INTERFERON α AUGMENTS ACTIVATION-INDUCED T CELL DEATH BY UPREGULATION OF FAS (CD95/APO-1) AND FAS LIGAND EXPRESSION

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Apoptosis

1993 • 972 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Fas ligand in human serum

1996 • 682 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

The CTL's kiss of death

1995 • 504 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

A survey of adverse events in 11 241 patients with chronic viral hepatitis treated with alfa interferon

1996 • 498 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

1995 • 398 citations

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

1994 • 363 citations

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

1993 • 314 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

The role of FasL-induced apoptosis in immune privilege

1997 • 262 citations

Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages

1997 • 243 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

New insights into the mechanisms of interferon alfa: An immunoregulatory and anti-inflammatory cytokine

1997 • 212 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

1997 • 152 citations

Contribution of Fas ligand to T cell-mediated hepatic injury in mice

1997 • 139 citations

Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis

1998 • 108 citations

Acute hematologic effects of interferon alpha, interferon gamma, tumor necrosis factor alpha and Interleukin 2

1991 • 44 citations

DIFFERENTIAL REGULATION OF INTERLEUKIN 4 AND INTERLEUKIN 13 PRODUCITON BY INTERFERON α

1998 • 40 citations

The Effects of Long-Term Administration of Recombinant Alpha-2 Interferon on Lymphocyte Subsets, Proliferation, and Suppressor Cell Function in Multiple Sclerosis

1986 • 19 citations

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