Signal transduction via the histidyl‐aspartyl phosphorelay

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Molecular basis of bacterial outer membrane permeability

1985 • 2,171 citations

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS

1992 • 1,449 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

Signal transduction schemes of bacteria

1993 • 781 citations

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

1993 • 739 citations

Signal transduction in bacteria

1990 • 683 citations

A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA).

1984 • 676 citations

Coordinate Regulation and Sensory Transduction in the Control of Bacterial Virulence

1989 • 626 citations

Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis

1988 • 550 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.

1992 • 475 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled

1996 • 427 citations

Stress signaling in yeast

1995 • 415 citations

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

1995 • 356 citations

Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis

1989 • 350 citations

Assembly of an MCP receptor, CheW, and kinase CheA complex in the bacterial chemotaxis signal transduction pathway

1992 • 333 citations

Influence of osmolarity of the growth medium on the outer membrane protein pattern of Escherichia coli

1977 • 326 citations

Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis

1988 • 316 citations

Structure of the Escherichia coli Response Regulator NarL^,

1996 • 313 citations

From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli

1996 • 305 citations

Crystal structure of Escherichia coli CheY refined at 1.7-A resolution.

1991 • 293 citations

Structural conservation in the CheY superfamily

1993 • 288 citations

Two-Component Signal Transduction Systems: Structure-Function Relationships and Mechanisms of Catalysis

2014 • 258 citations

Is acetyl phosphate a global signal in Escherichia coli?

1993 • 257 citations

Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance

1993 • 252 citations

Role of water in some biological processes

1990 • 248 citations

The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor

1997 • 236 citations

Osmotic regulation of transcription: induction of the proU betaine transport gene is dependent on accumulation of intracellular potassium

1986 • 229 citations

Activation of Bacterial Porin Gene Expression by a Chimeric Signal Transducer in Response to Aspartate

1989 • 207 citations

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

Induction of Gene Expression in Escherichia coli After Pilus-Mediated Adherence

1996 • 188 citations

EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes

1991 • 186 citations

Oligomerization of NTRC at the glnA enhancer is required for transcriptional activation.

1993 • 182 citations

Histidine and aspartate phosphorylation: two-component systems and the limits of homology

1994 • 181 citations

cis-acting ompF mutations that result in OmpR-dependent constitutive expression

1991 • 175 citations

Localization and membrane topology of EnvZ, a protein involved in osmoregulation of OmpF and OmpC in Escherichia coli.

1987 • 174 citations

The downstream box: an efficient and independent translation initiation signal in Escherichia coli.

1996 • 171 citations

Osmotic regulation of gene expression

1996 • 170 citations

The glycine-rich sequence of protein kinases: a multifunctional element

1994 • 165 citations

EnvZ, a transmembrane environmental sensor of Escherichia coli K-12, is phosphorylated in vitro

1988 • 164 citations

Osmotic regulation of gene expression: ionic strength as an intracellular signal?

1987 • 162 citations

Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli.

1991 • 160 citations

Primary characterization of the protein products of the Escherichia coli ompB locus: structure and regulation of synthesis of the OmpR and EnvZ proteins

1985 • 159 citations

Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NRII or NtrB): trans-phosphorylation between subunits

1993 • 158 citations

Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.

1994 • 155 citations

Genistein inhibits protein histidine kinase.

1992 • 154 citations

The response regulator-like protein Pos9/Skn7 ofSaccharomyces cerevisiae is involved in oxidative stress resistance

1996 • 151 citations

Modular structure of Fix J: homology of the transcriptional activator domain with the ‐35 binding domain of sigma factors

1991 • 149 citations

Intermolecular complementation of the kinase activity of CheA

1993 • 129 citations

Overexpression and sequence of the Escherichia coli cheY gene and biochemical activities of the CheY protein

1984 • 129 citations

A novel sensor‐regulator protein that belongs to the homologous family of signal‐transduction proteins involved in adaptive responses in Escherichia coli

