Urea-induced unfolding of the .alpha. subunit of tryptophan synthase: One-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Nucleation, Rapid Folding, and Globular Intrachain Regions in Proteins

1973 • 826 citations

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1988 • 706 citations

The Solubility of Amino Acids and Related Compounds in Aqueous Urea Solutions

1963 • 657 citations

Protein folding: Hypotheses and experiments

1987 • 544 citations

Defining Solution Conformations of Small Linear Peptides

1991 • 528 citations

Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding

1988 • 463 citations

NMR Determination of Residual Structure in a Urea-Denatured Protein, the 434-Repressor

1992 • 449 citations

MUTATIONAL EFFECTS ON PROTEIN STABILITY

1989 • 311 citations

Prolyl Isomerase: Enzymatic Catalysis of Slow Protein-Folding Reactions

1993 • 307 citations

A Method for Predicting Nucleation Sites for Protein Folding Based on Hydrophobic Contacts

1978 • 189 citations

The influence of long-range interactions on the structure of myoglobin

1968 • 169 citations

The Tryptophan Synthase from Escherichia coli

1975 • 131 citations

Isolation and characterization of independently folding regions of the β chain of Escherichia coli tryptophan synthetase

1977 • 121 citations

Solubility of different folding conformers of bovine growth hormone

1988 • 114 citations

[49] Tryptophan synthase from Escherichia coli and Salmonella typhimurium

1987 • 110 citations

Urea-induced unfolding of the .alpha. subunit of tryptophan synthase: evidence for a multistate process

1981 • 109 citations

Effects of the phenylalanine-22 .fwdarw. leucine, glutamic acid-49 .fwdarw. methionine, glycine-234 .fwdarw. aspartic acid and glycine-234 .fwdarw. lysine mutations on the folding and stability of the .alpha. subunit of tryptophan synthase from Escherichia coli

1986 • 99 citations

Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor

1990 • 94 citations

Guanidine hydrochloride-induced unfolding of the .alpha. subunit of tryptophan synthase and of the two .alpha. proteolytic fragments: evidence for stepwise unfolding of the two .alpha. domains

1982 • 88 citations

Characterization of an associated equilibrium folding intermediate of bovine growth hormone

1986 • 81 citations

The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration

1979 • 71 citations

Hypothesis about the Mechanism of Protein Folding

1977 • 67 citations

Stabilization of an associated folding intermediate of bovine growth hormone by site-directed mutagenesis.

1988 • 64 citations

Effect of a single amino acid substitution on the folding of the .alpha. subunit of tryptophan synthase

1983 • 61 citations

Complete ¹⁵ N and ¹ H NMR assignments for the amino-terminal domain of the phage 434 repressor in the urea-unfolded form

1992 • 60 citations

Preparation and characterization of a modified form of beta2 subunit of Escherichia coli tryptophan synthetase suitable for investigating protein folding.

1977 • 57 citations

Characterization of the slow steps in the folding of the .alpha. subunit of tryptophan synthase

1981 • 54 citations

Comparison of Denaturation by Guanidine Hydrochloride of the Wild Type Tryptophan Synthase α-Subunit of Escherichia coli and Two Mutant Proteins (Glu 49—Met or Gln)

1979 • 53 citations

Characterization of an early intermediate in the folding of the .alpha. subunit of tryptophan synthase by hydrogen exchange measurement

1985 • 47 citations

pH dependence of stability of the wild-type tryptophan synthase α-subunit and two mutant proteins (Glu49 → Met or Gln)

1980 • 45 citations

Characterization of a slow folding reaction for the α subunit of tryptophan synthase

1987 • 40 citations

Helical formation in isolated fragments of bovine growth hormone

1987 • 34 citations

Mutagenic analysis of the interior packing of an .alpha./.beta. barrel protein. Effects on the stabilities and rates of interconversion of the native and partially folded forms of the .alpha. subunit of tryptophan synthase

1993 • 33 citations

Multiple replacements at position 211 in the .alpha. subunit of tryptophan synthase as a probe of the folding unit association reaction

1990 • 30 citations

Nuclear magnetic resonance titration curves of histidine ring protons. The effect of temperature on ribonuclease A.

1975 • 24 citations

Tests of the simple model of Lin and Brandts for the folding kinetics of ribonuclease A

1984 • 20 citations

Proton nuclear magnetic resonance studies on the wild-type and single amino acid substituted tryptophan synthase .alpha.-subunits

1987 • 14 citations

NMR evidence for the stepwise unfolding of the two domains of tryptophan synthase α-subunit

1983 • 11 citations