Historical aspects of glutathione and cancer chemotherapy

GLUTATHIONE

1983 • 5,487 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The Glutathione Status of Cells

1978 • 1,218 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

New antibiotics, bleomycin A and B.

1966 • 721 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Glutathione metabolism as a determinant of therapeutic efficacy: a review.

1984 • 505 citations

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

1979 • 492 citations

Overview of enzyme systems involved in bioreduction of drugs and in redox cycling

1986 • 392 citations

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.

1986 • 380 citations

Effect of chelating agents and metal ions on the degradation of DNA by bleomycin

1978 • 367 citations

On an Autoxidisable Constituent of the Cell

1921 • 343 citations

ON THE MECHANISM OF ACTION OF BLEOMYCIN : SCISSION OF DNA STRANDS IN VITRO AND IN VIVO

1969 • 328 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

1987 • 288 citations

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

1981 • 247 citations

Glutathione-dependent synthesis of deoxyribonucleotides. Purification and characterization of glutaredoxin from Escherichia coli.

1979 • 245 citations

Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.

1984 • 235 citations

Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.

1987 • 232 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

1988 • 220 citations

ON GLUTATHIONE: A REINVESTIGATION

1929 • 214 citations

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione

1987 • 209 citations

Reduction in glutathione content of L-PAM resistant L1210 cells confers drug sensitivity

1982 • 205 citations

Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

1990 • 199 citations

Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.

1985 • 195 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Metallothionein-mediated cisplatin resistance in human ovarian carcinoma cells

1987 • 175 citations

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines

1989 • 168 citations

Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein

1981 • 168 citations

Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.

1985 • 165 citations

Metabolism and action of anti-cancer drugs

1987 • 161 citations

Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.

1987 • 155 citations

Dechlorination of l-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content

1983 • 154 citations

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

1990 • 148 citations

Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin.

1980 • 145 citations

Synthesis of glutathione

1935 • 138 citations

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.

1988 • 138 citations

Activity and toxicity of bleomycin.

1967 • 130 citations

Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.

1981 • 125 citations

Biosynthesis and regulation of glutathione:Toxicological implications

1980 • 123 citations

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

1987 • 113 citations

In Vivo and in Vitro binding of platinum to metallothionein

1984 • 107 citations

Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase.

1979 • 106 citations

Adriamycin: amelioration of toxicity by alpha-tocopherol.

1976 • 105 citations

A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro

1986 • 104 citations

Glutathione S-transferases and drug resistance

1991 • 98 citations

ON GLUTATHIONE

1922 • 97 citations

An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines

1990 • 97 citations

Resistance ot cisplatin and analogues: mechanisms and potential clinical implications

1988 • 96 citations

THE TITRATION CURVE OF GLUTATHIONE

1929 • 94 citations

Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.

1987 • 94 citations

Cysteamine-induced Increase of Cellular Glutathione-level : A New Hypothesis of the Radioprotective Mechanism

1965 • 83 citations

Increased resistance to chlorambucil in cultured cells with a high concentration of cytoplasmic metallothionein.

1983 • 83 citations

Tumour sulphydryl levels and sensitivity to the nitrogen mustard merophan

1963 • 77 citations

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

1989 • 72 citations

Activation and inactivation of neocarzinostatin-induced cleavage of DNA

1978 • 71 citations

The roles of intracellular glutathione in antineoplastic chemotherapy

1986 • 69 citations

Enhanced potentiation of cisplatin cytotoxicity in human ovarian carcinoma cells by prolonged glutathione depletion

1988 • 68 citations

Mechanisms of Resistance to Platinum Drugs

1988 • 63 citations

The coordination chemistry of bleomycin: a review

1980 • 62 citations

Intracellular reduction of the cupric ion of bleomycin copper complex and transfer of the cuprous ion to a cellular protein.

1977 • 59 citations

Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.

1988 • 55 citations

Membrane transport, sulfhydryl levels and DNA cross-linking in Chinese hamster ovary cell mutants sensitive and resistant to melphalan

1983 • 54 citations

The role of glutathione in determining the response of normal and tumour cells to anticancer drugs

1987 • 54 citations

A STUDY OF GLUTATHIONE

1929 • 53 citations

Deoxyribonucleic acid sugar damage in the action of neocarzinostatin

1980 • 51 citations

Alteration of bleomycin cytotoxicity by glutathione depletion or elevation

1984 • 50 citations

The relation of glutathione to cell respiration with special reference to hepatic tissue

1931 • 47 citations

Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.

1985 • 45 citations

Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice

1985 • 44 citations

Differential sensitization of human ovarian carcinoma and mouse L1210 cells to cisplatin and melphalan by glutathione depletion.

1986 • 44 citations

Oxygen radical detoxification enzymes in doxorubicin-sensitive and -resistant P388 murine leukemia cells.

1984 • 42 citations

Glutathione depletion greatly reduces neocarzinostatin cytotoxicity in Chinese hamster V79 cells.

1985 • 38 citations

Reduction of toxicity of nitrogen mustards by cysteine

1951 • 37 citations

Effect of sulfhydryl-containing compounds on the antitumor effects of adriamycin

1980 • 36 citations

Mechanism of natural and acquired resistance to methyl-bis-(beta-chlorethyl)-amine N-oxide in ascites tumors.

1961 • 29 citations

Interactions among iron(II) bleomycin, Lewis bases, and DNA.

1981 • 28 citations

Glutathione as a determinant of cellular response to doxorubicin.

1988 • 24 citations

Characterization of cellular lipids in doxorubicin-sensitive and -resistant P388 mouse leukemia cells

1986 • 22 citations

Intracellular glutathione as a determinant of responsiveness to antitumor drugs

1986 • 21 citations

Non-Protein Sulphydryl Group in the Original Strain and Sub-line of the Ascites Tumour resistant to Alkylating Reagents

1960 • 20 citations

Chemical, biochemical, and cellular properties of copper and iron bleomycins

1979 • 20 citations

Isolation by flow cytometry of a human ovarian tumor cell subpopulation exhibiting a high glutathione content phenotype and increased resistance to adriamycin

1989 • 19 citations

An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion

1988 • 17 citations

Influence of Cysteinamine, Methylamine and Cortisone on the Toxicity and Activity of Nitrogen Mustard

1953 • 13 citations

Activation by reduced glutathione of methotrexate transport into isolated rat liver cells

1982 • 12 citations

Metabolism of bleomycin and bleomycin like compounds

1987 • 10 citations

Effect of reduced glutathione (GSH) on pharmacokinetics and distribution of rifamycin SV in rats

1981 • 5 citations