1992 • 128 citations

Transmembrane signalling by a hybrid protein: communication from the domain of chemoreceptor Trg that recognizes sugar-binding proteins to the kinase/phosphatase domain of osmosensor EnvZ

1994 • 127 citations

Characterization of the osmotic-stress response inSaccharomyces cerevisiae: osmotic stress and glucose repression regulate glycerol-3-phosphate dehydrogenase independently

1994 • 126 citations

Nucleotide sequence of the phoR gene, a regulatory gene for the phosphate regulon of Escherichia coli

1986 • 125 citations

Signal transduction by the EnvZ-OmpR phosphotransfer system in bacteria

1994 • 124 citations

Tandem Binding of Six OmpR Proteins to the ompF Upstream Regulatory Sequence of Escherichia coli

1995 • 124 citations

Nucleotide sequence of the uhp region of Escherichia coli

1987 • 123 citations

GENETIC REGULATION OF BACTERIAL VIRULENCE

1989 • 123 citations

Suppressor mutations in rpoA suggest that OmpR controls transcription by direct interaction with the alpha subunit of RNA polymerase

1991 • 113 citations

Multiple forms of the CheB methylesterase in bacterial chemosensing.

1985 • 110 citations

Inhibitors of two-component signal transduction systems: inhibition of alginate gene activation in Pseudomonas aeruginosa.

1993 • 106 citations

DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins.

1985 • 101 citations

Identification of the Bases in theompFRegulatory Region, which Interact with the Transcription Factor OmpR

1996 • 96 citations

Role of uhp genes in expression of the Escherichia coli sugar-phosphate transport system

1988 • 95 citations

The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli

1993 • 95 citations

Identification of the DNA-binding domain of the OmpR protein required for transcriptional activation of the ompF and ompC genes of Escherichia coli by in vivo DNA footprinting

1989 • 94 citations

Porin Regulon ofEscherichia coli

2014 • 94 citations

The OmpR protein of Escherichia coli binds to sites in the ompF promoter region in a hierarchical manner determined by its degree of phosphorylation.

1994 • 93 citations

Novel Members of the Two-Component Signal Transduction Genes in Escherichia coli1

1993 • 90 citations

Attractant Signaling by an Aspartate Chemoreceptor Dimer with a Single Cytoplasmic Domain

1996 • 86 citations

Regulation of ompC and ompF expression in Escherichia coli in the absence of envZ

1988 • 83 citations

Requirement of Both Kinase and Phosphatase Activities of an Escherichia coli Receptor (Taz1) for Ligand-dependent Signal Transduction

1993 • 83 citations

Ligand Binding to the Receptor Domain Regulates the Ratio of Kinase to Phosphatase Activities of the Signaling Domain of the Hybrid Escherichia coli Transmembrane Receptor, Taz1

1993 • 83 citations

Newly identified genes involved in the signal transduction of Escherichia coli K-12

1994 • 81 citations

Phosphorylation-dependent binding of the chemotaxis signal molecule CheY to its phosphatase, CheZ

1994 • 77 citations

Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.

1993 • 76 citations

ATP‐dependent protein kinases in bacteria

1993 • 74 citations

Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon

1986 • 74 citations

The complete nucleotide sequence of the ginALG operon ofEscherichia coliK12

1987 • 73 citations

Mucoid Pseudomonas aeruginosa in cystic fibrosis: signal transduction and histone‐like elements in the regulation of bacterial virulence

1991 • 73 citations

Static bend of DNA helix at the activator recognition site of the ompF promoter in Escherichia coli

1987 • 72 citations

Refined Structures of the Ligand-binding Domain of the Aspartate Receptor from Salmonella typhimurium

1993 • 72 citations

Reverse Phosphotransfer from OmpR to EnvZ in a Kinase−/Phosphatase+ Mutant of EnvZ (EnvZ•N347D), a Bifunctional Signal Transducer of Escherichia coli

1996 • 71 citations

Identification and characterization of narQ, a second nitrate sensor for nitrate‐dependent gene regulation in Escherichia coli

