Intracellular Movement of Green Fluorescent Protein–Tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Oncogenes and signal transduction

1991 • 2,816 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Receptor clustering as a cellular mechanism to control sensitivity

1998 • 617 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Phosphoinositide kinases

1996 • 529 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired

1996 • 452 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera.

1994 • 354 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1994 • 245 citations

p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes

1997 • 243 citations

Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-Kinase

1995 • 239 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase

1997 • 224 citations

Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency

1998 • 208 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

ErbB3 Is Involved in Activation of Phosphatidylinositol 3-Kinase by Epidermal Growth Factor

1994 • 194 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin.

1996 • 180 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.

1993 • 173 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein

1997 • 164 citations

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.

1993 • 162 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells

1996 • 143 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

Characterization of VPS34, a Gene Required for Vacuolar Protein Sorting and Vacuole Segregation in Saccharomyces cerevisiae†

1990 • 126 citations

Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains

1992 • 123 citations

Wortmannin, an Inhibitor of Phosphoinositide 3-Kinase, Inhibits Transcytosis in Polarized Epithelial Cells

1995 • 112 citations

Overexpressed Csk Tyrosine Kinase Is Localized in Focal Adhesions, Causes Reorganization of α_vβ₅ Integrin, and Interferes with Hela Cell Spreading

1995 • 112 citations

Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function.

1985 • 104 citations

Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins.

1994 • 96 citations

The Proto-oncogene Product p120 Links c-Src and Phosphatidylinositol 3′-Kinase to the Integrin Signaling Pathway

1997 • 94 citations

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis

1997 • 77 citations

Protein regulation by phosphatidylinositol lipids

1995 • 53 citations

Purification of the neurotensin receptor from bovine brain.

1988 • 52 citations

The v-Src SH3 Domain Binds Phosphatidylinositol 3'-Kinase

1993 • 52 citations

A Novel Recognition Motif for Phosphatidylinositol 3-Kinase Binding Mediates Its Association with the Hepatocyte Growth Factor/Scatter Factor Receptor

1993 • 49 citations

Heregulin Degradation in the Absence of Rapid Receptor-Mediated Internalization

1997 • 44 citations

Internalization of Activated Platelet-Derived Growth Factor Receptor-Phosphatidylinositol-3' Kinase Complexes: Potential Interactions with the Microtubule Cytoskeleton

1993 • 43 citations

Identification of Four Novel Human Phosphoinositide 3-Kinases Defines a Multi-isoform Subfamily

1997 • 40 citations

Microinjection of the SH2 Domain of the 85-Kilodalton Subunit of Phosphatidylinositol 3-Kinase Inhibits Insulin-Induced DNA Synthesis and c-fos Expression

1994 • 24 citations