A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum‐associated degradation

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Endocytosis

1997 • 1,263 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1

1996 • 379 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity

1990 • 325 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

A Di-leucine Motif and an Upstream Serine in the Interleukin-6 (IL-6) Signal Transducer gp130 Mediate Ligand-induced Endocytosis and Down-regulation of the IL-6 Receptor

1996 • 168 citations

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain

1995 • 151 citations

The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes

1994 • 145 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 133 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells.

1995 • 130 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 101 citations

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

1997 • 100 citations

STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line

1997 • 90 citations

The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: evidence for differentiation stage-specific regulation.

1992 • 87 citations

Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.

1994 • 85 citations

Physical and functional interactions between Stat5 and the tyrosine- phosphorylated receptors for erythropoietin and interleukin-3

1996 • 82 citations

Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.

1995 • 80 citations

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes

1993 • 75 citations

The functional form of the erythropoietin receptor is a 78-kDa protein: correlation with cell surface expression, endocytosis, and phosphorylation.

1993 • 74 citations

Precise large deletions by the PCR-based overlap extension method

1995 • 71 citations

Association of JAK2 and STAT5 with Erythropoietin Receptors

1996 • 67 citations

Physiology and function of the erythropoietin receptor

1998 • 67 citations

Dual Role of a Dileucine Motif in Insulin Receptor Endocytosis

1997 • 59 citations

The Cytoplasmic Juxtamembrane Domain of the Epidermal Growth Factor Receptor Contains a Novel Autonomous Basolateral Sorting Determinant

1997 • 58 citations

Proliferation and erythroid differentiation through the cytoplasmic domain of the erythropoietin receptor.

1994 • 56 citations

Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor.

1995 • 53 citations

Cytoplasmic juxtamembrane domain of the human EGF receptor is required for basolateral localization in MDCK cells

1995 • 53 citations

Transfer of functional EGF receptors to an IL3‐dependent cell line

1988 • 53 citations

An α-Helical Signal in the Cytosolic Domain of the Interleukin 2 Receptor β Chain Mediates Sorting Towards Degradation after Endocytosis

1997 • 52 citations

Biosynthesis of the epidermal growth factor receptor in human epidermoid carcinoma-derived A431 cells.

1984 • 51 citations

Lysosomal Targeting of P-selectin Is Mediated by a Novel Sequence within Its Cytoplasmic Tail

1998 • 50 citations

Proteasome inhibitors and antigen presentation

1997 • 45 citations

Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum.

1993 • 40 citations

Endocytosis of the Common Cytokine Receptor γcChain

1998 • 36 citations

Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization

1998 • 31 citations

Phosphorylation of erythropoietin receptors in the endoplasmic reticulum by pervanadate-mediated inhibition of tyrosine phosphatases

1997 • 26 citations

Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms

1996 • 26 citations

Intracellular degradation of secretion defect‐type mutants of antithrombin is inhibited by proteasomal inhibitors

1997 • 25 citations

Regulation of Expression of the Human Erythropoietin Receptor Gene

1996 • 18 citations

Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells

1992 • 5 citations