Endothelial dysfunction and atherosclerosis

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Endothelial dysfunction and vascular disease

2009 • 772 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Endothelium and control of vascular function. State of the Art lecture.

1989 • 661 citations

Modulation of Vascular Smooth Muscle Contraction by the Endothelium

1986 • 643 citations

The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress

1991 • 602 citations

Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test.

1988 • 564 citations

Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.

1982 • 545 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Endothelium-Dependent Hyperpolarization

1995 • 523 citations

Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress

1996 • 497 citations

Aging Progressively Impairs Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans

1996 • 471 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis

1994 • 457 citations

Endothelium-derived relaxing factor and coronary vasospasm.

1989 • 423 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

1989 • 421 citations

Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients

1991 • 420 citations

Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia

1996 • 411 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Endothelium-derived hyperpolarizing a new endogenous inhibitor from the vascular endothelium

1988 • 369 citations

Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.

1989 • 368 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium

1989 • 346 citations

Flow-dependent coronary artery dilatation in humans.

1989 • 333 citations

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

1987 • 303 citations

Large coronary arteries in humans are responsive to changing blood flow: An endothelium-dependent mechanism that fails in patients with atherosclerosis

1990 • 302 citations

Intracellular pH and Tyrosine Phosphorylation but Not Calcium Determine Shear Stress–Induced Nitric Oxide Production in Native Endothelial Cells

1996 • 287 citations

Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

1993 • 260 citations

THE VASCULAR BIOLOGY OF NITRIC OXIDE AND ITS ROLE IN ATHEROGENESIS

1996 • 256 citations

Physiology and pharmacology of endothelins

1992 • 239 citations

Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.

1993 • 233 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

1993 • 233 citations

Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.

1990 • 232 citations

Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

1992 • 230 citations

Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries.

1989 • 204 citations

Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries.

1991 • 195 citations

Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.

1989 • 185 citations

Endothelial and neuro-humoral control of coronary blood flow in health and disease

1990 • 174 citations

Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis.

1991 • 165 citations

Steady Shear and Step Changes in Shear Stimulate Endothelium via Independent Mechanisms—Superposition of Transient and Sustained Nitric Oxide Production

1996 • 165 citations

Endothelium-Derived Hyperpolarizing Factor

1990 • 152 citations

Endothelium-Dependent Responses in Hypertension.

1995 • 144 citations

The endothelium as a regulator of vascular smooth muscle proliferation

1993 • 141 citations

Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound

1996 • 130 citations

Endothelium-Derived Relaxing Factors and Converting Enzyme Inhibition

1995 • 129 citations

Endothelium-derived Hyperpolarizing Factor and Endothelium-dependent Relaxations

1993 • 126 citations

The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.

1993 • 126 citations

Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium‐dependent relaxation of pig isolated coronary artery

1994 • 120 citations

Molecular and cellular biology of endothelin and its receptors

1996 • 110 citations

Is endothelin involved in the pathogenesis of hypertension?

1993 • 105 citations

Endothelial Cell Signaling and Endothelial Dysfunction

1995 • 95 citations

Vascular reactivity during the progression of atherosclerotic plaque. A study in Watanabe heritable hyperlipidemic rabbits.

1990 • 93 citations

Other endothelium-derived vasoactive factors

1993 • 86 citations

Regulation of smooth muscle cell growth by endothelium-derived factors.

1994 • 80 citations

Flow‐induced prostacyclin production is mediated by a pertussis toxin‐sensitive G protein

1992 • 80 citations

Vasodilator and vasoconstrictor substances produced by the endothelium

1993 • 71 citations

Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo.

1993 • 66 citations

G Proteins and Endothelium-Dependent Relaxations

1997 • 58 citations

Nitric oxide synthases in vascular cells

1995 • 55 citations

ENDOTHELIAL LOSS AND REGENERATION IN A MODEL OF TRANSPLANT ARTERIOSCLEROSIS

1995 • 54 citations

Hypercholesterolaemia, atherosclerosis and release of endothelium-derived relaxing factor by aggregating platelets

1991 • 51 citations

Angiographic demonstration of hyperconstriction induced by serotonin and aggregating platelets in porcine coronary arteries with regenerated endothelium

1991 • 47 citations

Endothelin‐1: A Potent Vasoactive Peptide

1991 • 46 citations

The endothelium in health and disease.

1994 • 39 citations

Morphological heterogeneity with normal expression but altered function of G proteins in porcine cultured regenerated coronary endothelial cells

1997 • 38 citations

Endothelins

1993 • 37 citations

Gi proteins and the response to 5‐hydroxytryptamine in porcine cultured endothelial cells with impaired release of EDRF

1995 • 12 citations

Analysis of Pertussis Toxin-Sensitive Receptor: G-Protein Interactions in Native Porcine Endothelial Cells

1995 • 6 citations

Dysfunction of the Release of Endothelium-Derived Relaxing Factor

1992 • 5 citations

Deleted Work

1955 • 0 citations