G1 events and the regulation of genes for S-phase enzymes

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

1991 • 375 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

1988 • 235 citations

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

1991 • 231 citations

Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site.

1990 • 228 citations

Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein.

1991 • 211 citations

Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor

1991 • 209 citations

G1-specific cyclins: in search of an S-phase-promoting factor

1991 • 181 citations

Control of thymidine kinase mRNA during the cell cycle.

1987 • 176 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

The MCK enhancer contains a p53 responsive element.

1991 • 170 citations

Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.

1985 • 165 citations

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo.

1989 • 144 citations

Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene.

1990 • 143 citations

Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis.

1991 • 139 citations

Gene expression of human DNA polymerase alpha during cell proliferation and the cell cycle.

1988 • 136 citations

Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate

1986 • 126 citations

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

Control of Thymidylate Synthase mRNA Content and Gene Transcription in an Overproducing Mouse Cell Line

1985 • 107 citations

Nuclear posttranscriptional processing of thymidine kinase mRNA at the onset of DNA synthesis.

1988 • 94 citations

Sequences Downstream of the Transcription Initiation Site Modulate the Activity of the Murine Dihydrofolate Reductase Promoter

1990 • 88 citations

Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene.

1990 • 87 citations

Inducible proteins binding to the murine thymidine kinase promoter in late G1/S phase.

1991 • 79 citations

Identification of a 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors.

1991 • 78 citations

Multiple protein - DNA interactions in the TATAA-less mouse thymidylate synthase promoter

1991 • 77 citations

In vitro and in vivo analysis of the control of dihydrofolate reductase gene transcription in serum‐stimulated mouse fibroblasts

1984 • 70 citations

Independent regulation of thymidine kinase mRNA and enzyme levels in serum-stimulated cells.

1990 • 64 citations

Control of thymidylate synthase mRNA content and gene transcription in an overproducing mouse cell line.

1985 • 63 citations

Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene

1991 • 59 citations

Thymidine kinase synthesis is repressed in nonreplicating muscle cells by a translational mechanism that does not affect the polysomal distribution of thymidine kinase mRNA.

1989 • 55 citations

The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.

1992 • 51 citations

Antiproliferative effects of antisense oligonucleotides directed to the RNA ofc-myconcogene

1991 • 44 citations

Human Thymidylate Synthase Gene: Isolation of Phage Clones Which Cover a Functionally Active Gene and Structural Analysis of the Region Upstream from the Translation Initiation Codon1

1989 • 43 citations

Sequences downstream of the transcription initiation site modulate the activity of the murine dihydrofolate reductase promoter.

1990 • 39 citations

Growth-responsive expression from the murine thymidine kinase promoter: genetic analysis of DNA sequences.

1991 • 34 citations

The 5'-flanking region of the mouse thymidylate synthase gene is necessary but not sufficient for normal regulation in growth-stimulated cells.

1991 • 32 citations

Temporal events regulating the early phases of the mammalian cell cycle

1991 • 31 citations

The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites.

1989 • 24 citations

Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.

1991 • 21 citations

Cell cycle-specific expression and nuclear binding of DNA polymerase alpha.

1991 • 20 citations

An intragenic region downstream from the dihydrofolate reductase promoter is required for replication-dependent expression.

1990 • 12 citations