Stochasticity in gene expression: from theories to phenotypes

Stochastic Processes in Physics and Chemistry

2007 • 9,372 citations

Network biology: understanding the cell's functional organization

2004 • 7,596 citations

Stochastic Gene Expression in a Single Cell

2002 • 5,397 citations

A synthetic oscillatory network of transcriptional regulators

2000 • 4,543 citations

Construction of a genetic toggle switch in Escherichia coli

2000 • 4,184 citations

Stochastic Processes in Physics and Chemistry

1992 • 3,278 citations

Bacterial Persistence as a Phenotypic Switch

2004 • 2,806 citations

Biological robustness

2004 • 2,025 citations

Stochastic mechanisms in gene expression

1997 • 1,860 citations

Noise in eukaryotic gene expression

2003 • 1,694 citations

Intrinsic and extrinsic contributions to stochasticity in gene expression

2002 • 1,662 citations

Regulation of noise in the expression of a single gene

2002 • 1,566 citations

Engineering stability in gene networks by autoregulation

2000 • 1,542 citations

Robustness in simple biochemical networks

1997 • 1,531 citations

Stochastic Kinetic Analysis of Developmental Pathway Bifurcation in Phage λ-Infected Escherichia coli Cells

1998 • 1,519 citations

Intrinsic noise in gene regulatory networks

2001 • 1,461 citations

Control of Stochasticity in Eukaryotic Gene Expression

2004 • 1,448 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Summing up the noise in gene networks

2004 • 1,295 citations

Robustness in bacterial chemotaxis

1999 • 1,147 citations

Gene Regulation at the Single-Cell Level

2005 • 1,116 citations

Epigenetic mechanisms of gene regulation

1996 • 1,097 citations

Robustness of Cellular Functions

2004 • 1,051 citations

Multistability in the lactose utilization network of Escherichia coli

2004 • 1,043 citations

Control, exploitation and tolerance of intracellular noise

2002 • 1,030 citations

Dynamics of the p53-Mdm2 feedback loop in individual cells

2004 • 984 citations

Stochasticity in Transcriptional Regulation: Origins, Consequences, and Mathematical Representations

2001 • 928 citations

A Unified Theory of Gene Expression

2002 • 896 citations

ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON

1957 • 892 citations

It’s a noisy business! Genetic regulation at the nanomolar scale

1999 • 873 citations

Noise Propagation in Gene Networks

2005 • 819 citations

Autoinhibition with Transcriptional Delay

2003 • 741 citations

Development of Genetic Circuitry Exhibiting Toggle Switch or Oscillatory Behavior in Escherichia coli

2003 • 729 citations

Programmed population control by cell–cell communication and regulated killing

2004 • 708 citations

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

2001 • 706 citations

Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays

2003 • 696 citations

Illegitimate transcription: transcription of any gene in any cell type.

