Involvement of Cyclic GMP and Protein Kinase G in the Regulation of Apoptosis and Survival in Neural Cells
Data up to Jan 2025
Total Citations Per Year
Abstract
References (88)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
1987 • 10,774 citations
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
1996 • 5,498 citations
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
1987 • 5,027 citations
Glutamate, nitric oxide and cell-cell signalling in the nervous system
1991 • 2,406 citations
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 • 1,897 citations
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
1995 • 1,102 citations
Nitric Oxide: First in a New Class of Neurotransmitters
1992 • 1,001 citations
Nitric Oxide as a Signaling Molecule in the Vascular System: An Overview
1999 • 754 citations
Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.
1984 • 676 citations
Intracellular cyclic GMP receptor proteins
1993 • 655 citations
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
1994 • 428 citations
Neurons that say NO
1992 • 421 citations
The Utility of Superoxide Dismutase in Studying Free Radical Reactions
1970 • 389 citations
Chapter 15 Nitric oxide in neurodegeneration
1998 • 366 citations
Vasoactive Substances Regulate Vascular Smooth Muscle Cell Apoptosis
1996 • 345 citations
Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain.
1981 • 279 citations
Chapter 11 Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus
1998 • 271 citations
Endothelial dysfunction and atherosclerosis
1997 • 250 citations
Atrial Natriuretic Peptide Induces Apoptosis in Neonatal Rat Cardiac Myocytes
1997 • 237 citations
Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease
1977 • 232 citations
Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling
1999 • 225 citations
The Role of Cyclic Nucleotides in Central Synaptic Function
1975 • 177 citations
Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism
1996 • 171 citations
Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor
1998 • 170 citations
CREB and Its Associated Proteins Act as Survival Factors for Human Melanoma Cells
1998 • 163 citations
Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion.
1990 • 159 citations
Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain
1993 • 155 citations
Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion.
1992 • 149 citations
Anti-apoptotic Effect of cGMP in Cultured Astrocytes
2001 • 147 citations
Role of Cyclic GMP in the Regulation of Neuronal Calcium and Survival by Secreted Forms of β‐Amyloid Precursor
1995 • 142 citations
Molecular Characterization of a Type II Cyclic GMP‐Dependent Protein Kinase Expressed in the Rat Brain
1995 • 136 citations
Requirement for cGMP in Nerve Cell Death Caused by Glutathione Depletion
1997 • 135 citations
Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina.
1976 • 131 citations
cGMP-Dependent Protein Kinase in Dorsal Root Ganglion: Relationship with Nitric Oxide Synthase and Nociceptive Neurons
1996 • 125 citations
Chapter 1 Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways
1998 • 119 citations
Natriuretic Peptides and Nitric Oxide Induce Endothelial Apoptosis via a cGMP–Dependent Mechanism
1999 • 112 citations
Cyclic nucleotide gated channels as regulators of CNS development and plasticity
1997 • 110 citations
Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta
1985 • 110 citations
Evidence for the involvement of cGMP and protein kinase G in nitric oxide‐induced apoptosis in the pancreatic B‐cell line, HIT‐T15
1997 • 106 citations
Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function.
1996 • 105 citations
The Type II Isoform of cGMP-dependent Protein Kinase Is Dimeric and Possesses Regulatory and Catalytic Properties Distinct from the Type I Isoforms
1995 • 103 citations
cGMP: The wayward child of the cyclic nucleotide family
1991 • 103 citations
Guanosine 3′,5′-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission
1974 • 100 citations
Chapter 19 Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture
1998 • 92 citations
Cyclic GMP and cell death in rat cerebellar slices
1988 • 92 citations
Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
2001 • 86 citations
Molecular and pharmacological analysis of cyclic nucleotide-gated channel function in the central nervous system
1998 • 82 citations
Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta.
1983 • 80 citations
Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP‐dependent protein kinase
1999 • 80 citations
The Nitric Oxide‐Cyclic GMP Pathway Plays an Essential Role in Both Promoting Cell Survival of Cerebellar Granule Cells in Culture and Protecting the Cells Against Ethanol Neurotoxicity
1998 • 78 citations
Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis
1994 • 76 citations
Role of cyclic-GMP in Relaxations of Vascular mooth Muscle
1985 • 74 citations
Apoptosis, retinitis pigmentosa, and degeneration
1994 • 74 citations
Molecular mechanisms of endothelium-mediated vasodilation.
