GENETIC REGULATION OF BACTERIAL VIRULENCE

Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines

1981 • 2,042 citations

Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin.

1987 • 1,041 citations

A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli

1988 • 719 citations

Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells

1987 • 599 citations

Genetic Switch

2008 • 590 citations

STUDIES ON GONOCOCCUS INFECTION

1973 • 581 citations

A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells

1989 • 556 citations

Regulation of ferric iron transport in Escherichia coli K12: Isolation of a constitutive mutant

1981 • 554 citations

Conserved domains in bacterial regulatory proteins that respond to environmental stimuli

1987 • 537 citations

Isolation and Characterization of Gal E Mutant Ty 21a of Salmonella typhi: A Candidate Strain for a Live, Oral Typhoid Vaccine

1975 • 521 citations

Cascades of sigma factors

1981 • 445 citations

Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes

1986 • 431 citations

Opacity genes in Neisseria gonorrhoeae: Control of phase and antigenic variation

1986 • 428 citations

Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC.

1988 • 365 citations

Pilus expression in neisseria gonorrhoeae involves chromosomal rearrangement

1982 • 332 citations

Fimbrial Adhesins of Escherichia coli

1985 • 323 citations

Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.

1984 • 320 citations

Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization

1988 • 304 citations

Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins

1984 • 289 citations

Non-Flagellar Appendages of Bacteria

1959 • 283 citations

Genetic analysis of phase change in Bordetella pertussis

1984 • 278 citations

Phase Variation of Type 1 Fimbriae in Escherichia coli Is Under Transcriptional Control

1981 • 267 citations

Homology between virF, the transcriptional activator of the Yersinia virulence regulon, and AraC, the Escherichia coli arabinose operon regulator

1989 • 263 citations

Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae

1989 • 257 citations

Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system

1989 • 241 citations

The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs to a class of environmentally responsive genes

1989 • 225 citations

Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.

1988 • 217 citations

Role of chromosomal rearrangement in N. gonorrhoeae pilus phase variation

1985 • 215 citations

Genetic analysis of the low calcium response in Yersinia pestis mu d1(Ap lac) insertion mutants

1984 • 213 citations

Control of phage λ development by stability and synthesis of cll protein: Role of the viral clll and host hflA, himA and himD genes

1982 • 210 citations

Effects of recA Mutations on Pilus Antigenic Variation and Phase Transitions in Neisseria gonorrhoeae

1987 • 206 citations

DNA transformation leads to pilin antigenic variation in Neisseria gonorrhoeae

1988 • 188 citations

Fimbrial phase variation in Escherichia coli: dependence on integration host factor and homologies with other site-specific recombinases

1987 • 181 citations

The fim genes responsible for synthesis of type 1 fimbriae in Escherichia coli, cloning and genetic organization

1985 • 180 citations

Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis

1988 • 177 citations

Transcriptional activation of a pap pilus virulence operon from uropathogenic Escherichia coli.

1985 • 175 citations

Gene conversion involving the pilin structural gene correlates with pilus+ ⇄ pilus− changes in Neisseria gonorrhoeae

1986 • 168 citations

Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus

1988 • 164 citations

Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments.

1986 • 161 citations

Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroinvasive Escherichia coli

1985 • 161 citations

Secretion of Haemolysin by Escherichia coli

1986 • 146 citations

Integration host factor is required for the DNA inversion that controls phase variation in Escherichia coli.

1987 • 140 citations

Size variation of the M protein in group A streptococci.

1985 • 133 citations

Antigenic heterogeneity of gonococcal pili.

1975 • 121 citations

lac Repressor blocks transcribing RNA polymerase and terminates transcription.

1986 • 120 citations

Double-stranded cleavage of T-DNA and generation of single-stranded T-DNA molecules in Escherichia coli by a virD-encoded border-specific endonuclease from Agrobacterium tumefaciens

1987 • 117 citations

Recombination among Protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the Protein II family

1988 • 113 citations

Mannose-Binding Activity of Escherichia coli: a Determinant of Attachment and Ingestion of the Bacteria by Macrophages

1980 • 109 citations

Pilus- gonococcal variants. Evidence for multiple forms of piliation control.

1985 • 104 citations

Pilin expression in Neisseria gonorrhoeae is under both positive and negative transcriptional control.

1988 • 103 citations

Comparison of Virulence Markers of Peritoneal and Fallopian Tube Isolates with Endocervical Neisseria gonorrhoeae Isolates from Women with Acute Salpingitis

1980 • 103 citations

Mediation of Serum Resistance in Salmonella typhimurium by an 11-Kilodalton Polypeptide Encoded by the Cryptic Plasmid

1987 • 98 citations

Growth advantage and enhanced toxicity of Escherichia coli adherent to tissue culture cells due to restricted diffusion of products secreted by the cells.

1987 • 95 citations

Genes involved in Haemophilus influenzae type b capsule expression are part of an 18-kilobase tandem duplication.

1986 • 92 citations

The Colonization of Peyer's Patches by a Strain of Salmonella typhimurium Cured of the Cryptic Plasmid

1986 • 90 citations

Metastable regulation of type 1 piliation in Escherichia coli and isolation and characterization of a phenotypically stable mutant

1986 • 90 citations

Two modes of control of pilA, the gene encoding type 1 pilin in Escherichia coli

1985 • 89 citations

Identification of carbohydrate structures that are possible receptors for Neisseria gonorrhoeae.

1988 • 86 citations

Genetic analysis of the phase variation control of expression of type 1 fimbriae in Escherichia coli

1985 • 84 citations

Spontaneous M6 protein size mutants of group A streptococci display variation in antigenic and opsonogenic epitopes.

1988 • 83 citations

Involvement of the invertible G segment in bacteriophage Mu tail fiber biosynthesis

1984 • 78 citations

Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703

1988 • 77 citations

Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes

1988 • 75 citations

Construction of delta aroA his delta pur strains of Salmonella typhi

1988 • 73 citations

Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa

1988 • 69 citations

125I-labeled peptide mapping of some heat-modifiable proteins of the gonococcal outer membrane

1980 • 53 citations

Bordetella parapertussis invasion of HeLa 229 cells and human respiratory epithelial cells in primary culture

1989 • 52 citations

Antigenic Variation of Outer Membrane Protein II in Colonial Variants of Neisseria gonorrhoeae P9

1982 • 51 citations

Nucleotide sequence and characterization oftoxR: a gene involved in exotoxin A regulation inPseudomonas aeruginosa

1987 • 49 citations

Streptococcal M protein size mutants occur at high frequency within a single strain.

1986 • 47 citations

Iron regulation of the cloned diphtheria toxin promoter in Escherichia coli

1988 • 44 citations

Genetics of pertussis toxin

1989 • 43 citations

Genetic mapping and transcriptional orientation of the fimD gene

1983 • 36 citations

Genetic complementation analysis of Escherichia coli type 1 somatic pilus mutants

1977 • 34 citations

Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence

1989 • 28 citations

Acceleration of starvation- and glycerol-induced myxospore formation by prior heat shock in Myxococcus xanthus

1988 • 23 citations

Regulation of Cholera Toxin Synthesis

1990 • 15 citations

Genetic Studies of Enterotoxin and Other Potential Virulence Factors of Vibrio cholerae

1989 • 15 citations