1989 • 647 citations

Markovian Modeling of Gene-Product Synthesis

1995 • 645 citations

Mechanisms of noise-resistance in genetic oscillators

2002 • 620 citations

Noise-based switches and amplifiers for gene expression

2000 • 609 citations

Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

2003 • 608 citations

Programmed Death in Bacteria

2000 • 602 citations

Programmable cells: Interfacing natural and engineered gene networks

2004 • 596 citations

Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

2000 • 584 citations

Stochastic Gene Expression in Fluctuating Environments

2004 • 547 citations

Circadian clocks limited by noise

2000 • 542 citations

Non-genetic individuality: chance in the single cell

1976 • 528 citations

The Segmentation Clock: Converting Embryonic Time into Spatial Pattern

2003 • 523 citations

Ultrasensitivity and noise propagation in a synthetic transcriptional cascade

2005 • 506 citations

Enhancement of cellular memory by reducing stochastic transitions

2005 • 505 citations

Sampling Rare Switching Events in Biochemical Networks

2005 • 465 citations

Gene number, noise reduction and biological complexity

1995 • 462 citations

Prediction and measurement of an autoregulatory genetic module

2003 • 452 citations

From molecular noise to behavioural variability in a single bacterium

2004 • 434 citations

Noise Minimization in Eukaryotic Gene Expression

2004 • 430 citations

Robustness of circadian rhythms with respect to molecular noise

2002 • 401 citations

Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation

2000 • 393 citations

An engineered epigenetic transgene switch in mammalian cells

2004 • 343 citations

Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock

2003 • 326 citations

Stochastic gene expression as a many-body problem

2003 • 298 citations

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

2003 • 289 citations

A model for the statistical fluctuations of protein numbers in a microbial population

1978 • 271 citations

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

Evidence that hematopoiesis may be a stochastic process in vivo

1996 • 258 citations

Statistical Fluctuations in Autocatalytic Reactions

1940 • 247 citations

Modeling stochastic gene expression: Implications for haploinsufficiency

1998 • 244 citations

Attenuation of Noise in Ultrasensitive Signaling Cascades

2002 • 233 citations

Efficient Attenuation of Stochasticity in Gene Expression Through Post-transcriptional Control

2004 • 225 citations

Frequency domain analysis of noise in autoregulated gene circuits

2003 • 218 citations

Do Stem Cells Play Dice?

1998 • 212 citations

Comparison of classical and autogenous systems of regulation in inducible operons

1974 • 212 citations

Cell signaling can direct either binary or graded transcriptional responses

2001 • 207 citations

Stress and the single cell: Intrapopulation diversity is a mechanism to ensure survival upon exposure to stress

2002 • 206 citations

A stochastic model for gene induction

1991 • 198 citations

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

2000 • 197 citations

Transcription factor haploinsufficiency: when half a loaf is not enough

2002 • 195 citations

The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.

1990 • 194 citations

Noise in a minimal regulatory network: plasmid copy number control

2001 • 174 citations

Do Stem Cells Play Dice?

1998 • 171 citations

Stochastic simulation of the mammalian circadian clock

2004 • 170 citations

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

2000 • 169 citations

The marks, mechanisms and memory of epigenetic states in mammals

2001 • 167 citations

The Effect of Transcription and Translation Initiation Frequencies on the Stochastic Fluctuations in Prokaryotic Gene Expression

2001 • 167 citations

Stress and How Bacteria Cope with Death and Survival

2004 • 167 citations

Noisy signal amplification in ultrasensitive signal transduction

2004 • 162 citations

A Notch feeling of somite segmentation and beyond

2003 • 159 citations

A THEORETICAL AND EXPERIMENTAL STUDY

1996 • 157 citations

Transcription factor haploinsufficiency: when half a loaf is not enough

2002 • 157 citations

An Outline of the Pattern of Bacterial Generation Times

1958 • 150 citations

On the relation between fluctuation and response in biological systems

2003 • 148 citations

The consequences of imperfect mixing in autocatalytic chemical and biological systems

1995 • 147 citations

Modulation of a Transcription Factor Counteracts Heterochromatic Gene Silencing in Drosophila

2001 • 147 citations

Transcription of individual genes in eukaryotic cells occurs randomly and infrequently

1994 • 144 citations

Notch signalling in development: on equivalence groups and asymmetric developmental potential

1997 • 144 citations

Independent regulation of the two Pax5 alleles during B-cell development

1999 • 142 citations

Haploinsufficiency at the Nkx3.1 locus

2003 • 142 citations

Switching to IgG3, IgG2b, and IgA Is Division Linked and Independent, Revealing a Stochastic Framework for Describing Differentiation

1999 • 141 citations

To be or not to be active: the stochastic nature of enhancer action

2000 • 141 citations

Transcription Factor Dosage Affects Changes in Higher Order Chromatin Structure Associated with Activation of a Heterochromatic Gene

2000 • 124 citations

DNA Methylation Density Influences the Stability of an Epigenetic Imprint and Dnmt3a/b-Independent De Novo Methylation

2002 • 123 citations

Problems and paradigms: Induction mechanism of a single gene molecule: Stochastic or deterministic?

