Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry

1983 • 407 citations

In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease

1996 • 374 citations

Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum

1983 • 359 citations

Neurobiological Bases of Age-Related Cognitive Decline in the Rhesus Monkey

1996 • 340 citations

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

1987 • 318 citations

Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles.

1996 • 294 citations

Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles

1996 • 283 citations

Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center

1988 • 238 citations

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

1991 • 234 citations

Age-related changes in multiple neurotransmitter systems in the monkey brain

1989 • 222 citations

Acetylcholine Transport, Storage, And Release

1993 • 202 citations

Molecular cloning of a putative vesicular transporter for acetylcholine.

1994 • 183 citations

Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.

1983 • 181 citations

Demonstration of a receptor in Torpedo synaptic vesicles for the acetylcholine storage blocker L-trans-2-(4-phenyl[3,4-3H]-piperidino) cyclohexanol.

1986 • 116 citations

In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM.

1994 • 114 citations

Acetylcholine release from rat cortical slices during postnatal development and aging

1983 • 109 citations

Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous systems of the rat

1994 • 107 citations

Cloning and expression of the vesamicol binding protein from the marine ray Torpedo

1994 • 105 citations

Kinetic Evaluation of [¹¹C]Dihydrotetrabenazine by Dynamic PET: Measurement of Vesicular Monoamine Transporter

1996 • 100 citations

Evidence that an ATPase and a protonmotive force function in the transport of acetylcholine into storage vesicles.

1980 • 97 citations

Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey

1992 • 96 citations

Studies on the blocking action of 2‐(4‐phenyl piperidino) cyclohexanol (AH5183)

1970 • 95 citations

Divergence of biological and chronological aging: Evidence from rodent studies

1991 • 81 citations

Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter

1995 • 80 citations

Regional concentrations of choline and acetylcholine in the rat brain

1974 • 80 citations

[³H]vesamicol binding in brain: Autoradiographic distribution, pharmacology, and effects of cholinergic lesions

1988 • 80 citations

Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging

1996 • 79 citations

Changes in Enzymes of the Cholinergic System and Acetylcholine Release in the Cerebra of Aging Male Fischer Rats

1983 • 73 citations

The Cholinergic System in Aging

1987 • 70 citations

Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker 2-(4-phenylpiperidino)cyclohexanol (AH5183).

1987 • 65 citations

The neuromuscular blocking action of 2-(4-phenylpiperidino) cyclohexanol (AH 5183)

1969 • 60 citations

Biochemical evidence that vesicles are the source of the acetylcholine released from stimulated PC12 cells.

1984 • 60 citations

In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats

1986 • 59 citations

Characterization and autoradiographic distribution of hemicholinium‐3 high‐affinity choline uptake sites in mammalian brain

1987 • 57 citations

p-[18F]fluorobenzyltrozamicol ([18F]FBT): Molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography

1994 • 51 citations

Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: In vitro binding studies and positron emission tomography studies in nonhuman primates

1997 • 48 citations

Central cholinergic functioning and aging

1991 • 43 citations

Neurotransmitters in neocortex of aged rhesus monkeys

1991 • 43 citations

Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey

1990 • 43 citations

The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: Model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents

1993 • 41 citations

Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey

1993 • 41 citations

REGIONAL AND SUBCELLULAR DISTRIBUTION AND KINETIC PROPERTIES OF RAT BRAIN CHOLINE ACETYLTRANSFERASE–SOME FUNCTIONAL CONSIDERATIONS

1975 • 41 citations

Striatal D2/acetylcholine interactions

1993 • 34 citations

Comparison of neutral proteinase activities in cock and ram spermatozoa and observations on a proacrosin in cock spermatozoa

1976 • 23 citations

Age-dependent decrease in the affinity of muscarinic M1 receptors in neocortex of rhesus monkeys.

1991 • 20 citations

Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population

1993 • 8 citations

Age-related behavioral and neurochemical deficits: The cholinergic system revisited

1993 • 6 citations

Comparative tissue distribution of conformationally restricted radioiodinated vesamicol receptor ligands

1995 • 6 citations

Changes in cholinergic receptor subtypes in behaviorally-tested, aged monkeys

1993 • 5 citations

Age-related changes in monkey and rodent neurochemistry

1993 • 3 citations