1-methyl-1,4-androstadiene-3,17-dione (SH 489): Characterization of an irreversible inhibitor of estrogen biosynthesis

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

1962 • 1,510 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization

1974 • 587 citations

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

1977 • 369 citations

SUICIDE SUBSTRATES, MECHANISM-BASED ENZYME INACTIVATORS: RECENT DEVELOPMENTS

1984 • 296 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

1981 • 141 citations

Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis

1978 • 112 citations

ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDR0STENE-3,6,17-TRI0NE AND 1,4,6-ANDR0STATRIENE-3,17-DI0NE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE ACTIVITY

1981 • 104 citations

Inhibition of Peripheral Aromatization of Androstenedione to Estrone in Postmenopausal Women with Breast Cancer Using Δ¹Testololactone*

1979 • 87 citations

Mechanism-based enzyme inactivators.

1984 • 83 citations

Aromatase inhibitors—iv. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione

1979 • 70 citations

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.

1982 • 67 citations

A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.

1982 • 50 citations

Multiple forms of aromatase and response of breast cancer aromatase to antiplacental aromatase II antibodies.

1982 • 41 citations

Basic studies on aminoglutethimide.

1982 • 31 citations