Intracellular adapter molecules

Inositol phosphates and cell signalling

1989 • 4,058 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

LAT

1998 • 1,251 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

BLNK

1998 • 501 citations

A novel receptor involved in T-cell activation

1995 • 487 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

The complexity of signaling pathways activated by the BCR

1997 • 333 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

1999 • 313 citations

Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP

1999 • 308 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

1999 • 291 citations

Structure and function of the WW domain

1996 • 290 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.

1994 • 246 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.

1993 • 237 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Interactions of Cbl with Grb2 and Phosphatidylinositol 3′-Kinase in Activated Jurkat Cells

1995 • 217 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

Isolation and chromosomal localization of CRKL, a human crk-like gene.

1993 • 203 citations

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells

1996 • 201 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

SH2 domain specificity and activity modified by a single residue

1994 • 188 citations

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1995 • 184 citations

Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G

1996 • 181 citations

Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.

1991 • 180 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

Soluble and Membrane-bound Forms of Signaling Lymphocytic Activation Molecule (SLAM) Induce Proliferation and Ig Synthesis by Activated Human B Lymphocytes

1997 • 179 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase

1996 • 170 citations

Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production.

1997 • 168 citations

Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase

1998 • 167 citations

p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

1993 • 167 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

1999 • 147 citations

BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius.

1998 • 146 citations

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.

1993 • 134 citations

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

1998 • 131 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

1996 • 129 citations

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex.

1991 • 129 citations

Differential Requirements for ZAP-70 in TCR Signaling and T Cell Development

1998 • 122 citations

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation

1999 • 121 citations

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

1998 • 114 citations

Grap Is a Novel SH3-SH2-SH3 Adaptor Protein That Couples Tyrosine Kinases to the Ras Pathway

1996 • 114 citations

Tyrosine Phosphorylation of SLP-76 Is Downstream of Syk following Stimulation of the Collagen Receptor in Platelets

1999 • 110 citations

The Role of a Lymphoid-restricted, Grb2-like SH3-SH2-SH3 Protein in T Cell Receptor Signaling

1997 • 109 citations

Cutting Edge: BASH, A Novel Signaling Molecule Preferentially Expressed in B Cells of the Bursa of Fabricius

1998 • 109 citations

Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.

1996 • 108 citations

Towards prediction of cognate complexes between the WW domain and proline‐rich ligands

1996 • 108 citations

Enhancement of Guanine-Nucleotide Exchange Activity of C3G for Rap1 by the Expression of Crk, CrkL, and Grb2

1997 • 105 citations

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1994 • 104 citations

Protein Kinase C μ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins

1999 • 103 citations

Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 in Human T-lymphocytes

1997 • 102 citations

Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes

1999 • 98 citations

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

1999 • 98 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

1998 • 95 citations

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase

1996 • 95 citations

Three domains of SLP-76 are required for its optimal function in a T cell line.

1997 • 87 citations

A Comparison of the Interaction of Shc and the Tyrosine Kinase ZAP-70 with the T Cell Antigen Receptor ζ Chain Tyrosine-based Activation Motif

1995 • 86 citations

SKAP‐HOM, a novel adaptor protein homologous to the FYN‐associated protein SKAP55¹

1998 • 85 citations

Insulin Stimulation of a MEK-Dependent but ERK-Independent SOS Protein Kinase

1996 • 82 citations

Interaction of p59fyn Kinase with the Dynein Light Chain, Tctex-1, and Colocalization During Cytokinesis

1998 • 79 citations

SLP-76 Expression Is Restricted to Hemopoietic Cells of Monocyte, Granulocyte, and T Lymphocyte Lineage and Is Regulated During T Cell Maturation and Activation

1998 • 75 citations

SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity

1999 • 70 citations

Tyrosine-phosphorylated Cbl binds to Crk after T cell activation.

1996 • 60 citations

Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.

1995 • 52 citations

Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells.

1997 • 45 citations

NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein

1999 • 43 citations

Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor.

1996 • 39 citations

Characterization of protein kinase C and its isoforms in human T lymphocytes.

1988 • 38 citations

Molecular Cloning and Expression of HumanGrap-2, a Novel Leukocyte-Specific SH2- and SH3-Containing Adaptor-like Protein That Binds toGab-1

1998 • 32 citations