In vivo plasma membrane organization: results of biophysical approaches

Functional rafts in cell membranes

1997 • 9,471 citations

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Zwischenmolekulare Energiewanderung und Fluoreszenz

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Lipid rafts and signal transduction

2000 • 6,079 citations

Acceleration and Trapping of Particles by Radiation Pressure

1970 • 4,658 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

1976 • 2,658 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking

2003 • 1,455 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution

1995 • 1,029 citations

Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells

1993 • 1,002 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Single-molecule imaging of EGFR signalling on the surface of living cells

2000 • 884 citations

Phospholipids undergo hop diffusion in compartmentalized cell membrane

2002 • 878 citations

Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

2004 • 865 citations

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

2003 • 728 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Insolubility of lipids in Triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)

2000 • 677 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Resistance of cell membranes to different detergents

2003 • 647 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

Imaging of single molecule diffusion.

1996 • 611 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Role of cholesterol in lipid raft formation: lessons from lipid model systems

2003 • 566 citations

Lateral diffusion in the liquid phases of dimyristoylphosphatidylcholine/cholesterol lipid bilayers: a free volume analysis

1992 • 563 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

2001 • 525 citations

Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model

2003 • 513 citations

Constrained diffusion or immobile fraction on cell surfaces: a new interpretation

1996 • 469 citations

Revisiting the Fluid Mosaic Model of Membranes

1995 • 457 citations

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

1999 • 456 citations

Distribution of a Glycosylphosphatidylinositol-anchored Protein at the Apical Surface of MDCK Cells Examined at a Resolution of <100 Å Using Imaging Fluorescence Resonance Energy Transfer

1998 • 452 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

Relationship of Lipid Rafts to Transient Confinement Zones Detected by Single Particle Tracking

2002 • 418 citations

Looking at lipid rafts?

1999 • 406 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Cell surface organization by the membrane skeleton

1996 • 378 citations

Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization

2003 • 342 citations

Single metallic nanoparticle imaging for protein detection in cells

2003 • 339 citations

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

2001 • 329 citations

Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecules

1994 • 320 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

Single Molecule Imaging of Green Fluorescent Proteins in Living Cells: E-Cadherin Forms Oligomers on the Free Cell Surface

2001 • 309 citations

Transient Confinement of a Glycosylphosphatidylinositol-Anchored Protein in the Plasma Membrane

1997 • 303 citations

Caveolae: anchored, multifunctional platforms in the lipid ocean

2003 • 301 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

Plasma membrane microdomains

2002 • 290 citations

Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry

1999 • 288 citations

Cholesterol depletion induces large scale domain segregation in living cell membranes

2001 • 287 citations

Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade

2002 • 283 citations

Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis.

1994 • 268 citations

Insights into lipid raft structure and formation from experiments in model membranes

2002 • 260 citations

Imaging of Cell/Substrate Contacts of Living Cells with Surface Plasmon Resonance Microscopy

1999 • 260 citations

Lateral diffusion in phospholipid multibilayers measured by fluorescence recovery after photobleaching

1977 • 258 citations

Lateral Movements of Membrane Glycoproteins Restricted by Dynamic Cytoplasmic Barriers

1991 • 250 citations

Detection of temporary lateral confinement of membrane proteins using single-particle tracking analysis

1995 • 249 citations

Lipid microdomains in cell surface membranes

1997 • 245 citations

Translational Diffusion of Individual Class II MHC Membrane Proteinsin Cells

2002 • 241 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Lipid polarity and sorting in epithelial cells

1988 • 236 citations

Micrometer-scale domains in fibroblast plasma membranes.

1987 • 236 citations

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

2000 • 233 citations

Cytoplasmic Regulation of the Movement of E-Cadherin on the Free Cell Surface as Studied by Optical Tweezers and Single Particle Tracking: Corralling and Tethering by the Membrane Skeleton

1998 • 231 citations

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

2002 • 220 citations

Autofluorescent Proteins in Single-Molecule Research: Applications to Live Cell Imaging Microscopy

2001 • 217 citations

Luminescence Digital Imaging Microscopy

1989 • 214 citations

Barriers for lateral diffusion of transferrin receptor in the plasma membrane as characterized by receptor dragging by laser tweezers: fence versus tether.

