Relationship between P-glycoprotein expression and cyclosporin A in kidney. An immunohistological and cell culture study.

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology

1993 • 1,431 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

1989 • 580 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

1993 • 366 citations

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 357 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Histopathological findings in well-functioning, long-term renal allografts

1992 • 243 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

Multidrug resistance (mdr) genes in human cancer

1991 • 209 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

Histopathology of cyclosporine nephrotoxicity.

1988 • 182 citations

Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.

1992 • 156 citations

Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation.

1985 • 144 citations

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

1993 • 125 citations

Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.

1988 • 121 citations

Immunohistochemical detection of the multidrug transport protein P1 70 in human normal tissues and malignant lymphomas

1991 • 104 citations

Cyclosporin A nephropathy: standardization of the evaluation of kidney biopsies.

1994 • 101 citations

P‐glycoprotein‐mediated transcellular transport of MDR‐reversing agents

1993 • 92 citations

The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi‐drug transporter

1993 • 91 citations

Phase I pharmacokinetic study of cyclosporin A combined with doxorubicin.

1993 • 91 citations

RENAL TRANSPLANT FUNCTION AFTER TEN YEARS OF CYCLOSPORINE

1992 • 81 citations

Structure-Based Design of a Cyclophilin-Calcineurin Bridging Ligand

1993 • 78 citations

Levels of expression of the mdr1 gene and glutathione S-transferase genes 2 and 3 and response to chemotherapy in multiple myeloma

1992 • 63 citations

Pharmacokinetics of cyclosporine: inter- and intra-individual variations and metabolic pathways.

1990 • 61 citations

Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Monoclonal Antibodies, Immunotoxins or Antisense Oligodeoxynucleotides in Kidney Carcinoma and Normal Kidney Cells

1993 • 47 citations

Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: A role for cysteine proteases

1991 • 36 citations

Multidrug resistance in lung allograft recipients: possible correlation with the development of acute and chronic rejection.

1993 • 34 citations

Multidrug resistance in heart transplant patients: a preliminary communication on a possible mechanism of therapy-resistant rejection.

1991 • 31 citations

Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro

1992 • 27 citations

IN VITRO CYCLOSPORINE TOXICITY

1989 • 25 citations

Reliability of anin vitro short-term assay to predict the drug sensitivity of human breast cancer

1985 • 22 citations

Identification of the Multidrug Resistance-Related Membrane Glycoprotein as an Acceptor for Cyclosporine

1991 • 21 citations

Structural elements pertinent to the interaction of cyclosporin a with its specific receptor protein, cyclophilin

1990 • 15 citations

Measurement of proliferation nuclear and membrane markers in tumor cells by flow cytometry.

1991 • 14 citations

Interaction of P-glycoprotein with a hydrophobic component of rat urine

1992 • 13 citations

Optimization of cyclosporine therapy.

1993 • 13 citations

Derivation and characterisation of a mouse tumour cell line with acquired resistance to cyclosporin A

1993 • 5 citations

Optimization and long-term evaluation of renal function in sandimmune-treated renal allograft recipients.

1993 • 1 citations