Calcineurin Inhibitor–Induced Nephrotoxicity and Renal Expression of P-glycoprotein

Prediction of Creatinine Clearance from Serum Creatinine

1976 • 15,066 citations

The Natural History of Chronic Allograft Nephropathy

2003 • 1,899 citations

Caspases: the proteases of the apoptotic pathway

1998 • 1,048 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy

1996 • 443 citations

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

1998 • 357 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death

1999 • 308 citations

Up-regulation of Multidrug Resistance P-glycoprotein via Nuclear Factor-κB Activation Protects Kidney Proximal Tubule Cells from Cadmium- and Reactive Oxygen Species-induced Apoptosis

2000 • 305 citations

Multiple physiological functions for multidrug transporter P-glycoprotein?

2000 • 305 citations

LONG-TERM SURVIVAL AND RENAL FUNCTION FOLLOWING LIVER TRANSPLANTATION IN PATIENTS WITH AND WITHOUT HEPATORENAL SYNDROME

1991 • 305 citations

Cyclosporine nephrotoxicity

2003 • 244 citations

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes

1996 • 225 citations

Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis

1998 • 170 citations

Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts

1997 • 149 citations

Expression and function of P-glycoprotein in a mouse kidney cell line

1995 • 123 citations

Expression of MDR1 (Multidrug Resistance) Gene and Its Protein in Normal Human Kidney

1997 • 108 citations

Time Course of the Decline in Renal Function in Cyclosporine-Treated Heart Transplant Recipients

1994 • 102 citations

Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients

2001 • 92 citations

Potentiation by Nitric Oxide of Cyclosporin A and FK506-Induced Apoptosis in Renal Proximal Tubule Cells

2000 • 86 citations

Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications.

2001 • 83 citations

Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure

2000 • 80 citations

Cyclosporine A induces apoptosis in murine tubular epithelial cells: Role of caspases

1998 • 79 citations

Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells

2000 • 69 citations

Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells

1998 • 68 citations

Cyclosporine nephrotoxicity: how does it affect renal allograft function and transplant morphology?

2004 • 68 citations

Caspase-Mediated Calcineurin Activation Contributes to IL-2 Release during T Cell Activation

2001 • 53 citations

P Glycoprotein: A New Mechanism to Control Drug-Induced Nephrotoxicity

1998 • 48 citations

MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling.

2002 • 46 citations

P-Glycoprotein-Mediated Drug Secretion in Mouse Proximal Tubule Perfused In Vitro

2001 • 41 citations

Relationship between P-glycoprotein expression and cyclosporin A in kidney. An immunohistological and cell culture study.

1995 • 41 citations

Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits.

1997 • 39 citations

Expression and function of P-glycoprotein in human mesangial cells

1994 • 25 citations

Mapping Pathological <sup>99m</sup>Tc-<i>d,l</i>-Hexamethylpropylene Amine Oxime Uptake in Alzheimer’s Disease and Frontal Lobe Dementia with SPECT

2001 • 25 citations

Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal.

2004 • 24 citations

Role of p-glycoprotein in chronic cyclosporine nephrotoxicity and its relationship to intrarenal angiotensin ii deposits

1998 • 19 citations

Kidney biopsy findings in cyclosporine-treated patients with insulin-dependent diabetes mellitus

1991 • 16 citations