G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery

A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels

1999 • 1,038 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

The G protein-coupled receptor repertoires of human and mouse

2003 • 747 citations

Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

2003 • 591 citations

G-Protein-coupled receptor oligomerization and its potential for drug discovery

2002 • 584 citations

The human olfactory receptor gene family

2004 • 576 citations

Oligomerization of μ- and δ-Opioid Receptors

2000 • 545 citations

G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology

2004 • 467 citations

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

2004 • 453 citations

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

2005 • 435 citations

Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization

2003 • 424 citations

G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor

2005 • 400 citations

A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia

2004 • 380 citations

Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance

2005 • 371 citations

Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

2002 • 335 citations

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

2005 • 333 citations

Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation

2000 • 326 citations

Ligand-selective receptor conformations revisited: the promise and the problem

2003 • 319 citations

Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation

2005 • 282 citations

Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein

2003 • 270 citations

Oligomerization of G Protein-Coupled Receptors: Past, Present, and Future

2004 • 229 citations

The G protein‐coupled receptor rhodopsin in the native membrane

2004 • 224 citations

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

2006 • 220 citations

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

2002 • 207 citations

Methods to monitor the quaternary structure of G protein‐coupled receptors

2005 • 206 citations

G Protein–Coupled Receptor Oligomerization

2004 • 193 citations

Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers

2004 • 186 citations

Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells

2004 • 186 citations

Hypersensitization of the Orexin 1 Receptor by the CB1 Receptor

2003 • 184 citations

G protein coupled receptor dimerization: implications in modulating receptor function

2001 • 173 citations

High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay

2005 • 173 citations

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

2003 • 169 citations

Dimerization of G-protein-coupled receptors: roles in signal transduction

2003 • 166 citations

Opioids and Their Complicated Receptor Complexes

2000 • 165 citations

Evidence for a Functional Interaction of the Angiotensin-(1–7) Receptor Mas With AT ₁ and AT ₂ Receptors in the Mouse Heart

2005 • 165 citations

Opioid Receptor Homo- and Heterodimerization in Living Cells by Quantitative Bioluminescence Resonance Energy Transfer

2005 • 161 citations

Hetero-oligomerization between β2- and β3-Adrenergic Receptors Generates a β-Adrenergic Signaling Unit with Distinct Functional Properties

2004 • 151 citations

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with β-arrestin and their trafficking patterns

2004 • 147 citations

Real-time monitoring of ubiquitination in living cells by BRET

2004 • 145 citations

Adenosine A2A-dopamine D2 receptor–receptor heteromers. Targets for neuro-psychiatric disorders

2004 • 140 citations

Oligomerization, Biogenesis, and Signaling Is Promoted by a Glycophorin A-like Dimerization Motif in Transmembrane Domain 1 of a Yeast G Protein-coupled Receptor

2003 • 136 citations

The CXCR1 and CXCR2 Receptors Form Constitutive Homo- and Heterodimers Selectively and with Equal Apparent Affinities

2005 • 133 citations

C5a Receptor Oligomerization

2003 • 132 citations

Domain swapping in G-protein coupled receptor dimers

1998 • 127 citations

Dimers of Class A G Protein-coupled Receptors Function via Agonist-mediated Trans-activation of Associated G Proteins

2003 • 111 citations

Heterodimerization of μ- and δ-Opioid Receptors Occurs at the Cell Surface Only and Requires Receptor-G Protein Interactions

2005 • 111 citations

Multiple Interactions between Transmembrane Helices Generate the Oligomeric α_1b-Adrenoceptor

2004 • 100 citations

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors

2004 • 97 citations

Heterodimerization of β ₁ - and β ₂ -Adrenergic Receptor Subtypes Optimizes β-Adrenergic Modulation of Cardiac Contractility

2005 • 97 citations

Mesangial AT<SUB>1</SUB>/B<SUB>2</SUB> Receptor Heterodimers Contribute to Angiotensin II Hyperresponsiveness in Experimental Hypertension

2005 • 89 citations

Quantitative Analysis of Muscarinic Acetylcholine Receptor Homo- and Heterodimerization in Live Cells

2005 • 89 citations

An Opiate Cocktail that Reduces Morphine Tolerance and Dependence

2005 • 87 citations

Development of a BRET2 Screening Assay Using β-Arrestin 2 Mutants

2004 • 84 citations

Oligomerization of Wild Type and Nonfunctional Mutant Angiotensin II Type I Receptors Inhibits Gαq Protein Signaling but Not ERK Activation

2004 • 77 citations

Domain Swapping in the Human Histamine H₁Receptor

2004 • 76 citations

Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD

2005 • 75 citations

Interaction of Bivalent Ligand KDN21 with Heterodimeric δ-κ Opioid Receptors in Human Embryonic Kidney 293 Cells

2005 • 73 citations

Potent activation of dopamine D₃/D₂ heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole

2003 • 71 citations

Homo-oligomeric Complexes of the Yeast α-Factor Pheromone Receptor Are Functional Units of Endocytosis

2000 • 69 citations

High-content assays for ligand regulation of G-protein-coupled receptors

2003 • 67 citations

Oligomeric potential of the M₂ muscarinic cholinergic receptor

2004 • 60 citations

Blocking receptors on the inside: pepducin-based intervention of PAR signaling and thrombosis

2003 • 60 citations

AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia

2004 • 54 citations

Paired Activation of Two Components within Muscarinic M3 Receptor Dimers Is Required for Recruitment of β-Arrestin-1 to the Plasma Membrane

2005 • 51 citations

Oligomerization of the fifth transmembrane domain from the adenosine A_2A receptor

2005 • 51 citations

Cooperativity and Oligomeric Status of Cardiac Muscarinic Cholinergic Receptors

2002 • 47 citations

Promiscuous Coupling at Receptor-Gα Fusion Proteins

2003 • 46 citations

Functional Complementation and the Analysis of Opioid Receptor Homodimerization

2005 • 45 citations

G-Protein Coupled Receptors as Allosteric Machines

2004 • 45 citations

Investigation of Cooperativity in the Binding of Ligands to the D₂Dopamine Receptor

2005 • 43 citations

Functional consequences of 7TM receptor dimerization

2004 • 34 citations

The Composition of the β-2 Adrenergic Receptor Oligomer Affects Its Membrane Trafficking after Ligand-Induced Endocytosis

2004 • 32 citations

Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo

2003 • 29 citations

Current methods used to investigate G protein coupled receptor oligomerisation

2005 • 27 citations

Analysis of endogenous S1P and LPA receptor expression in CHO-K1 cells

2005 • 21 citations

Existence and Theoretical Aspects of Homomeric and Heteromeric Dopamine Receptor Complexes and Their Relevance for Neurological Diseases

2005 • 21 citations

Pepducins: an effective means to inhibit GPCR signaling by neutrophils

2005 • 10 citations