1988 • 71 citations
Cyclic guanosine 3′,5′-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurones
1997 • 68 citations
Natriuretic peptides inhibit apoptosis and prolong the survival of serum-deprived PC12 cells
2001 • 66 citations
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.
1991 • 65 citations
Calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor (EDRF)
1991 • 64 citations
Biology of ageing
1977 • 64 citations
Cyclic Nucleotide-Gated Channels Contribute to the Cholinergic Plateau Potential in Hippocampal CA1 Pyramidal Neurons
2001 • 63 citations
Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons
1999 • 61 citations
Effects of atriopeptin on particulate guanylate cyclase from rat adrenal
1985 • 57 citations
Cyclic Nucleotide‐Gated Channels: Molecular Mechanisms of Activation
1999 • 56 citations
Introduction to EDRF Research
1993 • 56 citations
Atrial Natriuretic Factors Stimulate Accumulation and Efflux of Cyclic GMP in C6–2B Rat Glioma and PC12 Rat Pheochromocytoma Cell Cultures
1987 • 54 citations
cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates Δ-CREB, and a synthetic Δ-CREB peptide
1992 • 47 citations
HIV‐1 Tat protein down‐regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3‐kinase/AKT/cyclic nucleoside phosphodiesterase pathway
2001 • 43 citations
[14] cGMP-dependent protein kinase activation in intact tissues
1988 • 40 citations
Neuroprotective effects of DETA-NONOate, a nitric oxide donor, on hydrogen peroxide-induced neurotoxicity in cortical neurones
1999 • 38 citations
Cyclic GMP-dependent protein kinase activation in canine tracheal smooth muscle by methacholine and sodium nitroprusside
1984 • 38 citations
Brain natriuretic peptide (BNP) causes endothelium-independent relaxation and elevation of cyclic GMP in rat thoracic aorta
1989 • 34 citations
Cyclic GMP‐Dependent Protein Kinase Substrates in Rat Brain
1995 • 31 citations
Neuronal regeneration, reorganization, and repair
1997 • 31 citations
Molecular Characterization and In Situ Localization Of A Full‐Length Cyclic Nucleotide‐Gated Channel In Rat Brain
1999 • 26 citations
Nω-Nitro-L-Arginine Blocks the Second Phase But Not the First Phase of the Endothelium-Dependent Relaxations Induced by Substance P in Isolated Rings of Pig Carotid Artery
1992 • 24 citations
Cyclic GMP-dependent protein phosphorylation in mammalian brain.
1983 • 24 citations
Nitroglycerin (exogenous nitric oxide) substitutes for endothelium-derived nitric oxide in potentiating vasorelaxations and cyclic AMP elevations induced by calcitonin gene-related peptide (CGRP) in rat aorta
1994 • 23 citations
Nitric Oxide in Brain Development, Plasticity, and Disease
1998 • 22 citations
Nitric oxide donors enhance calcitonin gene-related peptide-induced elevations of cyclic AMP in vascular smooth muscle cells
1999 • 18 citations
Mechanism of SNAP Potentiating Antiproliferative Effect of Calcitonin Gene-related Peptide in Cultured Vascular Smooth Muscle Cells
1999 • 18 citations
Mechanisms of neuronal degeneration: a final common pathway?
1997 • 15 citations
Severe impairment of CGRP-induced hypotension in vivo and vasorelaxation in vitro in elderly rats
2002 • 15 citations
Regulation of Cyclic GMP Synthesis and the Interactions with Calcium
1986 • 15 citations
QUANTIFICATION OF APOPTOTIC DNA FRAGMENTATION IN A TRANSFORMED UTERINE EPITHELIAL CELL LINE, HRE‐H9, USING CAPILLARY ELECTROPHORESIS WITH LASER‐INDUCED FLUORESCENCE DETECTOR (CE‐LIF)
2001 • 12 citations
Vasorelaxant response to isoprenaline, nitric oxide donor, calcitonin gene-related peptide and vasoactive intestinal peptide in aortic rings of adult C57BL/6J mice
2001 • 11 citations
Brain natriuretic peptide enhances the endothelium-independent cAMP and vasorelaxant responses of calcitonin gene-related peptide in rat aorta
1998 • 6 citations
The prevention of natural motoneuron cell death by dibutyryl-cyclic GMP in the spinal cord of White Leghorn chick embryos
1990 • 4 citations
Diabetes mellitus (DM) Causes Severe Impairment of Hypotensive Responses in vivo and Vasorelaxant Responses in vitro to the Neuropeptide CGRP
2001 • 2 citations