1992 • 114 citations

The marks, mechanisms and memory of epigenetic states in mammals

2001 • 102 citations

Response of complex networks to stimuli

2004 • 101 citations

Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro

2002 • 96 citations

A Darwinian theory for the origin of cellular differentiation

1997 • 93 citations

Distribution of suboptimally induced β-d-galactosidase in Escherichia coli

1973 • 92 citations

Optimal path to epigenetic switching

2005 • 89 citations

A Genetic Switch in Pancreatic β-Cells

2002 • 87 citations

Frequency domain chemical Langevin analysis of stochasticity in gene transcriptional regulation

2004 • 85 citations

Graded and binary responses in stochastic gene expression

2004 • 72 citations

Control of internal and external noise in genetic regulatory networks

2004 • 66 citations

Multivariate analysis of noise in genetic regulatory networks

2004 • 66 citations

Stochastic gene expression during cell differentiation: order from disorder?

2003 • 66 citations

Stochastic model of linear, continuous protein synthesis in bacterial populations

1977 • 64 citations

Modeling embryogenesis and cancer: an approach based on an equilibrium between the autostabilization of stochastic gene expression and the interdependence of cells for proliferation

2004 • 62 citations

Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

2003 • 62 citations

High local protein concentrations at promoters: Strategies in prokaryotic and eukaryotic cells

2001 • 60 citations

Binary and Graded Responses in Gene Networks

2002 • 60 citations

Insulator dynamics and the setting of chromatin domains

2004 • 57 citations

Simultaneously Monitoring Gene Expression Kinetics and Genetic Noise in Single Cells by Optical Well Arrays

2004 • 55 citations

The origin of hematopoietic cell type diversity

2004 • 55 citations

Investigating Autocatalytic Gene Expression Systems through Mechanistic Modeling

1999 • 54 citations

Internal noise stochastic resonance of synthetic gene network

2004 • 54 citations

Constructive effects of fluctuations in genetic and biochemical regulatory systems

2003 • 53 citations

Refinement of gene expression patterns in the earlyXenopusembryo

2004 • 53 citations

Self-organization vs Watchmaker: stochastic gene expression and cell differentiation

2004 • 49 citations

Fifteen Minutes offim: Control of Type 1 Pili Expression inE. coli

2002 • 46 citations

Intrinsic and external noise in an auto-regulatory genetic network

2004 • 46 citations

Morphogen Gradient from a Noisy Source

2005 • 45 citations

Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene

1998 • 44 citations

Robust control in bacterial regulatory circuits

2004 • 41 citations

Stochastic Processes Influence Stationary-Phase Decisions in Bacillus subtilis

2004 • 41 citations

Epigenes: design and construction of new hereditary units

2000 • 40 citations

Evolution of cell lineage

1997 • 40 citations

p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress

2004 • 39 citations

Noise-reduction through interaction in gene expression and biochemical reaction processes

2004 • 39 citations

Noise, delays, robustness, canalization and all that

2004 • 38 citations

The Future is Noisy: The Role of Spatial Fluctuations in Genetic Switching

2001 • 38 citations

The initiation of hepatocyte-specific gene expression within embryonic hepatocytes is a stochastic event

1989 • 36 citations

Mechanistic Modeling of Prokaryotic mRNA Decay

1997 • 32 citations

Noise in gene expression as the source of non‐genetic individuality in the chemotactic response of Escherichia coli

2003 • 31 citations

How the mouse got its spots

2004 • 29 citations

The Future is Noisy

2001 • 28 citations

Polyribosomes and unstable messenger RNA: A stochastic model of protein synthesis

1969 • 26 citations

Fluctuating reaction rates and their application to problems of gene expression

2003 • 11 citations

Fluctuation of chromatin unfolding associated with variation in the level of gene expression

2004 • 11 citations