Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2006 • 5,824 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Mitochondrial Abnormalities in Alzheimer's Disease

2001 • 1,319 citations

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

2006 • 1,058 citations

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

2006 • 1,035 citations

Mitochondria take center stage in aging and neurodegeneration

2005 • 934 citations

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

2008 • 875 citations

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

2008 • 783 citations

Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial Dysfunction

2006 • 759 citations

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2005 • 703 citations

A “mitochondrial cascade hypothesis” for sporadic Alzheimer's disease

2004 • 652 citations

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

2008 • 635 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

2003 • 547 citations

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

2004 • 537 citations

Mitochondrial Disorders in the Nervous System

2008 • 524 citations

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

2000 • 459 citations

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

2004 • 398 citations

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

2002 • 364 citations

Abnormalities of mitochondrial enzymes in Alzheimer disease

1998 • 335 citations

Copper-Dependent Inhibition of Human CytochromecOxidase by a Dimeric Conformer of Amyloid-β_1-42

2005 • 314 citations

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

2004 • 313 citations

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

2004 • 280 citations

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

2005 • 280 citations

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

2009 • 258 citations

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

2008 • 216 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

2004 • 194 citations

Mitochondrial Dysfunction in Aging and Alzheimer's Disease: Strategies to Protect Neurons

2007 • 181 citations

Mitochondrial structural and functional dynamics in Huntington's disease

2009 • 152 citations

Evaluation of Dimebon in cellular model of Huntington's disease

2008 • 114 citations

β-Amyloid Precursor Protein Is a Direct Cleavage Target of HtrA2 Serine Protease

2006 • 93 citations

Development of Mitochondria‐targeted Aromatic‐cationic Peptides for Neurodegenerative Diseases

2008 • 90 citations

Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models

2005 • 72 citations