Effects of Tissue Type Plasminogen Activator in Embolic versus Mechanical Models of Focal Cerebral Ischemia in Rats

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Intracerebral Hemorrhage After Intravenous t-PA Therapy for Ischemic Stroke

1997 • 827 citations

Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats.

1993 • 706 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1998 • 629 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

1999 • 548 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

1997 • 421 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1995 • 346 citations

Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

1992 • 309 citations

Hemorrhagic Transformation and Microvascular Integrity during Focal Cerebral Ischemia/Reperfusion

1996 • 291 citations

Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro

1981 • 231 citations

Microvascular changes during cerebral ischemia and reperfusion.

1994 • 194 citations

An animal model of cerebral infarction. Homologous blood clot emboli in rats.

1982 • 162 citations

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

1997 • 126 citations

Inhibition of Poly(ADP-Ribose) Polymerase

1998 • 125 citations

DNA Scission After Focal Brain Ischemia

1997 • 107 citations

Temporal Correlation Mapping Analysis of the Hemodynamic Penumbra in Mutant Mice Deficient in Endothelial Nitric Oxide Synthase Gene Expression

1996 • 103 citations

Reperfusion after Thrombolytic Therapy of Embolic Stroke in the Rat: Magnetic Resonance and Biochemical Imaging

1998 • 101 citations

Diffusion-, T₂-, and Perfusion-Weighted Nuclear Magnetic Resonance Imaging of Middle Cerebral Artery Embolic Stroke and Recombinant Tissue Plasminogen Activator Intervention in the Rat

1998 • 97 citations

Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion

1995 • 76 citations

Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures

1999 • 57 citations

YM872, a Highly Water-Soluble AMPA Receptor Antagonist, Preserves the Hemodynamic Penumbra and Reduces Brain Injury After Permanent Focal Ischemia in Rats

1998 • 48 citations