Epicutaneous administration of hapten through patch application augments TH2 responses which can downregulate the elicitation of murine contact hypersensitivity

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

High Frequency of IL-4–Producing CD4+ Allergen-Specific T Lymphocytes in Atopic Dermatitis Lesional Skin

1991 • 397 citations

Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.

1990 • 315 citations

Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions.

1995 • 274 citations

Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.

1995 • 271 citations

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

1995 • 243 citations

Functions of CD8 T-cell subsets secreting different cytokine patterns

1997 • 210 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Th1 Lymphokine Production Profiles of Nickel-Specific CD4+ T-Lymphocyte Clones from Nickel Contact Allergic and Non-Allergic Individuals

1992 • 189 citations

Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis.

1985 • 186 citations

Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice.

1996 • 185 citations

Regulation of contact hypersensitivity by interleukin 10.

1994 • 168 citations

In Vivo Effects of Interleukin-10 on Contact Hypersensitivity and Delayed-Type Hypersensitivity Reactions

1994 • 158 citations

IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo.

1995 • 139 citations

Low‐level infection with Trichuris muris significantly affects the polarization of the CD4 response

1994 • 137 citations

Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype

1992 • 120 citations

Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis.

1997 • 112 citations

Anti-inflammatory action of IL-4. Negative regulation of contact sensitivity to trinitrochlorobenzene.

1992 • 80 citations

Characterization of epitopes recognized by hapten-specific CD4+ T cells.

1995 • 80 citations

TH2-Type Infiltrating T Cells in Nickel-Induced Contact Dermatitis

1995 • 77 citations

Cytokine Gene Expression during the Elicitation Phase of Contact Sensitivity: Regulation By Endogenous IL-4

1997 • 76 citations

Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides.

1992 • 74 citations

Interleukin-4 is a critical cytokine in contact sensitivity.

1995 • 71 citations

Interferon-γ Inducible Protein (IP-10) Expression Is Mediated by CD8+ T Cells and Is Regulated by CD4+ T Cells During the Elicitation of Contact Hypersensitivity

1996 • 58 citations

Diminished Contact Hypersensitivity Response in IL‐4 Deficient Mice at a Late Phase of the Elicitation Reaction

1997 • 58 citations

The Distribution of 2,4-Dinitrophenyl Groups in Guinea Pig Skin Following Surface Application of 2,4-Dinitrochlorobenzene: An Immunofluorescent Study

1971 • 27 citations

The association between lung innate immunity and differential airway antigen- specific immune responses

1996 • 20 citations