A site-directed mutagenesis study of human placental aromatase.

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.

1990 • 205 citations

Estrogen formation in the mammalian brain: Possible role of aromatase in sexual differentiation of the hippocampus and neocortex

1987 • 157 citations

in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione

1989 • 157 citations

Intratumoral aromatase as a prognostic factor in human breast carcinoma.

1989 • 105 citations

Aromatization of Δ-androstene-3,17-dione, 19-hydroxy-Δ4-androstene-3,17-dione, and 19-oxo-Δ-androstene-3,17-dione at a common catalytic site in human placental microsomes

1977 • 71 citations

Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg.

1991 • 49 citations

Aromatase activity in the breast and other peripheral tissues and its therapeutic regulation

1987 • 45 citations

Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of delta 6-testosterone from testosterone.

1990 • 41 citations

Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase

1991 • 34 citations