Endoglin overexpression modulates cellular morphology, migration, and adhesion of mouse fibroblasts

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Hereditary Hemorrhagic Telangiectasia

1995 • 1,052 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

1997 • 715 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Fibronectins

1990 • 523 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.

1997 • 288 citations

Ultrastructure and Three-Dimensional Organization of the Telangiectases of Hereditary Hemorrhagic Telangiectasia

1990 • 271 citations

A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1.

1993 • 270 citations

Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.

1988 • 256 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

Role of Endoglin in Cellular Responses to Transforming Growth Factor-β

1998 • 223 citations

Regulated expression on human macrophages of endoglin, an Arg‐Gly‐Asp‐containing surface antigen

1992 • 222 citations

Identification and expression of two forms of the human transforming growth factor‐β‐binding protein endoglin with distinct cytoplasmic regions

1993 • 212 citations

Endoglin Regulates Trophoblast Differentiation along the Invasive Pathway in Human Placental Villous Explants*

1997 • 199 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts

1992 • 186 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Integrins and vascular extracellular matrix assembly.

1997 • 135 citations

Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

1994 • 133 citations

Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

1997 • 123 citations

Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration

1992 • 120 citations

Vitronectin Concentrates Proteolytic Activity on the Cell Surface and Extracellular Matrix by Trapping Soluble Urokinase Receptor-Urokinase Complexes

1998 • 114 citations

Binding of urokinase to plasminogen activator inhibitor type-1 mediates cell adhesion and spreading

1997 • 107 citations

Biosynthesis and acquisition of biological activity of the fibronectin receptor.

1987 • 104 citations

Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow.

1995 • 102 citations

Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events.

1991 • 102 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Assignment of the human endoglin gene (END) to 9q34→qter

1993 • 95 citations

Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia with Aminocaproic Acid

1994 • 93 citations

Hereditary haemorrhagic telangiectasia with extensive liver involvement is not caused by either HHT1 or HHT2.

1996 • 88 citations

Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-β ligand

1994 • 88 citations

Expression of Endoglin mRNA and Protein in Human Vascular Smooth Muscle Cells

1998 • 86 citations

TGF-β and the endothelium during immune injury

1997 • 85 citations

Genetic abnormalities in hereditary hemorrhagic telangiectasia

1998 • 83 citations

Specific induction of secreted proteins by transforming growth factor-beta and 12-O-tetradecanoylphorbol-13-acetate. Relationship with an inhibitor of plasminogen activator.

1987 • 72 citations

Endoglin: a 180-kD endothelial cell and macrophage restricted differentiation molecule

1992 • 71 citations

Phosphorylation of the human-transforming-growth-factor-β-binding protein endoglin

1994 • 71 citations

Changes in cell spreading and cytoskeletal organization are induced by adhesion to a fibronectin-fibrin matrix

1996 • 67 citations

Changes in cell spreading and cytoskeletal organization are induced by adhesion to a fibronectin-fibrin matrix

1996 • 65 citations

Endoglin is a component of the transforming growth factor (TGF)-beta receptor complex of human pre-B leukemic cells.

1996 • 63 citations

Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments

1997 • 63 citations

Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation

1998 • 62 citations

Molecular Defects in Rare Bleeding Disorders: Hereditary Haemorrhagic Telangiectasia

1997 • 61 citations

Molecular Crosstalk Between Adhesion Receptors and Proteolytic Cascades in Vascular Remodelling

1997 • 60 citations

Macromolecular Composition of Stress Fiber–Plasma Membrane Attachment Sites in Endothelial Cells In Situ

1996 • 58 citations

Antibodies to different members of the β1 (CD29) integrins induce homotypic and heterotypic cellular aggregation

1991 • 53 citations

Characterization of TGF‐β1‐binding proteins in human bone marrow stromal cells

1996 • 51 citations

Fibrinolytic Activity in Lesions of Hereditary Hemorrhagic Telangiectasia

1973 • 48 citations

Recurrence of neonatal haemochromatosis in half sibs born of unaffected mothers.

1996 • 44 citations

Factors inducing codistribution of marginal actin fibers and fibronectin in rat aortic endothelial cells

1997 • 12 citations

Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A

1997 • 11 citations