Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Regulators of G-Protein signalling as new central nervous system drug targets

2002 • 395 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System

2001 • 314 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways

1999 • 278 citations

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

2001 • 261 citations

RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

2001 • 223 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gα _i subunits

2000 • 164 citations

The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor

1999 • 163 citations

GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.

1985 • 143 citations

Stabilization of the GDP-bound Conformation of Giα by a Peptide Derived from the G-protein Regulatory Motif of AGS3

2000 • 135 citations

Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein

2001 • 111 citations

AGS3 Inhibits GDP Dissociation from Gα Subunits of the Gi Family and Rhodopsin-dependent Activation of Transducin

2000 • 105 citations

Structural basis of activity and subunit recognition in G protein heterotrimers

1998 • 99 citations

Crystal Structures of the G Protein G_iα1 Complexed with GDP and Mg²⁺: A Crystallographic Titration Experiment

1998 • 94 citations

Inhibition of GDP/GTP Exchange on Gα Subunits by Proteins Containing G-Protein Regulatory Motifs

2001 • 85 citations

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras

1993 • 78 citations

The Conserved Arginine in Rho-GTPase-Activating Protein Is Essential for Efficient Catalysis but Not for Complex Formation with Rho·GDP and Aluminum Fluoride

1998 • 74 citations

Interdomain Interactions Regulate GDP Release from Heterotrimeric G Proteins

1999 • 44 citations