Development of an Immune System^a

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Wonderful life: the Burgess Shale and the nature of history

1990 • 3,022 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Two distinct classes of carbohydrate-recognition domains in animal lectins.

1988 • 1,259 citations

Vertebrate Paleontology

1967 • 1,207 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

1955 • 700 citations

Autoimmunity, microbial immunity and the immunological homunculus

1991 • 525 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Growth Cone Guidance in Insects: Fasciclin II Is a Member of the Immunoglobulin Superfamily

1988 • 424 citations

Agnathans and the origin of jawed vertebrates

1993 • 384 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

“Self-recognition” in Colonial Marine Forms and Flowering Plants in relation to the Evolution of Immunity

1971 • 288 citations

Vertebrate blood cells

1988 • 282 citations

The Immune System of Xenopus

1989 • 261 citations

Immunity in infective diseases

1905 • 252 citations

Hemolin: an Insect-Immune Protein Belonging to the Immunoglobulin Superfamily

1990 • 247 citations

Avian B-Cell Development: Generation of an Immunoglobulin Repertoire by Gene Conversion

1991 • 236 citations

Gene Activity in Early Development

1970 • 236 citations

Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution

1986 • 223 citations

PHYLOGENETIC ORIGINS OF ANTIBODY STRUCTURE

1965 • 204 citations

THE EVOLUTION OF THE IMMUNE RESPONSE

1964 • 190 citations

Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain.

1992 • 188 citations

CAMs and Igs: Cell Adhesion and the Evolutionary Origins of Immunity

1987 • 187 citations

Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution.

1985 • 182 citations

Sharks of the order Carcharhiniformes

1988 • 180 citations

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1988 • 177 citations

PHYLOGENETIC ORIGINS OF ANTIBODY STRUCTURE

1968 • 174 citations

The complete amino acid sequence of echinoidin, a lectin from the coelomic fluid of the sea urchin Anthocidaris crassispina. Homologies with mammalian and insect lectins.

1987 • 168 citations

Characterization of amalgam: A member of the immunoglobulin superfamily from Drosophila

1988 • 164 citations

Fish immunoglobulins and the genes that encode them

1992 • 162 citations

IgG autoantibody activity in normal mouse serum is controlled by IgM.

1990 • 154 citations

Evolution of the major histocompatibility complex: isolation of class II A cDNA clones from the cartilaginous fish.

1992 • 133 citations

Expression and control of the natural autoreactive IgG repertoire in normal human serum

1993 • 129 citations

Complete amino acid sequence of a membrane receptor for glycoproteins. Sequence of the chicken hepatic lectin.

1981 • 125 citations

Immunity in evolution

1977 • 122 citations

Are Invertebrates Capable of Anticipatory Immune Responses?

1989 • 120 citations

Isolation of a hagfish gene that encodes a complement component.

1992 • 119 citations

Complete complementary DNA sequence of the third component of complement of lamprey. Implication for the evolution of thioester containing proteins.

1992 • 116 citations

Specificity of natural serum antibodies present in phylogenetically distinct fish species.

1988 • 107 citations

The echinoid immune system and the phylogenetic occurrence of immune mechanisms in deuterostomes

1992 • 101 citations

SPECIFIC ALLOGRAFT REACTIVITY IN THE SEA STAR Dermasterias imbricata

1976 • 92 citations

Genomic organization and sequences of immunoglobulin light chain genes in a primitive vertebrate suggest coevolution of immunoglobulin gene organization.

1989 • 91 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

The amino acid sequence of Limulus C-reactive protein. Evidence of polymorphism.

1986 • 77 citations

Some new concepts in immunological phylogeny

1974 • 76 citations

Immunity in Invertebrates

1986 • 71 citations

The MHC Molecules of Nonmammalian Vertebrates

1990 • 70 citations

Immunoglobulins did not arise in evolution to fight infection

1992 • 69 citations

Lack of heterogeneity in anti-hapten antibodies of a phylogenetically primitive shark

1980 • 69 citations

The Big Bang of Animal Evolution

1992 • 66 citations

Complete sequence of a cDNA clone specifying sandbar shark immunoglobulin light chain: gene organization and implications for the evolution of light chains.

