Nuclear-encoded mitochondrial proteins and their role in cardioprotection

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Mitochondrial formation of reactive oxygen species

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Mitochondrial formation of reactive oxygen species

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SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

2003 • 2,040 citations

Importing Mitochondrial Proteins: Machineries and Mechanisms

2009 • 1,346 citations

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

2008 • 1,256 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

2004 • 1,045 citations

Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

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Gap junctions and the connexin protein family

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Function of Mitochondrial Stat3 in Cellular Respiration

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Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

2010 • 901 citations

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

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Characterization of the human heart mitochondrial proteome

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Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

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Opening of Mitochondrial K _ATP Channels Triggers the Preconditioned State by Generating Free Radicals

2000 • 666 citations

Targeting an antioxidant to mitochondria decreases cardiac ischemia‐reperfusion injury

2005 • 581 citations

Mitochondrial Energetics in the Heart in Obesity-Related Diabetes

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Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC

2001 • 540 citations

Connexin43 phosphorylation: structural changes and biological effects

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Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

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Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

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Protein kinase C: poised to signal

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Postconditioning and protection from reperfusion injury: where do we stand? * Position Paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

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Decrease in Mitochondrial Complex I Activity in Ischemic/Reperfused Rat Heart

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Rapid Turnover of Connexin43 in the Adult Rat Heart

1998 • 425 citations

Generation of superoxide in cardiomyocytes during ischemia before reperfusion

1999 • 418 citations

Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart

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Significant Levels of Oxidants are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

1997 • 391 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Phosphorylation of Glycogen Synthase Kinase-3β During Preconditioning Through a Phosphatidylinositol-3-Kinase–Dependent Pathway Is Cardioprotective

2002 • 367 citations

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

2010 • 365 citations

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

2008 • 358 citations

Role of Glycogen Synthase Kinase-3β in Cardioprotection

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The myocardial JAK/STAT pathway: From protection to failure

2008 • 332 citations

Loss of cardioprotection with ageing

2009 • 312 citations

Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion

2000 • 311 citations

Inhibition of GSK3β by Postconditioning Is Required to Prevent Opening of the Mitochondrial Permeability Transition Pore During Reperfusion

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Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria

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Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning

2005 • 296 citations

Mitochondrial morphology and cardiovascular disease

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Combined and Individual Mitochondrial HSP60 and HSP10 Expression in Cardiac Myocytes Protects Mitochondrial Function and Prevents Apoptotic Cell Deaths Induced by Simulated Ischemia-Reoxygenation

2001 • 271 citations

Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice

2007 • 269 citations

Ischemic preconditioning alters real-time measure of O₂ radicals in intact hearts with ischemia and reperfusion

2003 • 263 citations

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

2004 • 257 citations

Protein Kinase C- ξ is Responsible for the Protection of Preconditioning in Rabbit Cardiomyocytes

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Ischemic Postconditioning in Pigs

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Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury

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Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations

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Excitation-contraction coupling and mitochondrial energetics

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Impairment of Diazoxide-Induced Formation of Reactive Oxygen Species and Loss of Cardioprotection in Connexin 43 Deficient Mice

2005 • 239 citations

Translocation of Connexin 43 to the Inner Mitochondrial Membrane of Cardiomyocytes Through the Heat Shock Protein 90–Dependent TOM Pathway and Its Importance for Cardioprotection

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Pim-1 regulates cardiomyocyte survival downstream of Akt

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Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria

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Autophagy in health and disease. 5. Mitophagy as a way of life

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Postconditioning A new link in nature’s armor against myocardial ischemia–reperfusion injury

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Modulation of the mitochondrial permeability transition pore complex in GSK-3β-mediated myocardial protection

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Opening mitoK_ATPincreases superoxide generation from complex I of the electron transport chain

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Preconditioning: The Mitochondrial Connection

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Additive Protection of the Ischemic Heart Ex Vivo by Combined Treatment With δ-Protein Kinase C Inhibitor and ε-Protein Kinase C Activator

2003 • 202 citations

The direct physiological effects of mitoK_ATPopening on heart mitochondria

2005 • 195 citations

Glycogen Synthase Kinase 3 Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates Voltage-Dependent Anion Channel Phosphorylation

2008 • 184 citations

Multiple pathways for mitochondrial protein traffic

2009 • 182 citations

Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43

2006 • 170 citations

Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo

2003 • 166 citations

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66Shc and monoamine oxidase

2009 • 164 citations

Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria

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Mitochondria and cardioprotection

2007 • 164 citations

Reactive oxygen species function as second messenger during ischemic preconditioning of heart.

1999 • 162 citations

Mechanisms of protein translocation into mitochondria

1999 • 158 citations

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations

2008 • 155 citations

Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes

2010 • 154 citations

Inhibition of Mitochondrial Permeability Transition Pore Opening by Ischemic Preconditioning Is Probably Mediated by Reduction of Oxidative Stress Rather Than Mitochondrial Protein Phosphorylation

2008 • 153 citations

Opening of mitochondrial K_ATP channel occurs downstream of PKC-ε activation in the mechanism of preconditioning

2002 • 152 citations

The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

2009 • 147 citations

Sca-1 ⁺ Stem Cell Survival and Engraftment in the Infarcted Heart

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(De)constructing Mitochondria: What For?

