Tyrosine phosphorylation of p62 ^dok by p210 ^bcr-abl inhibits RasGAP activity

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Untitled

1998 • 523 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.

1993 • 205 citations

The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

1999 • 194 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

1997 • 156 citations

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway.

1996 • 146 citations

Erythropoietin Induces the Tyrosine Phosphorylation of GAB1 and Its Association With SHC, SHP2, SHIP, and Phosphatidylinositol 3-Kinase

1999 • 113 citations

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.

1994 • 109 citations

Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62

1992 • 78 citations

Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

1993 • 62 citations

[18] Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays

1995 • 57 citations

Implication of GAP in Ras-Dependent Transactivation of a Polyoma Enhancer Sequence

1992 • 56 citations

Protein-Tyrosine Kinases Regulate the Phosphorylation, Protein Interactions, Subcellular Distribution, and Activity of p21^rasGTPase-Activating Protein

1991 • 50 citations

Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation.

1992 • 49 citations

Suppression of RAS and MOS transformation by radicicol.

1995 • 47 citations

Activation of Tyrosine Kinase and Microfilament-Binding Functions of c-abl by bcr Sequences in bcr/abl Fusion Proteins

1991 • 47 citations

A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations.

1994 • 34 citations

Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells.

1993 • 22 citations

Characterization of lineage-negative blast subpopulations derived from normal and chronic myelogenous leukemia bone marrows and determination of their responsiveness to human c-kit ligand.

1993 • 20 citations

The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.

1994 • 18 citations

Specific Changes of Ras GTPase-Activating Protein (GAP) and a GAP-Associated p62 Protein during Calcium-Induced Keratinocyte Differentiation

1992 • 9 citations

A Universal Tag for Recombinant Proteins

1996 • 7 citations