Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Transduction of Receptor Signals by ß-Arrestins

2005 • 1,656 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

2001 • 808 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

2003 • 655 citations

Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration*

1982 • 620 citations

Desensitization of G-protein-coupled Receptors

1999 • 510 citations

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

2003 • 497 citations

Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor

2004 • 487 citations

Inverse, protean, and ligand‐selective agonism: matters of receptor conformation

2001 • 403 citations

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

2001 • 397 citations

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

2002 • 386 citations

Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone

1992 • 364 citations

Parathyroid hormone: a double-edged sword for bone metabolism

2004 • 260 citations

Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1

1997 • 238 citations

X-ray crystal structure of arrestin from bovine rod outer segments

1998 • 236 citations

Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference

2003 • 232 citations

Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi

2002 • 199 citations

Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells

1993 • 193 citations

Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by β-Arrestins 1 and 2

2004 • 170 citations

Signaling at zero G: G-protein-independent functions for 7-TM receptors

2001 • 163 citations

Endocytosis of Ligand-Human Parathyroid Hormone Receptor 1 Complexes Is Protein Kinase C-dependent and Involves β-Arrestin2

1999 • 144 citations

Stimulation of Extracellular Signal-regulated Kinases and Proliferation in Rat Osteoblastic Cells by Parathyroid Hormone Is Protein Kinase C-dependent

2001 • 136 citations

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases

1999 • 134 citations

Mutations in the Second Cytoplasmic Loop of the Rat Parathyroid Hormone (PTH)/PTH-related Protein Receptor Result in Selective Loss of PTH-stimulated Phospholipase C Activity

1997 • 132 citations

Bone Response to Intermittent Parathyroid Hormone Is Altered in Mice Null for β-Arrestin2

2005 • 127 citations

Differential Conformational Requirements for Activation of G Proteins and the Regulatory Proteins Arrestin and G Protein-coupled Receptor Kinase in the G Protein-coupled Receptor for Parathyroid Hormone (PTH)/PTH-related Protein

2001 • 107 citations

Amino-Terminal Modifications of Human Parathyroid Hormone (PTH) Selectively Alter Phospholipase C Signaling via the Type 1 PTH Receptor: Implications for Design of Signal-Specific PTH Ligands

1999 • 102 citations

Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations

2002 • 95 citations

Multiple Independent Functions of Arrestins in the Regulation of Protease-Activated Receptor-2 Signaling and Trafficking

2004 • 94 citations

Homo- and Hetero-oligomerization of β-Arrestins in Living Cells

2005 • 92 citations

Parathyroid Hormone Activates Mitogen-activated Protein Kinase via a cAMP-mediated Pathway Independent of Ras

1997 • 90 citations

Parathyroid Hormone Stimulates Extracellular Signal-Regulated Kinase (ERK) Activity Through Two Independent Signal Transduction Pathways

2000 • 78 citations

Parathyroid Hormone Activates Mitogen-Activated Protein Kinase in Opossum Kidney Cells

1999 • 77 citations

Visual Arrestin Activity May Be Regulated by Self-association

1999 • 77 citations

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.

1996 • 74 citations

β-Arrestin2 Regulates the Differential Response of Cortical and Trabecular Bone to Intermittent PTH in Female Mice

2005 • 73 citations

Constitutive Activation of the Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway by Parathyroid Hormone (PTH)/PTH-Related Peptide Receptors Mutated at the Two Loci for Jansen’s Metaphyseal Chondrodysplasia

1997 • 69 citations

Structurally Diverse N-terminal Peptides of Parathyroid Hormone (PTH) and PTH-related Peptide (PTHRP) Inhibit the Na+/H+ Exchanger NHE3 Isoform by Binding to the PTH/PTHRP Receptor Type I and Activating Distinct Signaling Pathways

1996 • 64 citations

Cellular Distribution of Constitutively Active Mutant Parathyroid Hormone (PTH)/PTH-Related Protein Receptors and Regulation of Cyclic Adenosine 3′,5′-Monophosphate Signaling by β-Arrestin2

2001 • 54 citations

Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells.

1992 • 46 citations

Parathyroid hormone-related protein increases DNA synthesis in proximal tubule cells by cyclic AMP- and protein kinase C-dependent pathways

1998 • 15 citations