Strategy for trapping intermediates in the folding of ribonuclease and for using ¹H‐NMR to determine their structures

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Theory of helix-coil transitions in biopolymers

1970 • 734 citations

Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance

1982 • 568 citations

Sequential resonance assignments in protein 1H nuclear magnetic resonance spectra

1982 • 562 citations

Experimental studies of protein folding and unfolding

1979 • 535 citations

Hydrogen Exchange

1972 • 423 citations

Hydrogen Bonds between Model Peptide Groups in Solution

1962 • 370 citations

Amide proton exchange and surface conformation of the basic pancreatic trypsin inhibitor in solution

1982 • 332 citations

Helix-coil transition of the isolated amino terminus of ribonuclease

1971 • 310 citations

A salt bridge stabilizes the helix formed by isolated C-peptide of RNase A.

1982 • 284 citations

Acid catalysis of the formation of the slow-folding species of RNase A: Evidence that the reaction is proline isomerization

1978 • 229 citations

Protein dynamics investigated by the neutron diffraction–hydrogen exchange technique

1982 • 180 citations

Role of proline isomerization in folding of ribonuclease A at low temperatures

1979 • 161 citations

Both the Fast and Slow Refolding Reactions of Ribonuclease A Yield Native Enzyme

1973 • 157 citations

Detection of an early intermediate in the folding of ribonuclease A by protection of amide protons against exchange

1979 • 154 citations

Test of the extended two-state model for the kinetic intermediates observed in the folding transition of ribonuclease A

1978 • 137 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 118 citations

Use of random copolymers to determine the helix-coil stability constants of the naturally occurring amino acids

1978 • 99 citations

Individual breathing reactions measured in hemoglobin by hydrogen exchange methods

1980 • 92 citations

Structural intermediates trapped during the folding of ribonuclease A by amide proton exchange

1980 • 86 citations

Concentration-dependent hydrogen exchange kinetics of 3H-labeled S-peptide in ribonuclease S

1976 • 74 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

A Native‐Like Intermediate on the Ribonuclease A Folding Pathway

1981 • 69 citations

Hydrogen exchange in RNase A: neutron diffraction study.

1982 • 68 citations

Regeneration of ribonuclease A from the reduced protein. Isolation and identification of intermediates and equilibrium treatment

1981 • 66 citations

Near Infrared Investigation of Interamide Hydrogen Bonding in Aqueous Solution

1964 • 52 citations

Effects of solvent viscosity and different guanidine salts on the kinetics of ribonuclease A chain folding

1978 • 52 citations

Direct observation of peptide exchange by stable isotope enrichment.

1980 • 12 citations