Beneficial and ominous aspects of the pleiotropic action of erythropoietin

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Arzneimittelforschung

2012 • 3,595 citations

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

2000 • 1,409 citations

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial

2003 • 1,243 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial

2002 • 1,038 citations

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

2001 • 1,009 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

In vivo evidence that erythropoietin protects neurons from ischemic damage

1998 • 931 citations

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

2001 • 930 citations

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

2003 • 839 citations

Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. Procrit Study Group.

1998 • 769 citations

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

2000 • 720 citations

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

1999 • 716 citations

Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group.

1997 • 715 citations

Decreased Erythropoietin Response in Patients with the Anemia of Cancer

1990 • 680 citations

Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

1996 • 658 citations

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

2001 • 649 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 612 citations

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

2003 • 601 citations

Erythropoietin receptor mRNA expression in human endothelial cells.

1994 • 584 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells.

1990 • 574 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury

2003 • 552 citations

A novel protective effect of erythropoietin in the infarcted heart

2003 • 549 citations

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1998 • 543 citations

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies

2003 • 529 citations

Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

1999 • 526 citations

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

2002 • 522 citations

Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis

2003 • 512 citations

Erythropoietin regulates endothelial progenitor cells

2003 • 503 citations

Development and characterization of novel erythropoiesis stimulating protein (NESP)

2001 • 500 citations

Enhancement of therapeutic protein in vivo activities through glycoengineering

2003 • 488 citations

Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

1995 • 481 citations

Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury

2002 • 479 citations

Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]

1992 • 475 citations

Breast cancer trial with erythropoietin terminated unexpectedly

2003 • 470 citations

Tumor Hypoxia and Malignant Progression

2004 • 464 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo

2003 • 430 citations

Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells

1993 • 424 citations

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury

2002 • 413 citations

Role of apoptosis in reperfusion injury

2004 • 403 citations

Proinflammatory Cytokines Lowering Erythropoietin Production

1998 • 397 citations

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

2002 • 389 citations

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1999 • 388 citations

Erythropoietin Is a Novel Vascular Protectant Through Activation of Akt1 and Mitochondrial Modulation of Cysteine Proteases

2002 • 385 citations

GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression

1999 • 364 citations

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain

2001 • 350 citations

Inactivation of erythropoietin leads to defects in cardiac morphogenesis

1999 • 343 citations

Erythropoietin and VEGF Exhibit Equal Angiogenic Potential

2002 • 326 citations

Erythropoietin and Erythropoietin Receptors in Human CNS Neurons, Astrocytes, Microglia, and Oligodendrocytes Grown in Culture

2001 • 307 citations

Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats

2003 • 304 citations

Erythropoietin Prevents Place Navigation Disability and Cortical Infarction in Rats with Permanent Occlusion of the Middle Cerebral Artery

1998 • 304 citations

Hypoxia-Induced Hyperpermeability in Brain Microvessel Endothelial Cells Involves VEGF-Mediated Changes in the Expression of Zonula Occludens-1

2002 • 299 citations

Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin

2003 • 290 citations

Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus

1998 • 286 citations

Hypoxia and radiation response in human tumors

1996 • 279 citations

Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo

1993 • 275 citations

The cardiovascular effects of erythropoietin

2003 • 274 citations

The molecular mechanism of erythropoietin action

1992 • 274 citations

Neurons and astrocytes express EPO mRNA: Oxygen-sensing mechanisms that involve the redox-state of the brain

2000 • 270 citations

Use of Recombinant Human Erythropoietin Outside the Setting of Uremia

1997 • 269 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Produces Nitric Oxide–Dependent Hypotension

1997 • 268 citations

Impact of hemoglobin level and use of recombinant erythropoietin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx

2001 • 264 citations

Estrogen-dependent Production of Erythropoietin in Uterus and Its Implication in Uterine Angiogenesis

1998 • 263 citations

Erythropoietin regulates tumour growth of human malignancies

2003 • 257 citations

Recombinant human erythropoietin stimulates angiogenesis in vitro

1995 • 252 citations

Erythropoietin both protects from and reverses experimental diabetic neuropathy

2004 • 251 citations

Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway

2003 • 246 citations

Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

1996 • 241 citations

Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation

2000 • 237 citations

Signal Transduction in the Erythropoietin Receptor System

1999 • 227 citations

Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology

2002 • 226 citations

Erythropoietin stimulates proliferation of human renal carcinoma cells

2000 • 223 citations

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

2000 • 211 citations

Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

2002 • 206 citations

Hematopoietic Factor Erythropoietin Fosters Neuroprotection through Novel Signal Transduction Cascades

