The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: Model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

A Ciba Foundation Symposium

1972 • 562 citations

Forty years of hydride reductions

1979 • 435 citations

The preparation of 11C-methyl iodide and its use in the synthesis of 11C-methyl-L-methionine

1976 • 197 citations

Aryltrimethylammonium trifluoromethanesulfonates as precursors to aryl [¹⁸F]fluorides: Improved synthesis of [¹⁸F]GBR‐13119

1989 • 177 citations

Lipophilicity measurements of protonated basic compounds by reversed-phase high-performance liquid chromatography

1985 • 115 citations

A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting radionuclide fluorine-18

1987 • 114 citations

Lipophilicity measurements of protonated basic compounds by reversed-phase high-performance liquid chromatography

1985 • 105 citations

High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides.

1991 • 85 citations

Syntheses and specific activity determinations of no-carrier-added (NCA) F-18-labeled butyrophenone neuroleptics--benperidol, haloperidol, spiroperidol, and pipamperone.

1985 • 79 citations

No-carrier-added (NCA) aryl [18F]fluorides via the nucleophilic aromatic substitution of electron-rich aromatic rings

1990 • 73 citations

Serotonergic component of SCH 23390: In vitro and in vivo binding analyses

1988 • 73 citations

Synthesis of high specific activity (+)- and (-)-6-[18F]fluoronorepinephrine via the nucleophilic aromatic substitution reaction

1991 • 65 citations

No-carrier-added fluorine-18-labeled N-methylspiroperidol: synthesis and biodistribution in mice.

1986 • 61 citations

Synthesis of high specific activity 6-[18F]fluorodopamine for positron emission tomography studies of sympathetic nervous tissue

1991 • 60 citations

Comparison of the In-vitro Receptor Selectivity of Substituted Benzamide Drugs for Brain Neurotransmitter Receptors

1988 • 58 citations

Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives

1986 • 56 citations

A new route for the synthesis of [18F]fluoroaromatic substituted amino acids: No carrier added fluorophenylalanine

1987 • 55 citations

Reductive amination of [¹⁸F]fluorobenzaldehydes: Radiosyntheses of [2‐¹⁸F]‐ and [4‐¹⁸F]fluorodexetimides

1990 • 53 citations

Displacement of a nitro-group by [¹⁸F] fluoride ion. A new route to aryl flurides of high specific activity

1983 • 53 citations

Production of reactive fluorine-18

1986 • 47 citations

N-(3-[18F]fluoropropyl)-spiperone: The preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

1988 • 46 citations

Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides

1977 • 44 citations

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors

1991 • 42 citations

Assessment of dopamine receptor densities in the human brain with carbon-11-labeled N-methylspiperone

1984 • 42 citations

N 3 fluorine 18 fluoropropylspiperone the preferred fluorine 18 labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

1988 • 41 citations

Relative activities of SCH 23390 and its analogs in three tests for D1/DA1 dopamine receptor antagonism

1986 • 37 citations

Investigation on central dopaminergic receptors (D-2) using the antagonistic properties of new benzamides

1984 • 36 citations

An approach to the asymmetric synthesis of l-6-[18F]fluorodopa via NCA nucleophilic fluorination

1991 • 33 citations

Potent lipophilic substituted benzamide drugs are not selective D-1 dopamine receptor antagonists in the rat

1983 • 32 citations

Multiple fluorescent ligands for dopamine receptors. I. Pharmacological characterization and receptor selectivity

1991 • 32 citations

In vivo labeling of the dopamine D2 receptor with N-11C-methyl-benperidol.

1990 • 31 citations

Labelling of fluorinated aromatics by isotopic exchange with [¹⁸F]fluoride

1981 • 30 citations

(.+-.)-7-Chloro-8-hydroxy-1-(4'-[125I]iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine: a potential CNS D-1 dopamine receptor imaging agent

1989 • 27 citations

Effect of N-alkylation on the affinities of analogs of spiperone for dopamine D2 and serotonin 5-HT2 receptors

1992 • 27 citations

Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

1990 • 27 citations

Radiochemical synthesis of [18F]fluororaclopride

1989 • 24 citations

The synthesis of o‐ and p‐[¹⁸F]fluorobenzyl bromides and their application to the prepatation of labeled neuroleptics

1991 • 24 citations

N-Fluoroalkylated and N-alkylated analogs of the dopaminergic D-2 receptor antagonist raclopride

1990 • 23 citations

Positron labeled muscarinic acetylcholine receptor antagonist: 2- and 4-[18F]fluorodexetimide. Syntheses and biodistribution

1991 • 22 citations

Serotonin-2 receptors coupled to phosphoinositide hydrolysis in a clonal cell line.

1990 • 21 citations

Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines

1990 • 16 citations

Characterization of [125I]SCH 23982 binding in human brain: Comparison with [3H]SCH 23390

1991 • 14 citations

Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors

1990 • 13 citations

Sex-dependent differences in N-(3-[18F]fluoropropyl)-N-nordiprenorphine biodistribution and metabolism.

1990 • 13 citations

Drug Metabolite Isolation and Determination

1983 • 13 citations

Preparation and biological evaluation of 18F-labeled benzamide analogs as potential dopamine D2 receptor ligands

1990 • 12 citations

Imaging the Serotonergic System by Positron Emission Tomography

1990 • 12 citations

[125I](±)FISCH: A new CNS D-1 dopamine receptor imaging ligand

1989 • 10 citations

Synthesis and in vivo evaluation of [18F]-N-(p-Nitrobenzyl)spiperone ([18F]PNBS) in rats

1993 • 5 citations

A CONVENIENT SYNTHESIS OF METHYL 4-AMINO-5-CHLORO-2-MTHOXYBENZOATE

1992 • 4 citations