Diffusion-, T₂-, and Perfusion-Weighted Nuclear Magnetic Resonance Imaging of Middle Cerebral Artery Embolic Stroke and Recombinant Tissue Plasminogen Activator Intervention in the Rat

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders.

1986 • 3,711 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy

1990 • 1,629 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Magnetic resonance imaging of perfusion using spin inversion of arterial water.

1992 • 1,497 citations

The Harvard Cooperative Stroke Registry

1978 • 1,180 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

What is the Correct Value for the Brain-Blood Partition Coefficient for Water?

1985 • 693 citations

Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.

1992 • 515 citations

Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia.

1989 • 488 citations

Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat.

1993 • 484 citations

Functional recovery of cortical neurons as related to degree and duration of ischemia

1983 • 396 citations

Tissue Plasminogen Activator Reduces Neurological Damage After Cerebral Embolism

1985 • 369 citations

Rapid NMR imaging of dynamic processes using the FLASII technique

1986 • 369 citations

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

1994 • 360 citations

Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats.

1992 • 326 citations

A rat model of focal embolic cerebral ischemia

1997 • 324 citations

Diffusion-weighted imaging studies of cerebral ischemia in gerbils. Potential relevance to energy failure.

1992 • 317 citations

Transient diffusion in a system partitioned by permeable barriers. Application to NMR measurements with a pulsed field gradient

1978 • 291 citations

Oxygen Radicals in Focal Cerebral Ischemia

1994 • 263 citations

Diffusion-Weighted Magnetic Resonance Imaging of Acute Focal Cerebral Ischemia: Comparison of Signal Intensity with Changes in Brain Water and Na⁺,K⁺-ATPase Activity

1994 • 212 citations

Restoration of Middle Cerebral Artery Flow in Experimental Infarction

1969 • 212 citations

Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging.

1991 • 206 citations

Microvascular changes during cerebral ischemia and reperfusion.

1994 • 194 citations

Temporary Occlusion of the Middle Cerebral Artery in the Monkey: Clinical and Pathological Observations

1970 • 191 citations

A New Rat Model of Thrombotic Focal Cerebral Ischemia

1997 • 184 citations

Restricted Diffusion in Biophysical Systems

1974 • 184 citations

Neutrophil inhibitory factor is neuroprotective after focal Ischemia in rats

1995 • 150 citations

The effect of the NMDA receptor antagonist MK-801 on cerebral blood flow and infarct volume in experimental focal stroke

1992 • 142 citations

Tissue Plasminogen Activator

1988 • 139 citations

Restricted and anisotropic displacement of water in healthy cat brain and in stroke studied by NMR diffusion imaging

1991 • 132 citations

Eigenimage Filtering in MR Imaging

1988 • 130 citations

Experimental Cerebral Venous Thrombosis: Evaluation Using Magnetic Resonance Imaging

1996 • 128 citations

Cerebral Ischemia and Reactive Hyperemia

1971 • 127 citations

Sequential neuronal and astrocytic changes after transient middle cerebral artery occlusion in the rat

1993 • 124 citations

A Rat Model of Reproducible Cerebral Infarction Using Thrombotic Blood Clot Emboli

1992 • 115 citations

A “radical” view of cerebral ischemic injury

1994 • 114 citations

The beneficial effect of intracarotid urokinase on acute stroke in a baboon model.

1986 • 105 citations

OCCLUSION OF THE MIDDLE CEREBRAL ARTERY AND ITS BRANCHES: ANGIOGRAPHIC AND CLINICAL CORRELATES

1969 • 102 citations

Transient embolic occlusion of the middle cerebral and internal carotid arteries in cerebral apoplexy.

1969 • 100 citations

Neurological deficit and cerebral infarction after temporary middle cerebral artery occlusion in unanesthetized cats.

1986 • 99 citations

Recombinant human tissue-type plasminogen activator therapy in acute thromboembolic stroke

1987 • 96 citations

Barbiturate coma in focal cerebral ischemia

1982 • 92 citations

The temporal evolution of MRI tissue signatures after transient middle cerebral artery occlusion in rat

1997 • 91 citations

Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion

1993 • 81 citations

Pharmacologic Reversal of Acute Changes in Diffusion-Weighted Magnetic Resonance Imaging in Focal Cerebral Ischemia

1994 • 81 citations

The Effect of Hypothermia on Transient Focal Ischemia in Rat Brain Evaluated by Diffusion- and Perfusion-Weighted NMR Imaging

1994 • 75 citations

Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 2: Effects on brain water and electrolytes in the early phase of MCA stroke.

1977 • 68 citations

Neuroprotection With NBQX in Rat Focal Cerebral Ischemia

1997 • 52 citations

Failure of naloxone to affect focal incomplete cerebral ischemia and collateral blood flow in cats

1983 • 49 citations

The Effect of Dexamethasone on the Edema of Focal Cerebral Ischemia

1973 • 48 citations

Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model

1993 • 46 citations

The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model

1988 • 43 citations

Contribution of intravoxel incoherent motion (IVIM) imaging to neuroradiology.

1987 • 37 citations

Reduction of infarct volume by thrombolysis with rt-PA in an embolic rat stroke model

1993 • 35 citations

Improved Perfusion with rt-PA and Hirulog in a Rabbit Model of Embolic Stroke

1997 • 35 citations

PROTECTION OF THE BRAIN FROM ISCHEMIA

1991 • 31 citations

A comparison of intra-arterial and intravenous tissue-type plasminogen activator on autologous arterial emboli in the cerebral circulation of rabbits.

1994 • 28 citations

Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke

1993 • 27 citations

Analysis of the evolution of focal cerebral ischemia in the rat using the eigenimage filter

1992 • 25 citations

ISCHAEMIC BRAIN

1985 • 25 citations

Sanguineous cerebrospinal fluid in recanalized cerebral infarction.

1977 • 23 citations

The effect of intravenous tissue-type plasminogen activator in a rat model of embolic cerebral ischemia.

1987 • 18 citations

The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia.

1994 • 13 citations