Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

Mitochondria and Apoptosis

1998 • 8,909 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Bcl-2 family proteins

1998 • 1,055 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

1999 • 485 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

Mitochondria and Apoptosis

1999 • 273 citations

Bak BH3 Peptides Antagonize Bcl-xL Function and Induce Apoptosis through Cytochrome c-independent Activation of Caspases

1999 • 255 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Heterodimerization-independent Functions of Cell Death Regulatory Proteins Bax and Bcl-2 in Yeast and Mammalian Cells

1997 • 171 citations

Crystal Structure of Rat Bcl-xL

1997 • 121 citations

The Binding Properties and Biological Activities of Bcl-2 and Bax in Cells Exposed to Apoptotic Stimuli

1998 • 89 citations

Anti-apoptotic genes of baculoviruses.

1996 • 88 citations

The BH3 Domain of Bax is Sufficient for Interaction of Bax with itself and with other Family Members and it is Required for Induction of Apoptosis

1997 • 56 citations

Bax Homodimerization Is Not Required for Bax to Accelerate Chemotherapy-induced Cell Death

1996 • 49 citations

Dissection of functional domains in Bcl-2α by site-directed mutagenesis

1994 • 31 citations

Purification and Biochemical Properties of Soluble Recombinant Human Bax

1998 • 27 citations

Bcl-2 does not require Raf kinase activity for its death-protective function

1997 • 22 citations