Intrinsic or acquired drug resistance and metastasis: Are they linked phenotypes?

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Mechanism of multidrug resistance

1988 • 630 citations

The incidence of p53 mutations increases with progression of head and neck cancer.

1993 • 602 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

1990 • 408 citations

Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

1990 • 313 citations

Acquired multicellular-mediated resistance to alkylating agents in cancer.

1993 • 280 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

1993 • 238 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects

1990 • 179 citations

Drug Resistance in Oncology

1994 • 173 citations

Drug Resistance in Oncology

1997 • 160 citations

Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenes.

1988 • 156 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection.

1987 • 120 citations

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

1993 • 120 citations

Overexpression of p53 is a late event in the development of malignant melanoma.

1993 • 115 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.

1988 • 105 citations

Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations.

1988 • 97 citations

Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes

1991 • 90 citations

Expression of the c-Ha-ras oncogene in mouse NIH 3T3 cells induces resistance to cisplatin.

1991 • 86 citations

Identification of a membrane glycoprotein overexpressed in murine lymphoma sublines resistant to cis-diamminedichloroplatinum(II).

1990 • 85 citations

Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine.

1984 • 85 citations

Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-ras-transformed cloned rat embryo fibroblast cells.

1993 • 69 citations

Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

1986 • 65 citations

Selection of metastatic variants with identifiable karyotypic changes from a nonmetastatic murine tumor after treatment with 2'-deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression.

1987 • 49 citations

Genetic Tagging of Tumor Cells with Retrovirus Vectors: Clonal Analysis of Tumor Growth and Metastasis In Vivo

1988 • 38 citations

Dominance of metastatically competent cells in primary murine breast neoplasms is necessary for distant metastatic spread

1991 • 36 citations

FACILITATION OF TUMOUR PROGRESSION BY CANCER THERAPY

1982 • 34 citations

Amplified pulmonary metastases of a rat rhabdomyosarcoma in response to nitrosourea treatment.

1984 • 33 citations

Can cancer chemotherapy enhance the malignant behaviour of tumours?

1987 • 31 citations

Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo.

1988 • 30 citations

Expression of mdr1 gene in human breast primary tumors and metastases

1993 • 25 citations

Characterization in vitro and in vivo of progressively adriamycin-resistant B16-BL6 mouse melanoma cells.

1987 • 23 citations

Isolation of variants resistant to methylglyoxal bis(guanylhydrazone) from adenovirus-transformed rat cells.

1987 • 21 citations

Metastatic behavior of an adriamycin-resistant murine tumor.

1983 • 21 citations

Oncogene and MDR1 gene expression in rat rhabdomyosarcoma sublines of different metastatic potential.

1991 • 18 citations

Transformation of rat ovarian epithelial and Rat-1 fibroblast cell lines by RAST24 does not influence cisplatin sensitivity.

1993 • 18 citations

Actinomycin‐D‐resistant in vitro mouse cell line derived from a methylcholanthrene‐induced sarcoma: Decrease of malignancy and antigenic characteristics

1974 • 17 citations

Drug resistance in kht fibrosarcoma cell lines with different metastatic ability

1989 • 16 citations

In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates.

1990 • 15 citations

New insights into the evolutionary growth of tumors revealed by southern gel analysis of tumors genetically tagged with plasmid or proviral dna insertions

1989 • 14 citations

In vivo emergence of a highly metastatic tumour cell line from a rat rhabdomyosarcoma after treatment with an alkylating agent

1988 • 12 citations

Chlorozotocin-induced selection of autocrine and multidrug resistant variants from a rat rhabdomyosarcoma.

1988 • 2 citations