2002 • 204 citations

Immunohistochemical Localization of Erythropoietin and Its Receptor in the Developing Human Brain

1999 • 200 citations

Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation

2002 • 197 citations

Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells

1993 • 196 citations

Dimerization of the Extracellular Domain of the Erythropoietin (EPO) Receptor by EPO: One High-Affinity and One Low-Affinity Interaction

1996 • 196 citations

Hypoxia-Inducible Erythropoietin Signaling in Squamous Dysplasia and Squamous Cell Carcinoma of the Uterine Cervix and Its Potential Role in Cervical Carcinogenesis and Tumor Progression

2003 • 194 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

Cardioprotective Effects of Erythropoietin in the Reperfused Ischemic Heart

2004 • 187 citations

Effects of Erythropoietin on Neuronal Activity

1999 • 186 citations

Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐x_L expression

2002 • 186 citations

Direct vasopressor effect of recombinant human erythropoietin on renal resistance vessels

1991 • 186 citations

Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage

2002 • 181 citations

Developmental regulation of erythropoietin and erythropoiesis

1997 • 177 citations

Functional Significance of Erythropoietin Receptor Expression in Breast Cancer

2002 • 174 citations

Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy

2002 • 173 citations

NMR structure of human erythropoietin and a comparison with its receptor bound conformation

1998 • 173 citations

Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models

2001 • 163 citations

Detection of erythropoietin in human liquor: Intrinsic erythropoietin production in the brain

1997 • 161 citations

Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8

2002 • 158 citations

Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma

2002 • 153 citations

Regulated Human Erythropoietin Receptor Expression in Mouse Brain

1997 • 151 citations

Role of Vascular Endothelial Growth Factor in Blood-Brain Barrier Breakdown and Angiogenesis in Brain Trauma

1997 • 149 citations

Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways

1995 • 147 citations

Neuroprotection and Angiogenesis: Dual Role of Erythropoietin in Brain Ischemia

2000 • 147 citations

Production and processing of erythropoietin receptor transcripts in brain

2000 • 144 citations

The Pleiotropic Effects of Erythropoietin in the Central Nervous System

2003 • 140 citations

Prior ischemic stress protects against experimental stroke

1993 • 139 citations

Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro

2002 • 133 citations

Hypoxic Preconditioning and Hypoxic‐Ischemic Brain Damage in the Immature Rat: Pathologic and Metabolic Correlates

1998 • 133 citations

Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival

2003 • 132 citations

Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

2001 • 132 citations

Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis

2000 • 132 citations

Anemia, hypoxia and transfusion in patients with cervix cancer: a review

2000 • 131 citations

Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury

2001 • 129 citations

Renal erythropoietin: Properties and production

2006 • 126 citations

Erythropoietin in the Cerebrospinal Fluid of Neonates Who Sustained CNS Injury

1999 • 125 citations

The Role of Tyrosine Phosphorylation in Proliferation and Maturation of Erythroid Progenitor Cells

1997 • 122 citations

Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin

2001 • 118 citations

Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs

2002 • 117 citations

Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids

1996 • 117 citations

Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage

2000 • 114 citations

A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid haemorrhage in rats

2002 • 111 citations

Glycosylation of Erythropoietin Affects Receptor Binding Kinetics: Role of Electrostatic Interactions

2002 • 109 citations

Erythropoietin Depresses Nitric Oxide Synthase Expression by Human Endothelial Cells

1999 • 108 citations

Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers.

2003 • 105 citations

Inhibition of erythropoietin signalling destroys xenografts of ovarian and uterine cancers in nude mice

2001 • 103 citations

Erythropoietin gene expression in different areas of the developing human central nervous system

2000 • 102 citations

Pleiotropic Functions of Erythropoietin.

2003 • 96 citations

Erythropoietin and G-csf Receptors in Human Tumor Cells: Expression and Aspects regarding Functionality

2002 • 96 citations

Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils

2002 • 94 citations

Physiologic Mechanisms of Therapeutic Resistance: Blood Flow and Hypoxia

1995 • 91 citations

Effects of Erythropoietin on Brain Function

2005 • 91 citations

Proteasomes Regulate the Duration of Erythropoietin Receptor Activation by Controlling Down-regulation of Cell Surface Receptors

2000 • 89 citations

Neuroprotective properties of epoetin alfa

2002 • 89 citations

Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage.

