Mechanisms leading to progression of chronic renal injury: the interstitium

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

2002 • 1,792 citations

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

2002 • 1,491 citations

Blood Pressure Control, Proteinuria, and the Progression of Renal Disease

1995 • 1,325 citations

Pathophysiology of Progressive Nephropathies

1998 • 1,250 citations

Effect of lipid reduction on the progression of renal disease: A meta-analysis

2001 • 669 citations

Molecular basis of renal fibrosis

2000 • 627 citations

Structural-functional correlations in renal disease

1970 • 458 citations

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

2003 • 341 citations

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

2003 • 312 citations

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

2003 • 295 citations

The emerging role of transforming growth factor-beta in kidney diseases

1994 • 217 citations

Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.

2002 • 216 citations

Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

2003 • 209 citations

Plasminogen activator inhibitor-1 and the kidney

2002 • 186 citations

Activation of NF-κB in Tubular Epithelial Cells of Rats With Intense Proteinuria

2001 • 161 citations

In vivo bradykinin B2 receptor activation reduces renal fibrosis

2002 • 154 citations

Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Renal Injury Induced by Protein-Overload Proteinuria

2003 • 132 citations

In vivo bradykinin B2 receptor activation reduces renal fibrosis

2002 • 127 citations

C6 Mediates Chronic Progression of Tubulointerstitial Damage in Rats with Remnant Kidneys

2002 • 122 citations

Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

2002 • 102 citations

Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis

2003 • 101 citations

Early application of Met-RANTES ameliorates chronic allograft nephropathy

2002 • 98 citations

Proteinuria and Phenotypic Change of Proximal Tubular Cells

2003 • 93 citations

An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients11See Editorial by Fogo, p. 2274.

2002 • 85 citations

Role of cellular infiltrates in response to proteinuria

2001 • 84 citations

Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells

1998 • 71 citations

How renal cytokines and growth factors contribute to renal disease progression

2001 • 66 citations

Effect of lovastatin on small GTP binding proteins and on TGF-β1 and fibronectin expression

2000 • 58 citations

Role of angiotensin II in tubulointerstitial injury

2001 • 57 citations

The Renin-Angiotensin-Aldosterone System and Fibrinolysis in Progressive Renal Disease

2002 • 47 citations