Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Regulated internalization of caveolae.

1994 • 760 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

Dynamic Targeting of the Agonist-stimulated m2 Muscarinic Acetylcholine Receptor to Caveolae in Cardiac Myocytes

1997 • 275 citations

Dual pathways of internalization of the cholecystokinin receptor.

1995 • 236 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

1994 • 182 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases

1996 • 170 citations

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms

1995 • 155 citations

Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.

1994 • 150 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

Two Homologous Phosphorylation Domains Differentially Contribute to Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor

1997 • 116 citations

Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.

1993 • 109 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.

1994 • 109 citations

G Protein‐Coupled Receptor Kinases

1994 • 104 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor

1993 • 96 citations

Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β₂-Adrenergic Receptor Facilitate Sequestration

1996 • 88 citations

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.

1994 • 85 citations

Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.

1985 • 85 citations

Human Muscarinic Cholinergic Receptor Hm1 Internalizes via Clathrin-coated Vesicles

1996 • 80 citations

G Protein-coupled Receptor Kinase Specificity for Phosphorylation and Desensitization of α2-Adrenergic Receptor Subtypes

1996 • 78 citations

Involvement of G Protein-coupled Receptor Kinase 5 in Homologous Desensitization of the Thyrotropin Receptor

1996 • 65 citations

Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)

1994 • 61 citations

Activation of a GTP‐Binding Protein and a GTP‐Binding‐Protein‐Coupled Receptor Kinase (β‐Adrenergic‐Receptor Kinase‐1) by a Muscarinic Receptor m2 Mutant Lacking Phosphorylation Sites

1994 • 41 citations

Muscarinic Receptor Sequestration in SH‐SY5Y Neuroblastoma Cells Is Inhibited when Clathrin Distribution Is Perturbed

1996 • 38 citations