2001 • 87 citations

Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity

2000 • 87 citations

Cost-effectiveness of recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia

1998 • 85 citations

Erythropoietin receptor expression in human melanoma cells

2000 • 81 citations

In vivo evidence that erythropoietin has a neuroprotective effect during subarachnoid hemorrhage

2000 • 80 citations

ISSLS Prize Winner: Erythropoietin Inhibits Spinal Neuronal Apoptosis and Pain Following Nerve Root Crush

2003 • 79 citations

Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway

2000 • 78 citations

Signal transduction of erythropoietin in endothelial cells

1996 • 78 citations

The effect of hemoglobin level on radiotherapy outcomes: The Canadian experience

2001 • 77 citations

The impact of epoetin alfa on quality of life during cancer chemotherapy: a fresh look at an old problem.

1997 • 75 citations

NONERYTHROPOIETIC ROLES OF ERYTHROPOIETIN IN THE FETUS AND NEONATE

2000 • 75 citations

Erythropoietin: Cytoprotection in Vascular and Neuronal Cells

2003 • 74 citations

Erythropoietin‐induced excessive erythrocytosis activates the tissue endothelin system in mice

2002 • 73 citations

Use of Recombinant Human Erythropoietin as an Antianemic and Performance Enhancing Drug

2000 • 72 citations

Erythropoietin Receptors Are Expressed in the Central Nervous System of Mid-Trimester Human Fetuses

1996 • 70 citations

Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia

1993 • 69 citations

Mitogenic effect of erythropoietin on neonatal rat cardiomyocytes: Signal transduction pathways

1996 • 69 citations

Erythropoietin is present in the cerebrospinal fluid of neonates

1997 • 68 citations

Physiology and function of the erythropoietin receptor

1998 • 67 citations

Erythropoietin Inhibits Calcium-Induced Neurotransmitter Release from Clonal Neuronal Cells

2000 • 66 citations

Nitric Oxide Metabolism in Erythropoietin-Induced Hypertension

1998 • 66 citations

Erythropoietic, neurotrophic, and angiogenic functions of erythropoietin and regulation of erythropoietin production.

1999 • 65 citations

Effects of Erythropoietin on Endothelin-1 Synthesis and the Cellular Calcium Messenger System in Vascular Endothelial Cells

1997 • 64 citations

Studies on the role of recombinant human erythropoietin in the growth regulation of human nonhematopoietic tumor cells in vitro

1991 • 60 citations

Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivity

2003 • 57 citations

Human recombinant erythropoietin and quality of life: a wonder drug or something to wonder about?

2002 • 55 citations

Erythropoietin induces changes in gene expression in PC-12 cells

2002 • 55 citations

Erythropoietin increases cytosolic free calcium concentration in vascular smooth muscle cells

1993 • 54 citations

Low Doses of EPO Activate MAP Kinases but Not JAK2–STAT5 in Rat Vascular Smooth Muscle Cells

2001 • 53 citations

Erythropoietin induces Ca2+ mobilization and contraction in rat mesangial and aortic smooth muscle cultures.

1996 • 50 citations

Recombinant human erythropoietin in the treatment of cancer-related or chemotherapy-induced anaemia in patients with solid tumours.

1998 • 48 citations

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

2001 • 48 citations

Effect of recombinant human erythropoietin on hematopoietic and non-hematopoietic malignant cell growth in vitro.

1993 • 48 citations

Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin.

2003 • 45 citations

Differential Effects of Endothelin-1 Antagonists on Erythropoietin-Induced Hypertension in Renal Failure

1999 • 44 citations

The Two Proteins of the Erythropoietin Receptor Are Structurally Similar

1989 • 43 citations

Oxygenation of human tumors: the Mainz experience.

1998 • 42 citations

Erythropoietins and Erythropoiesis

2006 • 42 citations

Effect of Erythropoietin on DNA Synthesis, Proto-oncogene Expression and Phospholipase C Activity in Rat Vascular Smooth Muscle Cells

1994 • 42 citations

Altered Pulmonary Vascular Reactivity in Mice with Excessive Erythrocytosis

2004 • 40 citations

Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures

1993 • 40 citations

Endothelin-1 Release by Erythropoietin Involves Calcium Signaling in Endothelial Cells

1995 • 37 citations

Treatment of cancer-related hypercalcemia: The role of gallium nitrate

2003 • 36 citations

Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia

2001 • 35 citations

Does administration of recombinant human erythropoietin attenuate the increase of S-100 protein observed in cerebrospinal fluid after experimental subarachnoid hemorrhage?

