Thermodynamic Properties of the Transition State for the Rate-Limiting Step in the Folding of the .alpha. Subunit of Tryptophan Synthase

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

1970 • 1,550 citations

The Control of Protein Stability and Association by Weak Interactions with Water: How Do Solvents Affect These Processes?

1993 • 1,076 citations

Cold Denaturation of Protein

1990 • 1,023 citations

Protein stability curves

1987 • 990 citations

[2]Scanning microcalorimetry in studying temperature-induced changes in proteins

1986 • 755 citations

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1988 • 706 citations

The Stability of Globular Protein

1975 • 648 citations

Protein interactions with urea and guanidinium chloride

1992 • 623 citations

Use of liquid hydrocarbon and amide transfer data to estimate contributions to thermodynamic functions of protein folding from the removal of nonpolar and polar surface from water

1992 • 542 citations

The Effect of Compounds of the Urea-Guanidinium Class on the Activity Coefficient of Acetyltetraglycine Ethyl Ester and Related Compounds¹

1965 • 422 citations

Heat capacity of proteins

1990 • 398 citations

Isothermal Unfolding of Globular Proteins in Aqueous Urea Solutions

1964 • 316 citations

Water as ligand: Preferential binding and exclusion of denaturants in protein unfolding

1992 • 296 citations

Solid model compounds and the thermodynamics of protein unfolding

1991 • 272 citations

Thermodynamic Problems of Protein Structure

1989 • 260 citations

Test reactions for a stopped-flow apparatus

1978 • 247 citations

Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding

1991 • 204 citations

[26] Effect of point mutations of the folding of globular proteins

1987 • 192 citations

Calorimetric determination of enthalpies of solution of slightly soluble liquids II. Enthalpy of solution of some hydrocarbons in water and their use in establishing the temperature dependence of their solubilities

1976 • 191 citations

A simple model for salvation in mixed solvents

1990 • 179 citations

A folding model of α-lactalbumin deduced from the three-state denaturation mechanism

1977 • 173 citations

Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations

1989 • 161 citations

Characterization of the transition state of Lysozyme unfolding. I. Effect of protein‐solvent interactions on the transition state

1984 • 149 citations

Mutational analysis of a protein-folding pathway

1989 • 111 citations

Urea-induced unfolding of the .alpha. subunit of tryptophan synthase: evidence for a multistate process

1981 • 109 citations

Effects of the phenylalanine-22 .fwdarw. leucine, glutamic acid-49 .fwdarw. methionine, glycine-234 .fwdarw. aspartic acid and glycine-234 .fwdarw. lysine mutations on the folding and stability of the .alpha. subunit of tryptophan synthase from Escherichia coli

1986 • 99 citations

Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor

1990 • 94 citations

[6] Protein engineering in analysis of protein folding pathways and stability

1991 • 90 citations

Role of diffusion in the folding of the .alpha. subunit of tryptophan synthase from Escherichia coli

1990 • 72 citations

Expression of functionaly of α-chymotrypsin. Effects of guanidine hydrochloride and urea in the onset of denaturation

1978 • 68 citations

Effect of single amino acid substitutions on the thermal stability of the .alpha. subunit of tryptophan synthase

1980 • 60 citations

Characterization of the slow steps in the folding of the .alpha. subunit of tryptophan synthase

1981 • 54 citations

Characterization of an early intermediate in the folding of the .alpha. subunit of tryptophan synthase by hydrogen exchange measurement

1985 • 47 citations

Characterization of a slow folding reaction for the α subunit of tryptophan synthase

1987 • 40 citations

Synergism in folding of a double mutant of the .alpha. subunit of tryptophan synthase

1986 • 38 citations

Mutagenic analysis of the interior packing of an .alpha./.beta. barrel protein. Effects on the stabilities and rates of interconversion of the native and partially folded forms of the .alpha. subunit of tryptophan synthase

1993 • 33 citations

Urea-induced unfolding of the .alpha. subunit of tryptophan synthase: One-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration

1993 • 33 citations

Multiple replacements at position 211 in the .alpha. subunit of tryptophan synthase as a probe of the folding unit association reaction

1990 • 30 citations

Strategy for trapping intermediates in the folding of ribonuclease and for using ¹H‐NMR to determine their structures

1983 • 27 citations

Proline isomerization and the slow folding reactions of the α subunit of tryptophan synthase from Escherichia coli

1987 • 25 citations

[7] Mutatational analysis of protein folding mechanisms

1991 • 24 citations

Thermal stabilities of mutant Escherichia coli tryptophan synthase α subunits

1992 • 15 citations

Amino acid replacements can selectively affect the interaction energy of autonomous folding units in the .alpha. subunit of tryptophan synthase

1992 • 13 citations