Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1979 • 912 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors.

1983 • 534 citations

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

1982 • 507 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

[8] Chemical depletion of glutathione in vivo

1981 • 242 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Reduction in glutathione content of L-PAM resistant L1210 cells confers drug sensitivity

1982 • 205 citations

Radiosensitization of Hypoxic Tumor Cells by Depletion of Intracellular Glutathione

1982 • 176 citations

Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.

1978 • 154 citations

The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles

1982 • 120 citations

Role of glutathione in the hypoxic cell cytotoxicity of misonidazole.

1983 • 119 citations

Transport of melphalan by sensitive and resistant L1210 cells.

1980 • 109 citations

Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell

1979 • 100 citations

Reduction in cellular glutathione by buthionine sulfbximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard

1984 • 97 citations

Chemotherapy of ovarian cancer. New Approaches to Treatment

1972 • 92 citations

Amino acid-conferred protection against melphalan—Characterization of melphalan transport and correlation of uptake with cytotoxicity in cultured L1210 murine leukemia cells

1978 • 87 citations

Protection against the toxicity of alkylating agents by thiols: The mechanism of protection and its relevance to cancer chemotherapy

1966 • 86 citations

The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization

1982 • 82 citations

Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitro.

1979 • 79 citations

Mechanism of melphalan resistance developed in vitro in human melanoma cells.

1981 • 79 citations

Comparison of nitrogen‐mustard‐sensitive and ‐resistant yoshida sarcomas

1966 • 77 citations

Tumour sulphydryl levels and sensitivity to the nitrogen mustard merophan

1963 • 77 citations

In vitro systems for evaluation of combination chemotherapy

1980 • 77 citations

Cloning of human ovarian cancer cells in soft agar from malignant and peritoneal washings.

1980 • 73 citations

Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole.

1983 • 45 citations

Glutathione-conferred resistance to antineoplastics: Approaches toward its reduction

1984 • 37 citations

Selection and characterization of Chinese hamster ovary cell mutants resistant to melphalan (L-phenylalanine mustard).

1981 • 37 citations

Repair replication and unscheduled DNA synthesis in mammalian cell lines showing differential sensitivity to alkylating agents

1973 • 32 citations

Mechanism of natural and acquired resistance to methyl-bis-(beta-chlorethyl)-amine N-oxide in ascites tumors.

1961 • 29 citations

L-phenylalanine mustard (melphalan) uptake and cross-linking in the RPMI 6410 human lymphoblastoid cell line.

1980 • 29 citations

Glutathione: A protective mechanism against hepatotoxicity

1982 • 28 citations

Effect of thiols on toxicity and carcinostatic activity of cyclophosphamide.

1983 • 28 citations

MECHANISMS OF CLINICAL DRUG RESISTANCE TO ALKYLATING AGENTS

1975 • 16 citations

Mechanism of natural and acquired resistance to methyl-bis(2-chloroethyl)amine N-oxide in ascites tumors. I. Permeability of tumor cells to alkylating agents.

1962 • 11 citations