Differential Mechanisms of Plasminogen Activator Inhibitor-1 Gene Activation by Transforming Growth Factor-β and Tumor Necrosis Factor-α in Endothelial Cells

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

1999 • 772 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Smads as transcriptional co-modulators

2000 • 522 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

1999 • 441 citations

Role of Ras and Mapks in TGFβ signaling

2000 • 430 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Regulation of Type 1 Plasminogen Activator Inhibitor Gene Expression in Cultured Bovine Aortic Endothelial Cells

1989 • 248 citations

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

1999 • 217 citations

Sp1 Sites Mediate Activation of the Plasminogen Activator Inhibitor-1 Promoter by Glucose in Vascular Smooth Muscle Cells

1998 • 207 citations

Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells.

1991 • 158 citations

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

1999 • 155 citations

The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery Disease

1998 • 132 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family.

1999 • 107 citations

TGF-β-Activated Kinase 1 Stimulates NF-κB Activation by an NF-κB-Inducing Kinase-Independent Mechanism

1998 • 100 citations

Structure-function relationships in serpins: current concepts and controversies.

1998 • 86 citations

Transforming Growth Factor β Stimulates the Human Immunodeficiency Virus 1 Enhancer and Requires NF-κB Activity

1998 • 52 citations

Cyclic Nucleotide Regulation of Type-1 Plasminogen Activator-Inhibitor mRNA Stability in Rat Hepatoma Cells

1998 • 37 citations

Regulation of cancer invasion and vascularization by plasminogen activator inhibitor-1

1999 • 18 citations

The status of plasminogen activator inhibitor-1 as a therapeutic target

1997 • 6 citations