A Point Mutation in the Extracellular Domain Activates LET-23, the Caenorhabditis elegans Epidermal Growth Factor Receptor Homolog

Molecular cloning: A laboratory manual

1990 • 85,659 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Current Protocols in Molecular Biology

2001 • 2,451 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

NONDISJUNCTION MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1979 • 768 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans

1980 • 567 citations

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

1985 • 531 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans

1981 • 494 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1980 • 413 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Pattern formation during vulval development in C. elegans

1986 • 411 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

A uniform genetic nomenclature for the nematode Caenorhabditis elegans

1979 • 382 citations

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

1990 • 375 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

1987 • 333 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant

1987 • 280 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.

1982 • 271 citations

Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans

1981 • 270 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans

1989 • 249 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

1988 • 242 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

1990 • 192 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

1991 • 170 citations

Activation of the feline c-fms proto-oncogene: Multiple alterations are required to generate a fully transformed phenotype

1988 • 164 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg

1992 • 154 citations

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

1990 • 150 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

1994 • 144 citations

CROSSOVER SUPPRESSORS AND BALANCED RECESSIVE LETHALS IN CAENORHABDITIS ELEGANS

1978 • 133 citations

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

1988 • 130 citations

Direct sequencing from low-melt agarose with Sequenase@

1989 • 122 citations

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

1995 • 107 citations

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

1994 • 102 citations

The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

1995 • 95 citations

Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.

1994 • 73 citations

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.

1990 • 71 citations

A Drosophila genomic sequence with homology to human epidermal growth factor receptor

1985 • 66 citations

The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans

1994 • 66 citations

The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.

1993 • 60 citations

NOVEL NEMATODE AMBER SUPPRESSORS

1985 • 53 citations

INTERCELLULAR SIGNALING AND SIGNAL TRANSDUCTION IN C. ELEGANS

1993 • 51 citations

Lethal and amanitin-resistance mutations in the Caenorhabditis elegans ama-1 and ama-2 genes.

1988 • 37 citations

Genetic control of Caenorhabditis elegans cell lineage.

1988 • 6 citations

Structural Basis of Oncogenic Activation of Epidermal Growth Factor Receptor

1994 • 2 citations

Deleted Work

1955 • 0 citations