2006 • 147 citations

Mitochondrial PKCε and Mitochondrial ATP-Sensitive K ⁺ Channel Copurify and Coreconstitute to Form a Functioning Signaling Module in Proteoliposomes

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Contractile activity-induced adaptations in the mitochondrial protein import system

1998 • 145 citations

Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts

2002 • 142 citations

Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake

2009 • 137 citations

Quantitative Protein Profiling in Heart Mitochondria from Diabetic Rats

2003 • 136 citations

Translocation of Protein Kinase C Isoforms to Subcellular Targets in Ischemic and Anesthetic Preconditioning

2003 • 130 citations

Oxidant Stress during Simulated Ischemia Primes Cardiomyocytes for Cell Death during Reperfusion

2007 • 130 citations

Proteomic Analysis of Pharmacological Preconditioning

2006 • 130 citations

Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction

2010 • 128 citations

A CaPful of mechanisms regulating the mitochondrial permeability transition

2009 • 127 citations

Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling

2006 • 126 citations

Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning

2004 • 125 citations

Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning

2008 • 123 citations

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

2007 • 122 citations

Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury

2010 • 122 citations

Glycogen Synthase Kinase-3 Inactivation Is Not Required for Ischemic Preconditioning or Postconditioning in the Mouse

2008 • 120 citations

Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3β

2006 • 119 citations

Endoplasmic Reticulum Stress in Diabetic Hearts Abolishes Erythropoietin-Induced Myocardial Protection by Impairment of Phospho–Glycogen Synthase Kinase-3β–Mediated Suppression of Mitochondrial Permeability Transition

2009 • 118 citations

Simultaneous Overexpression of Two Stress Proteins in Rat Cardiomyocytes and Myogenic Cells Confers Protection Against Ischemia-Induced Injury

1997 • 117 citations

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of ɛPKC and activation of aldehyde dehydrogenase 2

2008 • 108 citations

No loss of cardioprotection by postconditioning in connexin 43-deficient mice

2006 • 106 citations

Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors

2006 • 104 citations

Gene expression profiling of the aging mouse cardiac myocytes

2002 • 100 citations

Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria

2008 • 100 citations

Mitochondrial protein import and human health and disease

2006 • 100 citations

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

2008 • 98 citations

Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes

2010 • 96 citations

Hsp90 Functions in the Targeting and Outer Membrane Translocation Steps of Tom70-mediated Mitochondrial Import

2006 • 95 citations

Connexin 43 in ischemic pre- and postconditioning

2007 • 92 citations

The SR-mitochondria interaction: a new player in cardiac pathophysiology

2010 • 87 citations

Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression

2007 • 84 citations

Regulating RISK: a role for JAK-STAT signaling in postconditioning?

2008 • 83 citations

Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells

2010 • 81 citations

Overexpression of PHGPx and HSP60/10 protects against ischemia/reoxygenation injury

2003 • 77 citations

Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes

2012 • 72 citations

Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes

2010 • 71 citations

Postconditioning induces an anti-apoptotic effect and preserves mitochondrial integrity in isolated rat hearts

2009 • 69 citations

Protein kinase C-ε coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-coxidase activity and cardioprotection

2007 • 64 citations

Cardioprotection leads to novel changes in the mitochondrial proteome

2009 • 60 citations

Tom20-mediated mitochondrial protein import in muscle cells during differentiation

2000 • 56 citations

Mitochondria in Postconditioning

2010 • 54 citations

Influence of aging on protein import into cardiac mitochondria

1997 • 53 citations

The divergent roles of protein kinase C epsilon and delta in simulated ischaemia–reperfusion injury in human myocardium

2009 • 52 citations

Large-Scale Characterization and Analysis of the Murine Cardiac Proteome

2009 • 52 citations

Myocardial reperfusion injury management: erythropoietin compared with postconditioning

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Signal Anchor Sequence Insertion into the Outer Mitochondrial Membrane

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Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia–reperfusion injury in a preclinical pig model

2004 • 35 citations

Prevention of the ischemia-induced decrease in mitochondrial Tom20 content by ischemic preconditioning

2006 • 34 citations

Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP‐ase pathway

2004 • 32 citations

Autocrine Stimulation of Cardiac Na ⁺ -Ca ²⁺ Exchanger Currents by Endogenous Endothelin Released by Angiotensin II

2002 • 28 citations

Differential Role of Pim-1 Kinase in Anesthetic-induced and Ischemic Preconditioning against Myocardial Infarction

2009 • 27 citations

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2008 • 24 citations

The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta

2009 • 23 citations

Mitochondrial respiration and membrane potential after low-flow ischemia are not affected by ischemic preconditioning

2007 • 17 citations

Beneficial effects of carvedilol in patients with ischemic cardiomyopathy and a "narrow" ORS

2003 • 3 citations