Aromatase inhibitors in the treatment of breast cancer

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

Biochemical pharmacology of antiestrogen action.

1984 • 417 citations

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration.

1988 • 417 citations

Mechanism and inhibition of cytochrome P-450 aromatase

1990 • 316 citations

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

1988 • 302 citations

Studies on the Mechanism of Estrogen Biosynthesis. VIII. The Development of Inhibitors of the Enzyme System in Human Placenta1

1973 • 301 citations

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

1982 • 285 citations

Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma

1991 • 260 citations

Arimidex�: A potent and selective fourth-generation aromatase inhibitor

1994 • 258 citations

Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor

1990 • 243 citations

4-HYDROXYANDROSTENEDIONE IN TREATMENT OF POSTMENOPAUSAL PATIENTS WITH ADVANCED BREAST CANCER

1984 • 235 citations

Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route.

1987 • 234 citations

Human Aromatase: cDNA Cloning, Southern Blot Analysis, and Assignment of the Gene to Chromosome 15

1988 • 227 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4-hydroxyandrostenedione: phase II report.

1986 • 211 citations

Conversion of 19-hydroxy-Δ4-androstene-3,17-dione to estrone by endocrine tissue

1955 • 200 citations

6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitor

1988 • 148 citations

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

1981 • 141 citations

Tissue-specific promoters regulate aromatase cytochrome P450 expression

1993 • 134 citations

Suicide enzyme inhibitors as potential drugs

1981 • 119 citations

Studies on the mechanism of estrogen biosynthesis in the rat ovary–I

1976 • 113 citations

Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis

1991 • 113 citations

ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDR0STENE-3,6,17-TRI0NE AND 1,4,6-ANDR0STATRIENE-3,17-DI0NE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE ACTIVITY

1981 • 104 citations

Medical adrenalectomy using aminoglutethimide and dexamethasone in advanced breast cancer

1974 • 102 citations

Inhibition of Aromatase With CGS 16949A in Postmenopausal Women*

1989 • 99 citations

Peroxide model reaction for placental aromatase

1988 • 98 citations

Adrenal Suppression with Aminoglutethimide. II. Differential Effects of Aminoglutethimide on Plasma Androstenedione and Estrogen Levels¹²

1977 • 96 citations

Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives

1985 • 96 citations

Effects of Fadrozole (CGS 16949A) and Letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients

1994 • 95 citations

Is there a case for P-450 inhibitors in cancer treatment?

1989 • 88 citations

The efficacy of CGS 20267 in suppressing estrogen biosynthesis in patients with advanced stage breast cancer

1993 • 84 citations

Aromatase inhibition with 4-hydroxyandrostenedione in the treatment of postmenopausal patients with advanced breast cancer: a phase II study.

1990 • 83 citations

Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women.

1993 • 81 citations

4-Hydroxyandrostenedione treatment for postmenopausal patients with advanced breast cancer

1987 • 79 citations

1-methyl-1,4-androstadiene-3,17-dione (SH 489): Characterization of an irreversible inhibitor of estrogen biosynthesis

1986 • 77 citations

Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens. Implications for the structure of the active site.

1987 • 76 citations

Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects.

1993 • 73 citations

A site-directed mutagenesis study of human placental aromatase.

1992 • 72 citations

AN UPDATE ON ESTROGEN AND PROGESTERONE RECEPTORS IN PROGNOSIS FOR PRIMARY AND ADVANCED BREAST CANCER

1980 • 72 citations

A phase I trial of CGS 16949a. A new aromatase inhibitor

1990 • 68 citations

Mechanism of human placental aromatase: A new active site model

1993 • 67 citations

Mechanistic consideration of P-450 dependent enzymic reactions: studies on oestriol biosynthesis

1988 • 65 citations

New non-steroidal aromatase inhibitors: Focus on R76713

1990 • 57 citations

Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors

1993 • 56 citations

Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione

1990 • 54 citations

The intermediate steps in the biosynthesis of estrogens from androgens

1961 • 54 citations

Oral 4-hydroxyandrostenedione, a new endocrine treatment for disseminated breast cancer

1987 • 53 citations

Heterogeneity of progesterone receptor content and remodeling by tamoxifen characterize subpopulations of cultured human breast cancer cells: analysis by quantitative dual parameter flow cytometry.

1992 • 51 citations

The Mechanism of Estrogen Biosynthesis

1962 • 49 citations

7 α -Substituted androstenediones as effective in vttro and invivo inhibitors of aromatase

1987 • 46 citations

4-hydroxyandrostenedione – further clinical and extended endocrine observations

1990 • 41 citations

Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo

1982 • 40 citations

Comparison of the effects of the irreversible aromatase inhibitor exemestane with atamestane and MDL 18962 in rats with DMBA-induced mammary tumours

1991 • 38 citations

Estrogens and benign prostatic hyperplasia: The basis for aromatase inhibitor therapy

1987 • 36 citations

Potency and selectivity of the aromatase inhibitor R 76 713. A study in human ovarian, adipose stromal, testicular and adrenal cells

1990 • 31 citations

Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients

1991 • 31 citations

Inhibition of Peripheral Aromatization in Baboons by an Enzyme-Activated Aromatase Inhibitor (MDL 18,962)*

1988 • 28 citations

Aromatase Inhibitors III. Studies on the Antifertility Effect of 4-Acetoxy-4-androstene-3,17-dione1, 2, 3

1978 • 27 citations

Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4-diones

1991 • 24 citations

Biochemical and pharmacological development of steroidal inhibitors of aromatase

1990 • 23 citations

Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women

1993 • 23 citations

14.ALPHA.-Hydroxyandrost-4-ene-3,6,17-trione as a mechanical-based irreversible inhibitor of estrogen biosynthesis.

1990 • 21 citations

Open dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects

1993 • 20 citations

Steroidal inhibitors as chemical probes of the active site of aromatase

1993 • 18 citations

ORG 33201: A new highly selective orally active aromatase inhibitor

1993 • 11 citations

Human trophoblast xenografts in athymic mice: A model for peripheral aromatization

1989 • 10 citations

Randomized trial or the selective aromatase inhibitor formestane (Lentaron®) versus tamoxifen as first-line hormonal therapy in postmenopausal patients with advanced breast cancer

1993 • 4 citations

ChemInform Abstract: Synthesis and Aromatase Inhibitory Activity of Novel 1‐(4‐Aminophenyl)‐ 3‐azabicyclo(3.1.0)hexane‐ and ‐(3.1.1)heptane‐2,4‐diones.

1991 • 3 citations

Deleted Work

1955 • 0 citations