1995 • 213 citations

Lateral mobility of band 3 in the human erythrocyte membrane studied by fluorescence photobleaching recovery: Evidence for control by cytoskeletal interactions

1980 • 212 citations

Regulation Mechanism of the Lateral Diffusion of Band 3 in Erythrocyte Membranes by the Membrane Skeleton

1998 • 203 citations

Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

2003 • 202 citations

Lipid raft proteins have a random distribution during localized activation of the T-cell receptor

2004 • 200 citations

Cholesterol Depletion Disrupts Caveolae and Differentially Impairs Agonist-Induced Arterial Contraction

2002 • 181 citations

Single-Molecule Imaging of L-Type Ca2+ Channels in Live Cells

2001 • 180 citations

Anomalous Diffusion of Major Histocompatibility Complex Class I Molecules on HeLa Cells Determined by Single Particle Tracking

1999 • 174 citations

Restriction of the lateral motion of band 3 in the erythrocyte membrane by the cytoskeletal network: dependence on spectrin association state

1986 • 167 citations

The Sensitivity of Lipid Domains to Small Perturbations Demonstrated by the Effect of Triton

2003 • 164 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Cholesterol Does Not Induce Segregation of Liquid-Ordered Domains in Bilayers Modeling the Inner Leaflet of the Plasma Membrane

2001 • 144 citations

Single-Molecule Imaging of the H-Ras Membrane-Anchor Reveals Domains in the Cytoplasmic Leaflet of the Cell Membrane

2004 • 137 citations

Different Sphingolipids Show Differential Partitioning into Sphingolipid/Cholesterol-Rich Domains in Lipid Bilayers

2000 • 136 citations

Membrane organization in immunoglobulin E receptor signaling

1999 • 135 citations

Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains.

1991 • 126 citations

Cross-Correlation Analysis of Inner-Leaflet-Anchored Green Fluorescent Protein Co-Redistributed with IgE Receptors and Outer Leaflet Lipid Raft Components

2001 • 120 citations

Truncation mutants define and locate cytoplasmic barriers to lateral mobility of membrane glycoproteins.

1994 • 113 citations

Monte Carlo simulation studies of lipid order parameter profiles near integral membrane proteins

1991 • 107 citations

Characterization of proteins in detergent-resistant membrane complexes from Madin-Darby canine kidney epithelial cells

1995 • 98 citations

A Model for Membrane Patchiness: Lateral Diffusion in the Presence of Barriers and Vesicle Traffic

1999 • 76 citations

Simultaneous dual-color and dual-polarization imaging of single molecules

2000 • 75 citations

Effect of hydrodynamic interactions on the diffusion of integral membrane proteins: diffusion in plasma membranes

1995 • 72 citations

Numerical simulations of the effect of hydrodynamic interactions on diffusivities of integral membrane proteins

1995 • 71 citations

Imaging metabolism of phosphatidylinositol 4,5-bisphosphate in t-cell GM1-enriched domains containing Ras proteins☆

2003 • 67 citations

Mechanism of Lck Recruitment to the T‐Cell Receptor Cluster as Studied by Single‐Molecule‐Fluorescence Video Imaging

2003 • 64 citations

Detection of Dimers of Dimers of Human Leukocyte Antigen (HLA)–DR on the Surface of Living Cells by Single-Particle Fluorescence Imaging

1998 • 62 citations

Regulation of Protein Mobility via Thermal Membrane Undulations

2003 • 60 citations

Single particle tracking of cell-surface HLA-DR molecules using R-phycoerythrin labeled monoclonal antibodies and fluorescence digital imaging

1996 • 60 citations

Molecular counting of low-density lipoprotein particles as individuals and small clusters on cell surfaces

1986 • 58 citations

Binding of Cross-Linked Glycosylphosphatidylinositol-Anchored Proteins to Discrete Actin-Associated Sites and Cholesterol-Dependent Domains

2001 • 56 citations

Partitioning of Amphiphiles between Coexisting Ordered and Disordered Phases in Two-Phase Lipid Bilayer Membranes

2000 • 44 citations

Vesicle Trafficking and Cell Surface Membrane Patchiness

2001 • 42 citations

Lowering the Barriers to Random Walks on the Cell Surface

2003 • 32 citations

Detecting and Quantifying Colocalization of Cell Surface Molecules by Single Particle Fluorescence Imaging

2003 • 24 citations

Fluctuations and membrane heterogeneity

1995 • 19 citations

Analysis of receptor clustering on cell surfaces by imaging fluorescent particles

1994 • 19 citations

Detection of gold probes with video‐enhanced contrast microscopy: Nanovid microscopy

1989 • 10 citations