1992 • 69 citations

Nucleoside-diphosphate Kinase-mediated Signal Transduction via Histidyl-Aspartyl Phosphorelay Systems in Escherichia coli

1996 • 68 citations

Signaling by the Escherichia coli Aspartate Chemoreceptor Tar with a Single Cytoplasmic Domain per Dimer

1996 • 67 citations

Control of Cellular Development in Sporulating Bacteria by the Phosphorelay Two-Component Signal Transduction System

2014 • 67 citations

Control of Nitrogen Assimilation by the NR_I-NR_IITwo-Component System of Enteric Bacteria

2014 • 62 citations

Mapping of a gene for a major outer membrane protein ofEscherichia coli K12 with the aid of a newly isolated bacteriophage

1977 • 61 citations

Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol‐3‐phosphate dehydrogenase, one of which is responsible for osmotolerance for growth

1995 • 61 citations

Identification of the site of phosphorylation on the osmosensor, EnvZ, of Escherichia coli.

1994 • 60 citations

Identification of base pairs important for OmpR‐DNA interaction

1995 • 58 citations

Molecular analysis of the Escherichia coli phoP-phoQ operon

1992 • 57 citations

OmpR mutants specifically defective for transcriptional activation

1994 • 56 citations

Structural and Functional Conservation in Response Regulators

2014 • 55 citations

A distant upstream site involved in the negative regulation of the Escherichia coli ompF gene

1994 • 54 citations

Altered osmoregulation of ompF in integration host factor mutants of Escherichia coli

1988 • 53 citations

Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors

2014 • 52 citations

The Cpx proteins of Escherichia coli K12. Immunologic detection of the chromosomal cpxA gene product.

1986 • 48 citations

H-NS regulates OmpF expression through micF antisense RNA in Escherichia coli

1996 • 48 citations

Re‐examination of the role of the periplasmic domain of EnvZ in sensing of osmolarity signals in Escherichia coli

1996 • 43 citations

Introduction: Protein phosphorylation and signal transduction in bacteria

1993 • 42 citations

Nitrate regulation of anaerobic respiratory gene expression in narX deletion mutants of Escherichia coli K-12

1990 • 41 citations

Transmembrane Signal Transduction and Osmoregulation in Escherichia coli: I. Analysis by Site-Directed Mutagenesis of the Amino Acid Residues Involved in Phosphotransfer between the Two Regulatory Components, EnvZ and OmpR1

1990 • 40 citations

Molecular analysis of the two‐component genes, ompR and envZ, in the symbiotic bacterium Xenorhabdus nematophilus

1995 • 33 citations

DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro‐OmpC protein in Escherichia coli

1983 • 31 citations

Receptor signaling: Dimerization and beyond

1996 • 29 citations

Characterization of OmpR binding sequences in the upstream region of the ompF promoter essential for transcriptional activation

1989 • 26 citations

Gene Activation by the Escherichia coli Positive Regulator, OmpR

1994 • 24 citations

Functional and regulatory analysis of the OmpF‐like porin, OpnP, of the symbiotic bacterium Xenorhabdus nematophilus

1995 • 23 citations

Purification and Characterization of the Periplasmic Domain of EnvZ Osmosensor inEscherichia coli

1997 • 18 citations

A dominant mutation in Escherichia coli OmpR lies within a domain which is highly conserved in a large family of bacterial regulatory proteins

1988 • 17 citations

[17] Analyzing protein phosphorylation in prokaryotes

1991 • 16 citations

Molecular characterization of a 40 kDa OmpC-like porin from Serratia marcescens

1994 • 16 citations

Crystallization and X-ray Studies of the DNA-binding Domain of OmpR Protein, a Positive Regulator Involved in Activation of Osmoregulatory Genes in Escherichia coli

1994 • 13 citations

Crystallization, X‐ray studies, and site‐directed cysteine mutagenesis of the DNA‐binding domain of OmpR

1996 • 12 citations

[8] Micromethod for the measurement of acetyl phosphate and acetyl coenzyme A

1986 • 10 citations