Overview of matrix metalloproteinase expression in cultured human cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.

1996 • 3,063 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

1995 • 1,489 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis

1994 • 333 citations

Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells.

1992 • 329 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

The collagen substrate specificity of human neutrophil collagenase.

1987 • 285 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

1994 • 243 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.

1992 • 228 citations

Association of MMP-2 Activation Potential With Metastatic Progression in Human Breast Cancer Cell Lines Independent of MMP-2 Production

1993 • 216 citations

Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members

1989 • 212 citations

Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.

1992 • 206 citations

Regulation of Membrane‐Type Matrix Metalloproteinase‐1 Expression by Growth Factors and Phorbol 12‐Myristate 13‐Acetate

1996 • 184 citations

A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI

1994 • 183 citations

The origin of matrix metalloproteinases and their familial relationships

1991 • 182 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

Matrix Metalloproteinase Matrilysin Is Constitutively Expressed in Adult Human Exocrine Epithelium

1995 • 174 citations

The Frequency of Immortalization of Human Fibroblasts and Mammary Epithelial Cells Transfected with SV40 Large T-Antigen

1993 • 165 citations

Resistance of Malignant Trophoblast Cells to both the Anti-proliferative and Anti-invasive Effects of Transforming Growth Factor-β

1994 • 164 citations

Differential Effects of Peptide Hormones Bombesin, Vasoactive Intestinal Polypeptide and Somatostatin Analog RC-160 on the Invasive Capacity of Human Prostatic Carcinoma Cells

1993 • 149 citations

Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases.

1996 • 143 citations

Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.

1995 • 128 citations

RNA Genetics of Breast Cancer: Maspin as Paradigm

1994 • 123 citations

Positive and negative transcriptional elements of the human type IV collagenase gene.

1990 • 121 citations

MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells.

1997 • 116 citations

A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene.

1993 • 112 citations

Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

1993 • 98 citations

Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro.

1994 • 98 citations

Thrombospondin-1 (TSP-1) Promotes the Invasive Properties of Human Breast Cancer

1996 • 92 citations

Characteristics of an infinite life span diploid human fibroblast cell strain and a near-diploid strain arising from a clone of cells expressing a transfectedv-myc oncogene

1991 • 85 citations

1α,25-Dihydroxyvitamin D3 inhibits the invasive potential of human breast cancer cellsin vitro

1994 • 84 citations

Expression of 72 kDa type IV collagenase and invasion activity of human glioma cells

1994 • 81 citations

Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate

1990 • 75 citations

Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene.

1989 • 73 citations

Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

1996 • 63 citations

Stromelysin-3 in stromal tissue as a control factor in breast cancer behavior

1994 • 61 citations

Molecular basis of tumour metastasis.

1993 • 53 citations

Il‐1β and prostaglandins regulate integrin mRNA expression

1991 • 51 citations

Modulation of proteases and their inhibitors in immortal human osteoblast-like cells by tumor necrosis factor-alpha in vitro

1994 • 47 citations

Secretion of gelatinases and tissue inhibitors of metalloproteinases by human lung cancer cell lines and revertant cell lines: Not an invariant correlation with metastasis

1992 • 46 citations

Recombinant human uteroglobin inhibits the in vitro invasiveness of human metastatic prostate tumor cells and the release of arachidonic acid stimulated by fibroblast-conditioned medium.

1994 • 41 citations

Suppression of type IV collagenase in MDA-MB-435 human breast cancer cells by eicosapentaenoic acid in vitro and in vivo

1995 • 41 citations

Regulation of integrin gene expression by substrate adherence.

1992 • 36 citations

Expression of type‐IV collagenases in human tumor cell lines that can form liver colonies in chick embryos

1994 • 36 citations

Regulation of matrix metalloproteinases following cellular transformation

1996 • 35 citations

Malignant transformation of human fibroblasts by a transfected N-ras oncogene.

1990 • 31 citations

Autocrine regulation of collagenase gene expression by TNF-α in U937 cells

1996 • 24 citations

Gross Factors in Treatment of Nonhealing Corneal Ulcers and Recurrent Erosions

1989 • 24 citations

Malignant transformation of an infinite life span human fibroblast cell strain by transfection with v-Ki-ras.

1990 • 22 citations

Controls for validation of relative reverse transcription--polymerase chain reaction assays.

1993 • 22 citations

HL-60 leukemia cells produce an autocatalytically truncated form of matrix metalloproteinase-9 with impaired sensitivity to inhibition by tissue inhibitors of metalloproteinases.

1996 • 20 citations

Immunoassays of the metalloproteinase (MMP-2) and tissue inhibitor of metalloproteinase (TIMP 1 and 2) levels in noninvasive and metastatic PC-3 clones: effects of taxol.

1994 • 20 citations

Loss of collagenase gene expression in immortalized clones of SV40 T antigen-transformed human diploid fibroblasts

1992 • 19 citations

bFGF Stimulates U937 Cell Adhesion to Fibronectin and Secretion of Gelatinase B

1996 • 18 citations

α5 Integrin subunit expression changes during myogenesis

1992 • 18 citations

Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family.

1997 • 18 citations

Use of stock solutions to simplify mRNA quantitation by reverse transcription--PCR assays.

1993 • 15 citations

/-sis oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumors

1994 • 14 citations

Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator

1996 • 12 citations

Modulation of expression of endogenous collagenase and collagen genes by electroporation: possible involvement of Ca2+ and protein kinase C

1993 • 11 citations

Increased expression of the matrix metalloproteinase 2 in differentiating tera 2 human embryonal carcinoma cells

1994 • 10 citations

Oncogenes Control Stromelysin and Collagenase Gene Expression

2015 • 9 citations

Coordinated expression of matrilysin during TPA-induced apoptosis of LNCaP cells: two parallel processes affected by TPA

1997 • 9 citations

Malignant transformation of a human fibroblast cell strain by transfection of a v-fes oncogene but not by transfection of a gag-human c-fes construct.

1994 • 8 citations

IS‐RT‐PCR assay detection of MT‐MMP in a human breast cancer cell line

1996 • 7 citations

Malignant transformation of human fibroblast strain MSU‐1.1 by v‐fes requires an additional genetic change

1995 • 6 citations

Analysis of the multistep nature of human carcinogenesis utilizing human fibroblasts

1995 • 2 citations

Transfection of amyc gene as a means of generating infinite life span human fibroblast strains

1995 • 1 citations