1992 • 62 citations

Galactosyl-binding lectins from the tunicate Didemnum candidum. Purification and physicochemical characterization.

1986 • 59 citations

Origin and Diversification of Anti‐DNA Antibodies

1988 • 58 citations

Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements.

1985 • 57 citations

Allograft rejection and alloimmune memory in the solitary urochordate, Styelaplicata

1987 • 54 citations

Antibody production in sharks and humans: A role for natural antibodies

1993 • 51 citations

Ionic regulation in fish: The influence of acclimation temperature on plasma composition and apparent set points

1986 • 49 citations

Humoral Immunity in Insects

1990 • 49 citations

Origins of Immunoglobulins and Immune Recognition Molecules

1990 • 46 citations

Galactosyl-binding lectins from the tunicate Didemnum candidum. Carbohydrate specificity and characterization of the combining site.

1986 • 46 citations

Characterization of immunoglobulin from the Pacific hagfish, a primitive vertebrate

1978 • 45 citations

Invertebrate recognition protein cross-reacts with an immunoglobulin idiotype.

1984 • 42 citations

Genes encoding Xenopus laevis Ig L chains. Implications for the evolution of kappa and lambda chains.

1992 • 40 citations

A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin.

1991 • 40 citations

Evolution of immunoglobulin light chains: cDNA clones specifying sandbar shark constant regions.

1989 • 40 citations

Evolution of variable and constant domains and joining segments of rearranging immunoglobulins

1989 • 38 citations

Electron microscopy of the leucocytes of the typhlosole in ammocoetes, with special attention to the antibody- producing cells

1982 • 38 citations

Tunicate lectins: distribution and specificity

1982 • 32 citations

Comprehensive Immunogenetics

1981 • 31 citations

Isolation and characterization of immunoglobulin of hagfish, Eptatretus burgeri, a primitive vertebrate

1985 • 25 citations

Reactivity of anti-human C-reactive protein (CRP) and serum amyloid P component (SAP) monoclonal antibodies with limulin and pentraxins of other species.

1992 • 24 citations

Conservation among vertebrate immunoglobulin chains detected by antibodies to a synthetic joining segment peptide

1987 • 24 citations

Phylogeny of immunoglobulin structure and function—VIII

1980 • 24 citations

Antigenic cross-reactions among immunoglobulin of diverse vertebrates (elasmobranchs to man) detected using xenoantisera

1992 • 22 citations

The immune response in adult sea lamprey (Petromyzon marinus L.): The effect of temperature

1985 • 17 citations

Isolation and characterization of agglutinins from the hemolymph of an acorn barnacle, Megabalanusvolcano

1987 • 14 citations

Monoclonal anti‐V_H antibodies recognize a common V_H determinant expressed on immunoglobulin heavy chains from various species

1983 • 14 citations

Partial characterization of immunoglobulin light chains of carcharhine sharks: Evidence for phylogenetic conservation of variable region and divergence of constant region structure

1988 • 14 citations

Four billion years: An essay on the evolution of genes and organisms

1989 • 13 citations

Brain temperature regulation of panting and non-panting pigeons exposed to extreme thermal conditions

1989 • 11 citations

Shark lymphocytes: Primitive antigen reactive cells

1992 • 9 citations

Shared antigenic determinants of immunoglobulins in phylogeny and in comparison with T-cell receptors

1993 • 9 citations

Evolutionary Development of the B‐Cell Repertoire^a

1992 • 8 citations

CD3- T cells with cis- or trans-acting mutations affecting expression of T cell receptor beta-chain mRNA.

1992 • 3 citations