Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors

β-Arrestins and Cell Signaling

2007 • 1,341 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

Identification of a serotonin/glutamate receptor complex implicated in psychosis

2008 • 757 citations

Opioid Receptors

2004 • 650 citations

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a G_sLinkage to the CB1 Receptor

1997 • 623 citations

Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor

2004 • 487 citations

Pharmacology of Cannabinoid Receptors

1995 • 485 citations

Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation

2006 • 451 citations

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

2004 • 441 citations

Cannabinoid Receptor Signaling

2005 • 425 citations

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

2001 • 397 citations

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

2006 • 390 citations

Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration

2001 • 367 citations

The evasive nature of drug efficacy: implications for drug discovery

2007 • 351 citations

Ultrastructural Localization of the CB1 Cannabinoid Receptor in μ-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus

2001 • 343 citations

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?

2005 • 342 citations

G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways

1998 • 318 citations

μ opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis

2006 • 298 citations

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

2008 • 249 citations

Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: a Current Perspective: TABLE 1

2003 • 245 citations

Compartment-specific localization of cannabinoid 1 (CB1) and μ-opioid receptors in rat nucleus accumbens

2004 • 241 citations

Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function

2006 • 216 citations

Efficacy as a Vector: the Relative Prevalence and Paucity of Inverse Agonism

2004 • 207 citations

Constitutive Activation Drives Compartment-Selective Endocytosis and Axonal Targeting of Type 1 Cannabinoid Receptors

2006 • 199 citations

G protein-coupled receptor signalling and cross-talk

2002 • 194 citations

Principles: Extending the utility of [35S]GTPγS binding assays

2003 • 186 citations

Hypersensitization of the Orexin 1 Receptor by the CB1 Receptor

2003 • 184 citations

Motivational Effects of Cannabinoids and Opioids on Food Reinforcement Depend on Simultaneous Activation of Cannabinoid and Opioid Systems

2005 • 177 citations

Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB₁ and CB₂ receptors

1998 • 176 citations

G protein-coupled receptor dimerisation: Molecular basis and relevance to function

2006 • 168 citations

The α_1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function

2007 • 159 citations

CB1-cannabinoid and μ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn

2001 • 152 citations

G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery

2006 • 130 citations

Interactions between CB1 cannabinoid and μ opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core

2006 • 119 citations

Endocytosis of the Viral Chemokine Receptor US28 Does Not Require Beta‐Arrestins But Is Dependent on the Clathrin‐Mediated Pathway

2003 • 108 citations

Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling.

1998 • 101 citations

Involvement of the Carboxyl Terminus of the Third Intracellular Loop of the Cannabinoid CB1 Receptor in Constitutive Activation of G_s

1999 • 98 citations

Virally encoded 7TM receptors

2001 • 95 citations

Opioid and Cannabinoid Receptor Inhibition of Adenylyl Cyclase in Braina

1992 • 94 citations

Up-regulation of the Angiotensin II Type 1 Receptor by the MAS Proto-oncogene Is Due to Constitutive Activation of Gq/G11 by MAS

2006 • 90 citations

An Essential Role for Constitutive Endocytosis, but Not Activity, in the Axonal Targeting of the CB₁ Cannabinoid Receptor

2006 • 84 citations

Structural Domains of the CB1 Cannabinoid Receptor That Contribute to Constitutive Activity and G-Protein Sequestration

2001 • 82 citations

GPCR dimerisation

2003 • 81 citations

Mu Opioid Receptor Activation of ERK1/2 Is GRK3 and Arrestin Dependent in Striatal Neurons

2006 • 80 citations

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

1996 • 80 citations

The Role of Diacylglycerol Lipase in Constitutive and Angiotensin AT1 Receptor-stimulated Cannabinoid CB1 Receptor Activity

2007 • 75 citations

Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD

2005 • 75 citations

Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor ‘silent antagonist’

2005 • 67 citations

A Mutation in the Second Transmembrane Region of the CB1 Receptor Selectively Disrupts G Protein Signaling and Prevents Receptor Internalization

1999 • 66 citations

Protean Agonism at the Dopamine D₂ Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of G_o1 but an Antagonist/Inverse Agonist for G_i1,G_i2, and G_i3

2007 • 65 citations

Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq α/G11 α following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

1993 • 60 citations

Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance

2007 • 60 citations

Concurrent down-regulation of IP prostanoid receptors and the α-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma × glioma cells to prostanoid agonists. Quantification and functional implications

1992 • 59 citations

Identification of Two Distinct Isoforms of the Guanine Nucleotide Binding Protein G_o in Neuroblastoma × Glioma Hybrid Cells: Independent Regulation During Cyclic AMP‐Induced Differentiation

1990 • 58 citations

Molecular Mechanisms of Opiate Receptor Coupling to G Proteins and Effector Systems^a

1996 • 55 citations

Regulation of Spontaneous Activity of the δ‐Opioid Receptor: Studies of Inverse Agonism in Intact Cells

1997 • 48 citations

Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?

2007 • 44 citations

Extracellular Signal-Regulated Kinase 1/2-Mediated Transcriptional Regulation of G-Protein-Coupled Receptor Kinase 3 Expression in Neuronal Cells

2007 • 17 citations

Assay of G Protein-Coupled Receptor Activation of G Proteins in Native Cell Membranes Using [<SUP>35</SUP>S]GTPγS Binding

2003 • 16 citations

[21] Specificity and functional applications of antipeptide antisera which identify G-protein α subunits

1994 • 14 citations