citations

Effects of injections of calcium and EGTA into the outer segments of retinal rods of Bufo marinus

1977 • 90 citations

Gain, speed and sensitivity of GTP binding vs PDE activation in visual excitation

1982 • 86 citations

Light adaptation in toad rods: requirement for an internal messenger which is not calcium.

1979 • 85 citations

Cyclic GMP releases calcium from disc membranes of vertebrate photoreceptors.

1981 • 82 citations

Light-dependent calcium release from photoreceptors measured by laser micro-mass analysis

1984 • 82 citations

Control of the generator current in solitary rods of the Ambystoma tigrinum retina.

1984 • 79 citations

Dependence of the single photon response on longitudinal position of absorption in toad rod outer segments.

1983 • 73 citations

Light‐Induced Interactions between Rhodopsin and the GTP‐Binding Protein

1982 • 70 citations

The effect of rhodopsin phosphorylation on the light‐dependent activation of phosphodiesterase from bovine rod outer segments

1985 • 69 citations

Comparison of the light-sensitive and cyclic GMP-sensitive conductances of the rod photoreceptor: noise characteristics

1986 • 64 citations

Spread of the light response along the rod outer segment: An estimate from patch-clamp recordings

1986 • 61 citations

Phosphorylation at sites near rhodopsin'scarboxyl-terminus regulates light initiated CGMP hydrolysis

1984 • 60 citations

Gigaseal patch clamp recordings from outer segments of intact retinal rods

1982 • 58 citations

Physiological evidence that light-mediated decrease in cyclic GMP is an intermediary process in retinal rod transduction.

1982 • 58 citations

Protons suppress the dark current of frog retinal rods.

1984 • 53 citations

Detection of α-Transducin in Retinal Rods But Not Cones

1986 • 48 citations

Calcium content and calcium exchange in dark‐adapted toad rods.

1985 • 47 citations

BIOCHEMICAL STEPS IN VISUAL TRANSDUCTION: ROLES FOR NUCLEOTIDES AND CALCIUM IONS*

1980 • 44 citations

Plasma membrane calcium fluxes in intact rods are inconsistent with the "calcium hypothesis".

1986 • 41 citations

The Structural Organization of Mammalian Retinal Disc Membrane

1980 • 37 citations

Light-induced changes of cyclic GMP content in frog retinal rod outer segments measured with rapid freezing and microdissection

1981 • 37 citations

Light-induced changes in membrane current in cone outer segments of tiger salamander and turtle

1980 • 36 citations

Injection of GTP-binding protein or cyclic GMP phosphodiesterase hyperpolarizes retinal rods

1983 • 34 citations

Sensitive light scattering probe of enzymatic processes in retinal rod photoreceptor membranes

1984 • 32 citations

Activation of rod outer segment phosphodiesterase by enzymatically altered rhodopsin: A regulatory role for the carboxyl terminus of rhodopsin

1984 • 29 citations

Effects of calcium and guanosine‐3',5'‐cyclic‐monophosphoric acid on receptor potentials of toad rods.

1983 • 25 citations

Incorporation of a retinal rod cGMP-dependent conductance into planar bilayers.

1987 • 20 citations

Effect of cGMP and cations on the permeability of cattle retinal disks

1985 • 20 citations

Intracellular injection of cyclic-GMP increases sodium conductance in gecko photoreceptors.

1983 • 19 citations

Modulation of membrane conductance in rods of Bufo marinus by intracellular calcium ion.

1983 • 16 citations

Chapter 20 Effects of Cyclic Nucleotides and Calcium Ions on Bufo Rods

1981 • 13 citations

Calcium-dependent activation and deactivation of rod outer segment phosphodiesterase is calmodulin-independent

1983 • 13 citations

Rod light response augmented by active phosphodiesterase.

1984 • 9 citations

Properties of Cytoplasmic Transmitters of Excitation in Vertebrate Rods and Evaluation of Candidate Intermediary Transmitters

1986 • 2 citations