JNK-interacting Protein 1 Promotes Akt1 Activation

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Modulation of Akt kinase activity by binding to Hsp90

2000 • 942 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1

2001 • 700 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

2001 • 593 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

1999 • 454 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization

2002 • 348 citations

Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains

2000 • 330 citations

The Protooncogene TCL1 Is an Akt Kinase Coactivator

2000 • 327 citations

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

2000 • 300 citations

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

1996 • 278 citations

Structural Basis of 3-Phosphoinositide Recognition by Pleckstrin Homology Domains

2000 • 270 citations

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

2001 • 254 citations

Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase

2001 • 239 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

Akt1 Regulates a JNK Scaffold during Excitotoxic Apoptosis

2002 • 206 citations

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

2000 • 180 citations

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

1995 • 161 citations

PDK2: A Complex Tail in One Akt

2001 • 126 citations

Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1998 • 85 citations

Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells

1998 • 62 citations

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation

1998 • 48 citations

Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts

1996 • 22 citations

Analysis of the NF-κB and PI 3-Kinase/Akt Survival Pathways in Nerve Growth Factor-Dependent Neurons

2001 • 21 citations