2002 • 35 citations

Effects of rHuEpo on cellular proliferation and endothelin-1 production in cultured endothelial cells

1995 • 34 citations

Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia–ischemia rats

2004 • 33 citations

Effects of hypoxia preconditioning on expression of metallothionein-1,2 and heme oxygenase-1 before and after kainic acid-induced seizures.

2000 • 32 citations

Analysis of expression of erythropoietin-binding sites in human lung carcinoma by the biotinylated ligand.

1992 • 32 citations

Effect of 1‐week treatment with erythropoietin on the vascular endothelial function in anaesthetized rabbits

2001 • 32 citations

A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum‐associated degradation

1999 • 31 citations

Erythropoietin in the cerebrospinal fluid of patients with aneurysmal subarachnoid haemorrhage originates from the brain

2003 • 31 citations

Erythropoietin-inducible immediate-early genes in human vascular endothelial cells.

2000 • 30 citations

Hemoglobin level and anemia in radiation oncology: prognostic impact and therapeutic implications.

2000 • 29 citations

Direct evidence for erythropoietin-induced release of endothelin from peripheral vascular tissue

1994 • 28 citations

Chronic erythropoietin treatment enhances endogenous nitric oxide production in rats

1997 • 28 citations

Erythropoietin improves cardiac contractility in post‐hypoxic mice

2003 • 27 citations

Plasma erythropoietin concentrations in patients receiving intensive platinum or nonplatinum chemotherapy

2000 • 27 citations

The effect of human recombinant erythropoietin on the growth of a human neuroblastoma cell line

1996 • 25 citations

Elevated Levels of Erythropoietin in Cerebrospinal Fluid of Depressed Patients

1998 • 25 citations

Endothelin-mediated effect of erythropoietin on blood pressure and renal hemodynamics in hypertensive rats

1996 • 25 citations

rHuEPO enhances the production of plasminogen activator inhibitor-1 in cultured endothelial cells

1996 • 24 citations

Involvement of erythropoietin-induced cytosolic free calcium mobilization in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cells

2001 • 23 citations

Immunolocalization of Erythropoietin and Erythropoietin Receptor in Vestibular Schwannoma

2001 • 23 citations

Autocrine regulation of erythropoietin gene expression in human hepatocellular carcinoma cells

1995 • 22 citations

Erythropoietic agents as neurotherapeutic agents: what barriers exist?

2002 • 21 citations

Plasma endothelin in haemodialysis patients treated with recombinant human erythropoietin

1994 • 20 citations

INFLUENCE OF ALKYLATING AGENTS ON KIDNEY ERYTHROPOIETIN PRODUCTION.

1964 • 20 citations

Recombinant human erythropoietin stimulates vascular endothelial growth factor release by glomerular endothelial cells

1999 • 19 citations

Erythropoietin upregulates the expression of its own receptor in TF-1 cell line

1998 • 19 citations

Plasma and Blood Vessel Endothelin-1 Concentrations in Hypertensive Uremic Rats Treated with Erythropoietin

1998 • 18 citations

Relationship between erythropoietin and nitric oxide in the contraction of rat renal arcuate arteries and human umbilical vein endothelial cells

1999 • 18 citations

Erythropoietin as a critical component of breast cancer therapy: survival, synergistic, and cognitive applications

2003 • 18 citations

Erythropoietin and Blood Pressure

1989 • 17 citations

Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility

1994 • 16 citations

Erythropoietin Receptor in Myelodysplastic Syndrome and Leukemia

2002 • 15 citations

Effect of recombinant human erythropoietin on the growth of human tumor cell lines in vitro. Micro-titertec-tetrazolium assay.

1992 • 15 citations

Autocrine stimulation by erythropoietin in transgenic mice results in erythroid proliferation without neoplastic transformation☆☆Supported in part by National Institutes of Health Grants KO8 HL02966 (A.M.) and R29 DK44956 (P.T.C.) and by a Medical Research Foundation of Oregon grant (P.T.C.).

2003 • 12 citations

Modulation of Endothelin-1-Induced Cytosolic Free Calcium Mobilization and Mitogen-Activated Protein Kinase Activation by Erythropoietin in Vascular Smooth Muscle Cells

2001 • 8 citations

Signal Transduction in Primary Culture Human Erythroid Cells

2000 • 7 citations

Effects of Recombinant Human Erythropoietin on Clonogenic Growth of Primary Human Tumor Specimens in vitro

1992 • 7 citations