Collagenase in Rheumatoid Arthritis

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.

1978 • 719 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

Purification of rabbit bone inhibitor of collagenase

1981 • 352 citations

Human Granulocyte Collagenase

1968 • 335 citations

[54] α2-Macroglobulin

1981 • 316 citations

Collagen-and collagen peptide-induced chemotaxis of human blood monocytes.

1976 • 312 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells.

1979 • 283 citations

Collagenase Production by Rheumatoid Synovial Cells: Stimulation by a Human Lymphocyte Factor

1977 • 275 citations

Human skin fibroblast collagenase inhibitor. Purification and biochemical characterization.

1983 • 259 citations

A cartilage catabolic factor from synovium

1979 • 246 citations

Histopathology of the rheumatoid lesion

1984 • 241 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Native cross-links in collagen fibrils induce resistance to human synovial collagenase

1979 • 217 citations

Collagenases in human synovial fluid

1969 • 215 citations

Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin

1983 • 208 citations

Granulocyte collagenase: selective digestion of type I relative to type III collagen.

1977 • 201 citations

Human Collagenase: Identification and Characterization of an Enzyme from Rheumatoid Synovium in Culture

1967 • 197 citations

The Influence of Temperature and Fibril Stability on Degradation of Cartilage Collagen by Rheumatoid Synovial Collagenase

1974 • 187 citations

STIMULATION BY ENDOCYTOSIS OF THE SECRETION OF COLLAGENASE AND NEUTRAL PROTEINASE FROM RABBIT SYNOVIAL FIBROBLASTS

1974 • 180 citations

Human skin fibroblast collagenase: chemical properties of precursor and active forms

1978 • 175 citations

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

1981 • 171 citations

A specific collagenase from rabbit fibroblasts in monolayer culture

1974 • 168 citations

Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells

1980 • 164 citations

Small molecular weight β1 serum protein which specifically inhibits human collagenases

1976 • 147 citations

Collagenase inhibition by cationic proteins derived from cartilage and aorta

1976 • 143 citations

Collagenase production by synovial fibroblasts treated with phorbol myristate acetate

1979 • 139 citations

Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

1981 • 138 citations

Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium.

1983 • 134 citations

Synthesis of collagenase and neutral proteases by articular chondrocytes: Stimulation by a macrophage-derived factor

1978 • 132 citations

Binding of maytansine to rat brain tubulin

1976 • 123 citations

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments.

1980 • 122 citations

Inflammation and Collagenase Production in Rats with Adjuvant Arthritis Reduced with 13- cis -Retinoic Acid

1983 • 121 citations

Release of Collagenase, Neutral Protease, and Prostaglandins From Cultured Mammalian Synovial Cells by Hydroxyapatite and Calcium Pyrophosphate Dihydrate Crystals

1981 • 117 citations

Human skin fibroblast collagenase. Assessment of activation energy and deuterium isotope effect with collagenous substrates.

1981 • 117 citations

Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage.

1977 • 109 citations

Proteases induce secretion of collagenase and plasminogen activator by fibroblasts

1978 • 102 citations

Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase

1983 • 102 citations

Activation of leucocyte collagenase proenzyme by rheumatoid synovial fluid

1972 • 93 citations

Inhibitor of human collagenase from cultures of human tendon.

1979 • 91 citations

Induction of the synthesis of latent collagenase and latent neutral protease in chondrocytes by a factor synthesized by activated macrophages

1980 • 90 citations

A precursor form of latent collagenase produced in a cell-free system with mRNA from rabbit synovial cells.

1981 • 88 citations

Latent and Active Human Polymorphonuclear Leukocyte Collagenases

1983 • 87 citations

Metalloproteinases and collagenase inhibitors in rheumatoid synovial fluid

1984 • 86 citations

Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro

1983 • 81 citations

Stimulation of collagenase production by collagen in mammalian cell cultures

1979 • 78 citations

Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid

1982 • 73 citations

Inhibition of Bone Resorption in Vitro by a Cartilage-Derived Anticollagenase Factor

1978 • 66 citations

Evidence for the Presence of a Latent Form of Collagenase in Human Rheumatoid Synovial Fluid

1972 • 63 citations

Secretion of Collagenolytic Enzymes by Human Polymorphonuclear Leukocytes

1984 • 59 citations

Characterization of Collagenase, other Metallo-Proteinases and An Inhibitor (Timp) Produced by Human Synovium and Cartilage in Culture

1981 • 55 citations

Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells

1983 • 54 citations

The role of collagen autoimmunity in animal models and human diseases.

1982 • 46 citations

Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor.

1982 • 43 citations

Augmentation of collagen arthritis by synthetic analogues of retinoic acid.

1982 • 39 citations

Iron increases collagenase production by rabbit synovial fibroblasts.

1981 • 39 citations

Neutral proteinases from articular chondrocytes in culture. I. A latent collagenase that degrades human cartilage type II collagen

1981 • 30 citations

Collagenase in synovial fluid.

1978 • 19 citations

A latent collagenase from rheumatoid synovial fluid Purification and partial characterization

1980 • 18 citations

Collagen degradation and mammalian collagenase

1982 • 17 citations

Experimental synovitis induced by intraarticular administration of α₂‐macroglobulin‐proteinase complexes

1984 • 9 citations

Experimental Arthritis Induced by Granulocyte Collagenase

1980 • 5 citations