7 α -Substituted androstenediones as effective in vttro and invivo inhibitors of aromatase

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

Suicide substrates: mechanism-based enzyme inactivators

1982 • 443 citations

MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors

1975 • 430 citations

Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

1978 • 407 citations

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

1977 • 369 citations

Aminoglutethimide Inhibits Extraglandular Estrogen Production in Postmenopausal Women with Breast Carcinoma*

1978 • 345 citations

4-HYDROXYANDROSTENEDIONE IN TREATMENT OF POSTMENOPAUSAL PATIENTS WITH ADVANCED BREAST CANCER

1984 • 235 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

1982 • 212 citations

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

1981 • 141 citations

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

1981 • 127 citations

Suicide enzyme inhibitors as potential drugs

1981 • 119 citations

Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis

1978 • 112 citations

ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDR0STENE-3,6,17-TRI0NE AND 1,4,6-ANDR0STATRIENE-3,17-DI0NE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE ACTIVITY

1981 • 104 citations

Mechanism-based enzyme inactivators.

1984 • 83 citations

Biochemical and Endocrine Properties of a Mechanism-Based Inhibitor of Aromatase

1984 • 78 citations

Aromatase inhibitors—iv. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione

1979 • 70 citations

Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogs

1982 • 69 citations

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.

1982 • 67 citations

Synthesis and evaluation of 10β-substituted 4-estrene-3,17-diones as inhibitors of human placental microsomal aromatase

1982 • 65 citations

Estradiol Formation from Testosterone by Continuously Cultured Human Breast Cancer Cells*

1979 • 56 citations

Thiol-containing androgens as suicide substrates of aromatase

1985 • 54 citations

Potent enzyme-activated inhibition of aromatase by a 7 alpha-substituted C19 steroid.

1987 • 53 citations

Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo

1982 • 40 citations

7.alpha.-Substituted derivatives of androstenedione as inhibitors of estrogen biosynthesis

1985 • 40 citations

Effects of the aromatase inhibitor 7 alpha-(4'-amino)phenylthio-4-androstene-3,17-dione in MCF-7 human mammary carcinoma cell culture.

1987 • 30 citations

Comparative studies of aromatase inhibitors in cultured human breast cancer cells.

1982 • 21 citations

Covalent modification of aromatase by a radiolabeled irreversible inhibitor

1985 • 21 citations

ChemInform Abstract: 7α‐SUBSTITUTED DERIVATIVES OF ANDROSTENEDIONE AS INHIBITORS OF ESTROGEN BIOSYNTHESIS

1985 • 12 citations

A photoaffinity inhibitor of aromatase

1982 • 12 citations

Deleted Work

1955 • 0 citations