Central cholinergic functioning and aging

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Neurobiology of Mood Disorders

1985 • 492 citations

The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system

1987 • 318 citations

Brain cholinergic dysfunction and memory in aged rats

1980 • 257 citations

Neurochemical Correlates of Major Depression in Primary Dementia

1990 • 233 citations

Stage‐specific behavioral, cognitive, and in vivo changes in community residing subjects with age‐associated memory impairment and primary degenerative dementia of the Alzheimer type

1988 • 173 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Receptor alterations and drug tolerance

1979 • 117 citations

The risk factors for Alzheimer's disease: a review and a hypothesis

1988 • 111 citations

Aging and brain cholinergic muscarinic receptor subtypes: An autoradiographic study in the rat

1989 • 90 citations

Effects of aging on rat cortical presynaptic cholinergic processes

1984 • 85 citations

Cholinergic receptors in aging and Alzheimer's disease

1986 • 71 citations

Changes in neurotransmitter actions in the aged rat hippocampus

1982 • 70 citations

Reduced muscarinic receptor plasticity in frontal cortex of aged rats after chronic administration of cholinergic drugs

1985 • 54 citations

Aging does not alter brain muscarinic receptor-mediated phosphoinositide hydrolysis and its inhibition by phorbol esters, tetrodotoxin and receptor desensitization.

1989 • 51 citations

Age-related deficits of central muscarinic cholinergic receptor function in the mouse: Partial restoration by chronic piracetam treatment

1992 • 51 citations

Acetylcholine, aging and anatomy: differential effects in the hippocampus

1986 • 42 citations

Muscarinic receptor plasticity in the brain of senescent rats: Down-regulation after repeated administration of diisopropyl fluorophosphate

1988 • 41 citations

Psychische Gesundheit im Alter

2013 • 40 citations

Multiple changes in the sensitivity of cingulate cortical neurones to putative neurotransmitters in ageing rats: Substance P, acetylcholine and noradrenaline

1984 • 35 citations

Changes in receptor stimulated phosphoinositide hydrolysis in brain during ethanol administration, aging, and other pathological conditions.

1986 • 32 citations

Age‐associated memory impairment: The clinical syndrome

1986 • 30 citations

Effect of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors

1988 • 26 citations

The Origins of Depression: Current Concepts and Approaches

1984 • 26 citations

Cerebral neocortical neurons in the aged rat: Spontaneous activity, properties of pyramidal tract neurons and effect of acetylcholine and cholinergic drugs

1985 • 24 citations

Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice

1988 • 24 citations

Psychopharmacology of Old Age

1983 • 19 citations

Plasticity of brain muscarinic receptors in aging rats: The adaptative response to scopolamine and ethanol treatment

1989 • 16 citations

Pharmacological adaptations and muscarinic receptor plasticity in hypothalamus of senescent rats treated chronically with cholinergic drugs

1988 • 14 citations

Muscarinic receptor plasticity in rats lesioned in the nucleus basalis of Meynert

1989 • 12 citations

Acetylcholine and brain aging

1988 • 10 citations

The Cholinergic System in Aging

1988 • 9 citations

The Epidemiology of Bipolar and Nonbipolar Depression: Rates and Risks

1983 • 4 citations

Muscarinic Acetylcholine Receptor-Linked Inositide Cycle in the Central Nervous System

1987 • 3 citations